Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications - Journal of Nanobiotechnology
- ️Min, Li
- ️Mon Sep 05 2022
TME cells | Sarcoma type | Exosomal cargos | Mechanisms | Clinical significance | References |
|---|---|---|---|---|---|
TAMs | OS | \ | Promote anti-tumor response; activate caspase-3 and -7 | Progression↓ | [51] |
TAMs | OS | miR-221-3p | Activate JAK2/STAT3 pathway | Progression and metastasis↑ | [52] |
TAMs | OS | lncRNA LIFR-AS1 | Activate miR-29a/NFIA axis | Progression and metastasis↑ | [53] |
MSCs | OS | \ | Decrease hsa-miR-195 and hsa-miR-124, increase hsa-miR-148a | Progression and metastasis↑ | [60] |
MSCs | OS | miR-21-5p | Activate PI3K/Akt/mTOR pathway | Progression↑ | [61] |
ADSC | OS | \ | Up-regulate COLGALT2, vimentin, and MMP2/9 | Progression and metastasis↑ | [62] |
MSCs | OS | \ | Activate Hedgehog pathway | Progression↑ | [63] |
MSCs | OS | miRNA-208a | Activate ERK1/2 pathway | Progression and metastasis↑ | [64] |
MSCs | ATRT | miR-155 | Down-regulate SMARCA4 | Metastasis↑ | [65] |
MSCs | OS | lncRNA PVT1 | Increase ERG level | Progression and metastasis↑ | [66] |
CAFs | OS | lncRNA SNHG17 | Activate miR-2861/MMP2 axis | Progression↑ | [71] |
OS cells | OS | uPA | Activate uPA/uPAR axis | Metastasis↑ | [69] |
EWS cells | EWS | miR-210 | Down-regulate CASP8AP2 | Progression↑ | [28] |
OS cells | OS | hsa-circ-103801 | Reduce cisplatin sensitivity, inhibit apoptosis, and increase MRP-1 and P-glycoprotein expression | Chemoresistance↑ | [91] |
OS cells | OS | MDR-1 mRNA, P-glycoprotein | Increase MDR-1 mRNA, P-glycoprotein | Chemoresistance↑ | [96] |