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Journal of Nanobiotechnology

  • Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon

    The absence of signaling pathways related to intrinsic immune activation in tumor cells and the immunosuppressive microenvironment limit lymphocyte infiltration, constitutes an “immune-desert” tumor displaying...

    Authors: Man Li, Lisen Lu, Qiuhong Bao, Minghui Zhou, Bin Nie, Yanchao Liu, Kai Shu, Ting Lei and Mingxin Zhu

    Citation: Journal of Nanobiotechnology 2025 23:239

    Content type: Research Published on: 22 March 2025

  • DNAzyme hydrogels specifically inhibit the NLRP3 pathway to prevent radiation-induced skin injury in mice

    Radiation-induced skin injury (RISI) is a frequent complication of radiotherapy, yet current preventive strategies exhibit suboptimal efficacy. Our previous publications have consistently demonstrated the effe...

    Authors: Daijun Zhou, Zhihui Li, Linbo Bao, Xiang Zhao, Jie Hao, Chuan Xu, Feifan Sun, Dan He, Chaoyang Jiang, Tian Zeng and Dong Li

    Citation: Journal of Nanobiotechnology 2025 23:238

    Content type: Research Published on: 22 March 2025

  • Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis

    Atherosclerosis serving as the main underlying factor of cardiovascular disease (CVD) remains the primary cause of mortality and morbidity globally, while the deposition of massive cholesterol in macrophage-de...

    Authors: Yang Li, Xiaoxia Xue, Liuchunyang Yu, Jinxiu Qian, Xiaoyu Li, Meng Tian, Jue Yang, Rongjun Deng, Cheng Lu, Cheng Xiao and Yuanyan Liu

    Citation: Journal of Nanobiotechnology 2025 23:237

    Content type: Research Published on: 22 March 2025

  • Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer

    Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as a promising strategy for the treatment of TN...

    Authors: Fen Liu, Qiang Kang, Hao Xiao, Yinying Liu, Sengyou Tan, Kun Fan, Jianchun Peng, Xiaofeng Tan, Guilong Wu and Qinglai Yang

    Citation: Journal of Nanobiotechnology 2025 23:235

    Content type: Research Published on: 22 March 2025

  • Microalgae-based biodegradable embolic agent for the treatment of hepatocellular carcinoma through transarterial embolization

    Transarterial chemoembolization (TACE) serves as a locoregional therapy for hepatocellular carcinoma (HCC) patients. Nevertheless, the rapid dissociation of conventional TACE (cTACE) preparations, attributed t...

    Authors: Kaiyue Wang, Danni Zhong, Lingxiao Yang, Cheng Zeng, Qitao Hu, Min Zhou and Zhe Tang

    Citation: Journal of Nanobiotechnology 2025 23:234

    Content type: Research Published on: 22 March 2025

  • Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications

    Physical stimuli-responsive DNA hydrogels hold immense potential for tissue engineering due to their inherent biocompatibility, tunable properties, and capacity to replicate the mechanical environment of natur...

    Authors: Rumi Acharya, Sayan Deb Dutta, Hemadri Mallik, Tejal V. Patil, Keya Ganguly, Aayushi Randhawa, Hojin Kim, Jieun Lee, Hyeonseo Park, Changyeun Mo and Ki-Taek Lim

    Citation: Journal of Nanobiotechnology 2025 23:233

    Content type: Review Published on: 22 March 2025

  • Revolutionizing lung cancer treatment: harnessing exosomes as early diagnostic biomarkers, therapeutics and nano-delivery platforms

    Lung cancer, known for its high morbidity and mortality rates, remains one of the most critical health challenges globally. Conventional treatment options, such as chemotherapy and surgery, are often limited b...

    Authors: Qiyao Xiao, Minhong Tan, Ge Yan and Lihua Peng

    Citation: Journal of Nanobiotechnology 2025 23:232

    Content type: Review Published on: 21 March 2025

  • Micro/Nanoplastics in plantation agricultural products: behavior process, phytotoxicity under biotic and abiotic stresses, and controlling strategies

    With the extensive utilization of plastic products, microplastics/nanoplastics (MPs/NPs) contamination not only poses a global hazard to the environment, but also induces a new threat to the growth development...

    Authors: Zhihao Lin, Donghui Xu, Yiming Zhao, Bin Sheng, Zhijian Wu, Xiaobin Wen, Jie Zhou, Ge Chen, Jun Lv, Jing Wang and Guangyang Liu

    Citation: Journal of Nanobiotechnology 2025 23:231

    Content type: Review Published on: 21 March 2025

  • Small extracellular vesicles: crucial mediators for prostate cancer

    Small extracellular vesicles (sEVs) play a critical role in the progression, diagnosis, and treatment of prostate cancer (PCa), particularly within the tumor microenvironment (TME). Acting as novel biomarkers ...

    Authors: Sijie Tang, Huiying Cheng, Xueyan Zang, Jiawei Tian, Zhongli Ling, Lingling Wang, Wenrong Xu and Jiajia Jiang

    Citation: Journal of Nanobiotechnology 2025 23:230

    Content type: Review Published on: 21 March 2025

  • Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury

    Traumatic brain injury (TBI) is a leading cause of disability in adults, significantly affecting patients’ quality of life. Extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cell...

    Authors: Pengtao Li, Sishuai Sun, Xingyu Zhu, Xiaoyu Liu, Rui Yin, Yihao Chen, Jianbo Chang, Liguo Ye, Jingxi Gao, Xiaoyan Zhao, Houshi Xu, Yue Wang, Wei Zuo, Zhao Sun, Shihua Wang, Xiao Zhang…

    Citation: Journal of Nanobiotechnology 2025 23:229

    Content type: Research Published on: 21 March 2025

  • miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren’s syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis

    Sjögren’s syndrome (SS) is an autoimmune disease primarily affecting salivary glands, with xerostomia as a distinct clinical manifestation. This disease also poses a significantly increased risk of lymphoma, s...

    Authors: Yufei Xie, Maosheng Chai, Yixiao Xing, Peiru Zhou, Pan Wei and Hong Hua

    Citation: Journal of Nanobiotechnology 2025 23:228

    Content type: Research Published on: 20 March 2025

  • Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release

    Inflammatory bowel disease (IBD) is characterized by compromised intestinal barrier function and a lack of effective treatments. Probiotics have shown promise in managing IBD due to their ability to modulate t...

    Authors: Yuanyuan Wu, Xinyue Huang, Qianbei Li, Chaoqun Yang, Xixin Huang, Hualongyue Du, Bo Situ, Lei Zheng and Zihao Ou

    Citation: Journal of Nanobiotechnology 2025 23:227

    Content type: Research Published on: 20 March 2025

  • Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs

    Sepsis-induced acute lung injury (ALI) remains a critical clinical challenge with complex inflammatory pathogenesis. While bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential through a...

    Authors: Wan-Jie Gu, Feng-Zhi Zhao, Wei Huang, Ming-Gao Zhu, Hai-Yan Huang, Hai-Yan Yin and Tianfeng Chen

    Citation: Journal of Nanobiotechnology 2025 23:226

    Content type: Research Published on: 20 March 2025

  • ZnO-Cu/Mn nanozyme for rescuing the intestinal homeostasis in Salmonella-induced colitis

    Salmonella is one of the most common foodborne pathogens, which can cause severe enteritis and intestinal microbiota imbalance. However, there are limited strategies currently available for preventing or treating...

    Authors: Aimin Wu, Chen Liang, WenShuang Chen, ChangFang Lu, JunZhou Chen, Bing Wu, Daiwen Chen, Li He and Xianxiang Wang

    Citation: Journal of Nanobiotechnology 2025 23:225

    Content type: Research Published on: 20 March 2025

  • Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy

    Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secr...

    Authors: Xuan Sha, Chuanbing Wang, Yang Liu, Nan Zhong, Yishi Lu, Qi Zhang, Shangyu Lu, Doudou He, Yingying Jin, Yuxia Tang and Shouju Wang

    Citation: Journal of Nanobiotechnology 2025 23:224

    Content type: Research Published on: 19 March 2025

  • Influence of salt solution on the physicochemical properties and in vitro/ in vivo expression of mRNA/LNP

    Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabling significant advances in mRNA-based therapeutics. While extensive research has focused on lipid composition, the impact of preparat...

    Authors: Siyuan Tang, Lei Huang, Jiahao Ge, Jie Li, Mingxia Qiu, Yiqing Zhang, Mei Long, Gang Wu, Rui Zhang, Xueyun Ma, Qiang Xia, Ping Wan and Taihua Yang

    Citation: Journal of Nanobiotechnology 2025 23:223

    Content type: Research Published on: 19 March 2025

  • Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells

    Liver fibrosis is a leading cause of liver-related mortality worldwide, yet effective therapies remain limited. Mesenchymal stem cells (MSCs) have recently shown promise in treating liver fibrosis due to their...

    Authors: Zheng Wang, Mengqin Yuan, Lichao Yao, Zhiyu Xiong, Kai Dai, Pingji Liu, Ping Chen, Muhua Sun, Kan Shu, Yuchen Xia and Yingan Jiang

    Citation: Journal of Nanobiotechnology 2025 23:222

    Content type: Research Published on: 19 March 2025

  • The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens

    Lipid nanoparticles (LNP) are a safe and effective messenger RNA (mRNA) delivery system for vaccine applications, as shown by the COVID-19 mRNA vaccines. One of the main challenges faced during the development...

    Authors: Renata S. Fernandes, Gabriela de Assis Burle-Caldas, Sarah Aparecida Rodrigues Sergio, Ana Flávia Bráz, Nathália Pereira da Silva Leite, Milton Pereira, Juliana de Oliveira Silva, Natália Satchiko Hojo-Souza, Bianca de Oliveira, Ana Paula S. Moura Fernandes, Flávio Guimarães da Fonseca, Ricardo Tostes Gazzinelli, Diego dos Santos Ferreira and Santuza M. Ribeiro Teixeira

    Citation: Journal of Nanobiotechnology 2025 23:221

    Content type: Research Published on: 18 March 2025

  • Biomimetic gold nano-modulator for deep-tumor NIR-II photothermal immunotherapy via gaseous microenvironment remodeling strategy

    Effective immunotherapeutic treatment of solid tumors has been greatly challenged by the complex hostile tumor immunosuppressive microenvironment (TIME), which typically involves hypoxia and immunosuppression.

    Authors: Honglin Huang, Zhengxin Xie, Ningxi Li, Li Zeng, Qianyi Zeng, Ziman Yang, Jinyang Shen, Hong Yang, Yiyao Liu and Chunhui Wu

    Citation: Journal of Nanobiotechnology 2025 23:220

    Content type: Research Published on: 18 March 2025

  • Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine

    Stem cell-derived extracellular vesicles (EVs) have emerged as a safe and potent alternative to regenerative medicine in recent decades. Furthermore, the adjustment of EV functions has been recently enabled by...

    Authors: Donghyeon Yoo, Se Young Jung, Dabin Go, Ji Yeong Park, Dong Gil You, Won-Kyo Jung, Yuce Li, Jianxun Ding, Jae Hyung Park and Wooram Um

    Citation: Journal of Nanobiotechnology 2025 23:219

    Content type: Review Published on: 18 March 2025

  • A multiple-crosslinked injectable hydrogel for modulating tissue microenvironment and accelerating infected diabetic wound repair

    Elevated oxidative stress and inflammation, bacterial infections, and vascular impairment undoubtedly impede the normal diabetic wound healing process, which has encouraged the development of high-performance ...

    Authors: Zhengduo Zhang, Yuanyuan Ding, Huipu Yuan, Chen Rui, Pengfei Fan, Yinwen Ji, Ying Xiao, Jiayong Dai and Lei Li

    Citation: Journal of Nanobiotechnology 2025 23:218

    Content type: Research Published on: 18 March 2025

  • Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy

    Non-small cell lung cancer (NSCLC) represents the most prevalent form of lung cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is the standard treatment for NSCLC, but resis...

    Authors: Man Fang, Lei Cao, Zhao Zhang, Zhen Yu, Yue Shen, Jieqi Chen, Juan Chen, Yue-Qin Li, Zhaoqian Liu, Yingcai Meng, Haihua Xiao, Qiang Qu, Ji-Ye Yin and Xiang-Ping Li

    Citation: Journal of Nanobiotechnology 2025 23:217

    Content type: Research Published on: 18 March 2025

  • Functions and application of circRNAs in vascular aging and aging-related vascular diseases

    Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding RNAs generated through the reverse splicing of mRNA precursors, possess the capacity to regulate gene transcription and translation...

    Authors: Sha-Qi He, Bei Huang, Feng Xu, Jun-Jie Yang, Cong Li, Feng-Rong Liu, Ling-Qing Yuan, Xiao Lin and Jun Liu

    Citation: Journal of Nanobiotechnology 2025 23:216

    Content type: Review Published on: 17 March 2025

  • Protective effects of bone marrow mesenchymal stem cell-derived exosomes loaded cerium dioxide nanoparticle against deoxynivalenol-induced liver damage

    Deoxynivalenol (DON), a mycotoxin produced by Fusarium species, posed significant threats to food safety and human health due to its widespread prevalence and detrimental effects. Upon exposure, the liver, whi...

    Authors: Zitong Meng, Mingmeng Tang, Shiyin Xu, Xiaolei Zhou, Zixuan Zhang, Liunan Yang, Andreas K. Nüssler, Liegang Liu and Wei Yang

    Citation: Journal of Nanobiotechnology 2025 23:215

    Content type: Research Published on: 17 March 2025

  • Stem cells derived exosome laden oxygen generating hydrogel composites with good electrical conductivity for the tissue-repairing process of post-myocardial infarction

    Acute myocardial infarction (AMI) destroys heart cells by disrupting the oxygen supply. Improving oxygen delivery to the injured area may avoid cell death and regenerate the heart. We present the creation of o...

    Authors: Zhaoyan Xu, Wanzi Hong, Yuanxi Mo, Fen Shu, Yaoxin Liu, Yuqi Cheng, Ning Tan and Lei Jiang

    Citation: Journal of Nanobiotechnology 2025 23:213

    Content type: Research Published on: 17 March 2025

  • Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation

    Elevated copper levels induce tumor cuproptosis and ferroptosis, leading to immunogenic cell death and subsequent antitumor immune responses. However, dysregulated copper metabolism in tumor cells maintains ho...

    Authors: Lina Gu, Ying Sun, Tingjie Bai, Sijie Shao, Shumin Tang, Panpan Xue, Wanlin Cai, Xian Qin, Xuemei Zeng and Shuangqian Yan

    Citation: Journal of Nanobiotechnology 2025 23:212

    Content type: Research Published on: 15 March 2025

  • Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention

    Nickel-based nanomaterials (NBNs) have seen a surge in usage across a variety of applications. However, the widespread use of NBNs has led to increased human exposure, raising questions about their associated ...

    Authors: Xiaoting Zhou, Jiaqi Liao, Zipeng Lei, Huiqin Yao, Le Zhao, Chun Yang, Yan Zu and Yuliang Zhao

    Citation: Journal of Nanobiotechnology 2025 23:211

    Content type: Review Published on: 14 March 2025

  • Retraction Note: Eobania vermiculata whole-body muscle extract-loaded chitosan nanoparticles enhanced skin regeneration and decreased pro-inflammatory cytokines in vivo

    Authors: Alyaa Farid, Adham Ooda, Ahmed Nabil, Areej Nasser, Esraa Ahmed, Fatma Ali, Fatma Mohamed, Habiba Farid, Mai Badran, Mariam Ahmed, Mariam Ibrahim, Mariam Rasmy, Martina Saleeb, Vereena Riad, Yousr Ibrahim and Neveen Madbouly

    Citation: Journal of Nanobiotechnology 2025 23:210

    Content type: Retraction Note Published on: 14 March 2025

  • Development of NIR photocleavable nanoparticles with BDNF for vestibular neuron regeneration

    Among nanoparticle platforms, light or photoresponsive nanoparticles have emerged as a promising drug delivery strategy with spatiotemporal control while minimizing off-target effects. The characteristic absor...

    Authors: Celine DG. Abueva, Sung Ryeong Yoon, Nathaniel T. Carpena, Seung Cheol Ahn, So-Young Chang, Ji Eun Choi, Min Young Lee and Jae Yun Jung

    Citation: Journal of Nanobiotechnology 2025 23:209

    Content type: Research Published on: 13 March 2025

  • Macrophage-derived mitochondria-rich extracellular vesicles aggravate bone loss in periodontitis by disrupting the mitochondrial dynamics of BMSCs

    Periodontitis is the leading cause of tooth loss in adults due to progressive bone destruction, which is closely related to the dysfunction of bone mesenchymal stem cells (BMSCs). Existing evidence suggests th...

    Authors: Jiayin Yan, Tian Yang, Siyuan Ma, Danfeng Li, Cheng Hu and Jiali Tan

    Citation: Journal of Nanobiotechnology 2025 23:208

    Content type: Research Published on: 12 March 2025

  • Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation

    While radiotherapy-induced immunogenic cell death (ICD) holds potential for enhancing cancer immunotherapy, the conventional high-dose irradiation often leads to an immunosuppressive microenvironment and syste...

    Authors: Weijie Zhuang, Kuangwu Pan, Jie Wu, Leyi Liu, Shiyu Lv, Jiajun Hu, Fangyang Shi, Wei Zhao and Dongsheng Yu

    Citation: Journal of Nanobiotechnology 2025 23:207

    Content type: Research Published on: 12 March 2025

  • Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity

    Excessive generation of reactive oxygen species is a hallmark of the osteoporotic bone microenvironment, which leads to the damage of mitochondrial function and the deactivation of osteoblasts. Fruits and vege...

    Authors: Jiao Peng, Rongyan Liu, Junyi Xu, Yingjuan Yao, Beibei Li, Dengke Chen, Zhuangpeng Chang, Rui Zhao, Yanlin Feng, Ruigang Hou, Min Lee and Xiao Zhang

    Citation: Journal of Nanobiotechnology 2025 23:206

    Content type: Research Published on: 12 March 2025

  • Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment

    Periodontitis, a chronic inflammatory disease caused by bacteria, is characterized by localized reactive oxygen species (ROS) accumulation, leading to an inflammatory response, which in turn leads to the destr...

    Authors: Yujing Zhu, Ziliang Xiu, Xiaoxi Jiang, Huifang Zhang, Xiaofeng Li, Yunru Feng, Bojiang Li, Rui Cai, Chunhui Li and Gang Tao

    Citation: Journal of Nanobiotechnology 2025 23:205

    Content type: Research Published on: 12 March 2025

  • CREB1/CRTC2 regulated tubular epithelial-derived exosomal miR-93-3p promotes kidney injury induced by calcium oxalate via activating M1 polarization and macrophage extracellular trap formation

    Calcium oxalate (CaOx) crystals are known to cause renal injury and trigger inflammatory responses. However, the role of exosome-mediated epithelial-macrophage communication in CaOx-induced kidney injury remai...

    Authors: Yushi Sun, Bojun Li, Baofeng Song, Yuqi Xia, Xiangjun Zhou, Fangyou Lin, Ting Rao and Fan Cheng

    Citation: Journal of Nanobiotechnology 2025 23:204

    Content type: Research Published on: 12 March 2025

  • MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy

    Radiotherapy (RT) effectiveness is limited by low DNA damage in tumor cells, surrounding tissue harm, and tumor radioresistance with active DNA repair. Herein, we have engineered a two-dimensional nanomaterial...

    Authors: Huan Zhu, Zhaoyuan Zhang, Rong Jiang, Liangfu Xu, Xiangdi Yang, Jie Chen, Zhenning Wang, Xiao Xu and Zhigang Liu

    Citation: Journal of Nanobiotechnology 2025 23:203

    Content type: Research Published on: 11 March 2025

  • Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction

    Mitochondria are pivotal in sustaining oxidative balance and metabolic activity within neurons. It is well-established that mitochondrial dysfunction constitutes a fundamental pathogenic mechanism in neurodege...

    Authors: Shizheng Zhang, Mengmeng Li, Yuan Li, Shike Yang, Jian Wang, Xiaoxiang Ren, Xiuhui Wang, Long Bai, Jianping Huang, Zhen Geng, Guosheng Han, Yibin Fang and Jiacan Su

    Citation: Journal of Nanobiotechnology 2025 23:202

    Content type: Research Published on: 11 March 2025

  • Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction

    Neuroinflammation triggered by microglia activation is hallmark of autism spectrum disorder (ASD), and this process includes crucial metabolic reprogramming from oxidative phosphorylation to glycolysis, which ...

    Authors: Qian Qin, Linlin Fan, Xin Zeng, Danyang Zheng, Han Wang, Mengyue Li, Yutong Jiang, Hui Wang, Hao Liu, Shengjun Liang, Lijie Wu and Shuang Liang

    Citation: Journal of Nanobiotechnology 2025 23:201

    Content type: Research Published on: 11 March 2025

  • Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin

    Alterations in intercellular communication driven by cellular senescence constitute an important factor in skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates in intercellul...

    Authors: Hanlin Tu, Yingliang Shi, Yi Guo, Zhongyang Zou, Yuyan He, Jing Zhou, Sangang He and Guoliang Sa

    Citation: Journal of Nanobiotechnology 2025 23:200

    Content type: Research Published on: 11 March 2025

  • Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration

    Optimizing the immune microenvironment is essential for successful implant osseointegration. In this study, four different nano/microstructures were fabricated on polyetheretherketone (PEEK) substrates by vary...

    Authors: Yuqing Zhao, Yanxin An, Fan Wu, Lipeng Liu, Franklin R. Tay, Yang Jiao and Jing Wang

    Citation: Journal of Nanobiotechnology 2025 23:199

    Content type: Research Published on: 11 March 2025

  • Ginseng exosomes modulate M1/M2 polarisation by activating autophagy and target IKK/IкB/NF-кB to alleviate inflammatory bowel disease

    Exosomes are involved in intercellular communication and regulation of the inflammatory microenvironment. In a previous study, we demonstrated that fresh ginseng exosomes (GEs) alleviated inflammatory bowel di...

    Authors: Song Yang, Liangliang Fan, Lijia Yin, Yueming Zhao, Wenjing Li, Ronghua Zhao, Xuxia Jia, Fusong Dong, Ze Zheng, Daqing Zhao and Jiawen Wang

    Citation: Journal of Nanobiotechnology 2025 23:198

    Content type: Research Published on: 10 March 2025

  • Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy

    The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, ...

    Authors: Hongyu Chu, Yajun Xu, Yuezhan Shan, Mengmeng Sun, Weidong Zhao, Xuedong Fang, Na Shen and Zhaohui Tang

    Citation: Journal of Nanobiotechnology 2025 23:197

    Content type: Research Published on: 10 March 2025

  • A bivalent spike-targeting nanobody with anti-sarbecovirus activity

    The continued emergence and zoonotic threat posed by coronaviruses highlight the urgent need for effective antiviral strategies with broad reactivity to counter new emerging strains. Nanobodies (or single-doma...

    Authors: Iris C. Swart, Oliver J. Debski-Antoniak, Aneta Zegar, Thijs de Bouter, Marianthi Chatziandreou, Max van den Berg, Ieva Drulyte, Krzysztof Pyrć, Cornelis A. M. de Haan, Daniel L. Hurdiss, Berend-Jan Bosch and Sabrina Oliveira

    Citation: Journal of Nanobiotechnology 2025 23:196

    Content type: Research Published on: 10 March 2025

  • Renal-clearable and tumor-retained nanodots overcoming metabolic reprogramming to boost mitochondrial-targeted photodynamic therapy in triple-negative breast cancer

    Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such a combination therapeutic regimen has enc...

    Authors: Defan Yao, Yanshu Wang, Xue Dong, Yanhong Chen, Ding-Kun Ji, Rongfeng Zou, Yuelin Huang, Weixi Huang and Dengbin Wang

    Citation: Journal of Nanobiotechnology 2025 23:195

    Content type: Research Published on: 10 March 2025

  • Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity

    Immune checkpoint inhibition (ICI) has become the mainstay of immunotherapy for the treatment of renal cell carcinoma (RCC). However, only a small portion of patients exhibit a positive response to PD-1/PD-L1 ...

    Authors: Yanhong Liu, Liming Gong, Jing Feng, Congcong Xiao, Chenfei Liu, Bohan Chen, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao and Wei Huang

    Citation: Journal of Nanobiotechnology 2025 23:194

    Content type: Research Published on: 10 March 2025

  • Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance

    Despite the availability of a series of classical antibiotic drugs, bacterial infections continue to represent a significant and urgent threat to global human health. The emergence of drug-resistant bacteria a...

    Authors: Chuanda Zhu, Zhenli Diao, Yuanyuan Yang, Jun Liao, Chao Wang, Yanglonghao Li, Zichao Liang, Pengcheng Xu, Xinyu Liu, Qiang Zhang, Lidong Gong, Qiang Ma, Ling Liang and Zhiqiang Lin

    Citation: Journal of Nanobiotechnology 2025 23:193

    Content type: Review Published on: 9 March 2025

  • Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications

    The liver, functioning as an endocrine organ, secretes a variety of substances that influence the activities of other body organs. Conversely, molecules generated by organs such as bone, the gut, and adipose t...

    Authors: Wenhui Mo, Yunke Peng, Yanyi Zheng, Shenglan Zhao, Liling Deng and Xiaoli Fan

    Citation: Journal of Nanobiotechnology 2025 23:190

    Content type: Review Published on: 8 March 2025

  • Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy

    Periodontitis is a chronic inflammatory disease caused by plaque. In order to remove pathogens and promote tissue repair, the following steps need to be taken simultaneously: localizing the diseased area, impr...

    Authors: Suai Lin, Tiehan Cui, Yuxin Jiang, Jialiang Xie, Da Zhong, Junkai Jiang, Dan Deng, Mengzhen Zhao, Chengzhou Xue, Shiyu Gan, Jiaxuan Qiu and Xiaolei Wang

    Citation: Journal of Nanobiotechnology 2025 23:189

    Content type: Research Published on: 8 March 2025

  • Probiotic nanocomposite materials with excellent resistance, inflammatory targeting, and multiple efficacies for enhanced treatment of colitis in mice

    The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading to excessive production of reactive oxygen species (ROS...

    Authors: Yuewen Huang, Hongting Cai, Huipeng Liu, Lixiang Wang, Guangfu Feng, Zizi Ding, Yanquan Fei, Aike Li and Jun Fang

    Citation: Journal of Nanobiotechnology 2025 23:188

    Content type: Research Published on: 8 March 2025