Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis - Diabetologia
- ️Fogarty, D. G.
- ️Sat Feb 07 2009
Table 1 Characteristics of ten studies included in the meta-analysis
First author [reference no.] | Year | Country | Hyperfiltration definition (ml min−1 1.73 m−2)a | Patients included (n) | Mean age at diagnosis(years) | Mean follow-up (years) | Mean baseline diabetes duration (years) | Mean baseline HbA1c (%) | Mean baseline blood pressure (mmHg) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
Progression | No progression | Progression | No progression | ||||||||
Mogensen [22] | 1984 | Denmark | ND | 24 | 12.3 | 10.4 | 12.6 | 6.9b | 7.4b | 135/89 | 124/80 |
Lervang [23] | 1988 | Denmark | ND | 29 | 18.9 | 18.5 | 3.4 | 9.3b | 7.2b | 118/76 | 119/76 |
Lervang [24] | 1992 | Denmark | ND | 34 | 7.0 | 12.0 | 7.0 | 10.8b | 9.0 | 128/83 | 115/70 |
Chiarelli [25] | 1995 | Italy | 140 c | 46 | 6.2 | 10.0 | 9.7 | 12.2d | 9.5d | NA | NA |
Yip [26] | 1996 | England | 135 | 45 | 21.5 | 9.5 | 8.0 | NA | NA | NA | NA |
Caramori [27] | 1999 | Brazil | 134 c | 33 | 25.3 | 8.4 | 6.5 | 11.4d | 9.9d | NA | NA |
Dahlquist [28] | 2001 | Sweden | 125 | 43 | 6.0 | 18.0 | 10.9 | 12.2 | 12.0 | 121/74 | 115/74 |
Amin [29] | 2005 | England | 125 | 273 | 9.3 | 10.9 | 5.1 | 10.8 | 9.7 | NA | NA |
Steinke [30] | 2005 | USA | 130 | 107 | 8.7 | 5.0 | 8.0 | 9.2 | 8.4 | 114/64 | 114/64 |
Zerbini [31] | 2006 | Italy | ND | 146 | 7.3 | 9.5 | 9.5 | 9.8 | 9.0 | 119/74 | 118/74 |
Total | 780 | ||||||||||
Mean | 12. 3 | 11.2 | 8.1 | 10.5 | 9.6 | 123/77 | 118/73 |
- aWhere not defined (ND), arbitrarily set at >140 ml min−1 1.73 m−2
- bHbA1c estimated using reverse estimated average glucose formula (these values omitted when calculating mean)
- cSingle compartment GFR estimation technique
- dHbA1 measurements (these values omitted when calculating mean)
- NA, not available