Kyoto University Research Information Repository: Triboelectrification of pharmaceutical powders by particle impact.
- ️Masuda, Hiroaki
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http://hdl.handle.net/2433/194296
| タイトル: | Triboelectrification of pharmaceutical powders by particle impact. |
| 著者: | Watanabe, Hideo Ghadiri, Mojtaba Matsuyama, Tatsushi Ding, Yu Long Pitt, Kendal G Maruyama, Hiroyuki    https://orcid.org/0000-0003-0017-5380 (unconfirmed)Matsusaka, Shuji https://orcid.org/0000-0001-9048-929X (unconfirmed)Masuda, Hiroaki |
| 著者名の別形: | 松坂, 修二 |
| キーワード: | Triboelectrification Charge transfer Particle impact Equilibrium charge Triboelectric series Contact potential difference |
| 発行日: | 4-Apr-2007 |
| 出版者: | Elsevier B.V. |
| 誌名: | International journal of pharmaceutics |
| 巻: | 334 |
| 号: | 1-2 |
| 開始ページ: | 149 |
| 終了ページ: | 155 |
| 抄録: | Pharmaceutical powders are very prone to electrostatic charging by colliding and sliding contacts with walls and other particles. In pharmaceutical formulation processes, particle charging is often a nuisance and can cause problems in the manufacture of products, such as affecting powder flow, and reducing fill and dose uniformity. For a fundamental understanding of the powder triboelectrification, it is essential to study charge transfer due to a single contact of a particle with a target plane under well-defined physical, mechanical and electrical conditions. In this study, charge transfer due to a single impact of a particle against a stainless steel target was measured for alpha-lactose monohydrate, aspirin, sugar granules and ethylcellulose. The amount of transferred charge is expressed as a function of impact velocity and impact angle as well as the initial charge. The maximum contact area during impact between a particle and a target plane is estimated by an elastic-plastic deformation model. It is found that the transferred charge is a linear function of the contact area. For a given material, there is an initial particle charge for which no charge transfer occurs due to impact. This is found to be independent of impact velocity and angle, and is hence viewed as a characteristic property, which is related to the contact potential difference and tribo-electric series of the sample powders. |
| 著作権等: | © 2006 Elsevier B.V. NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 334(1-2) 149-156, 2004, doi:10.1016/j.ijpharm.2006.11.005 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/194296 |
| DOI(出版社版): | 10.1016/j.ijpharm.2006.11.005 |
| PubMed ID: | 17141989 |
| 関連リンク: | http://hdl.handle.net/2433/67041 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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