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  • ️Parkes, Miles

Article (Scientific journals)

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

; McGovern, Dermot P B; Barrett, Jeffrey C et al.

2010In Nature Genetics, 42 (12), p. 1118-25

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Keywords :

Computational Biology; Crohn Disease/etiology/genetics; Genetic Linkage; Genetic Loci/genetics; Genetic Predisposition to Disease; Genetic Variation; Genome, Human/genetics; Genome-Wide Association Study; Humans; Reproducibility of Results

Abstract :

[en] We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

Disciplines :

Genetics & genetic processes
Gastroenterology & hepatology

Author, co-author :

Franke, Andre

McGovern, Dermot P B

Barrett, Jeffrey C

Wang, Kai

Radford-Smith, Graham L

Ahmad, Tariq

Lees, Charlie W

Balschun, Tobias

Lee, James

Roberts, Rebecca

Anderson, Carl A

Bis, Joshua C

Bumpstead, Suzanne

Ellinghaus, David

Festen, Eleonora M

Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Green, Todd

Haritunians, Talin

Jostins, Luke

Latiano, Anna

Mathew, Christopher G

Montgomery, Grant W

Prescott, Natalie J

Raychaudhuri, Soumya

Rotter, Jerome I

Schumm, Philip

Sharma, Yashoda

Simms, Lisa A

Taylor, Kent D

Whiteman, David

Wijmenga, Cisca

Baldassano, Robert N

Barclay, Murray

Bayless, Theodore M

Brand, Stephan

Buning, Carsten

Cohen, Albert

Colombel, Jean*-Frederick

Cottone, Mario

Stronati, Laura

Denson, Ted

Devos, Martine ;  Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie

D'Inca, Renata

Dubinsky, Marla

Edwards, Cathryn

Florin, Tim

Franchimont, Denis

Gearry, Richard

Glas, Jurgen

Van Gossum, Andre

Guthery, Stephen L

Halfvarson, Jonas

Verspaget, Hein W

Hugot, Jean*-Pierre

Karban, Amir

Laukens, Debby

Lawrance, Ian

Lemann, Marc

Levine, Arie

Libioulle, Cécile  ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique

Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie

Mowat, Craig

Newman, William

Panes, Julian

Phillips, Anne

Proctor, Deborah D

Regueiro, Miguel

Russell, Richard

Rutgeerts, Paul

Sanderson, Jeremy

Sans, Miquel

Seibold, Frank

Steinhart, A Hillary

Stokkers, Pieter C F

Torkvist, Leif

Kullak-Ublick, Gerd

Wilson, David

Walters, Thomas

Targan, Stephan R

Brant, Steven R

Rioux, John D

D'Amato, Mauro

Weersma, Rinse K

Kugathasan, Subra

Griffiths, Anne M

Mansfield, John C

Vermeire, Severine

Duerr, Richard H

Silverberg, Mark S

Satsangi, Jack

Schreiber, Stefan

Cho, Judy H

Annese, Vito

Hakonarson, Hakon

Daly, Mark J

Parkes, Miles

Title :

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Journal title :

Nature Genetics

Publisher :

Nature Publishing Group, New York, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 February 2011

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Scopus citations®
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1776


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