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Dipòsit Digital de la Universitat de Barcelona: Long-term clinical and functional course of Borderline Personality Disorder: A meta-analysis of prospective studies

️Bados López, Arturo
️Tue Apr 06 2021

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/175985

Title:	Long-term clinical and functional course of Borderline Personality Disorder: A meta-analysis of prospective studies
Author:	Ruiz Rodríguez, José Guilera Ferré, Georgina Bados López, Arturo
Keywords:	Trastorns límits de la personalitat Metaanàlisi Borderline personality disorder Meta-analysis
Issue Date:	Feb-2019
Publisher:	Cambridge University Press
Abstract:	Background: This meta-analytic review is the first to synthesize findings from prospective research on the long-term course of borderline personality disorder in adult clinical populations. Methods: Systematic searches were conducted in Medline, PsycINFO, PsycArticles, PubMed, and Scopus within the period 1990-2017. Inclusion criteria were: (1) adult BPD sample diagnosed by a validated, semi-structured interview; (2) at least two prospective assessments of outcomes; and (3) follow-up period ≥ 5 years. Quality of evidence was rated with the Systematic Assessment of Quality in Observational Research (SAQOR). Four outcomes were meta-analysed using mixed-effect methods: remission from BPD diagnosis, completed suicide, depressive symptoms, and functioning. Potential moderators regarding the natural course and the initial treatment received were studied. Results: Eleven studies met the inclusion criteria, with 837 participants from nine countries being followed. Between 50% and 70% of the BPD patients achieved remission in the long-term. Significant reductions in depression and functional impairment were also found. Mean suicide rate ranged from 2% to 5%. Younger age was associated with a higher likelihood of remission. Being female was correlated with lower functional improvement. Despite some positive trends, there were no significant associations between treatment moderators and the long-term outcome. Conclusions: Findings suggest that the course of BPD is characterized by symptomatic amelioration and a slight functional improvement in the long-term. Age and gender modulate the long-term prognosis and should be considered to adapt treatment resources. Further research is required to draw robust conclusions on the long-term effects of psychotherapeutic interventions.
Note:	Reproducció del document publicat a: https://doi.org/10.1016/j.eurpsy.2018.10.010
It is part of:	European Psychiatry, 2019, vol. 56, num. 1, p. 75-83
URI:	https://hdl.handle.net/2445/175985
Related resource:	https://doi.org/10.1016/j.eurpsy.2018.10.010
ISSN:	0924-9338
Appears in Collections:	Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) Articles publicats en revistes (Psicologia Clínica i Psicobiologia)