Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet - Diabetologia

HFD regulation of tissue Tlr1, -2, -4 and -6 mRNA expression. a Relative tissue expression profile of mouse Tlr2 mRNA based on 430 2.0 mouse Affymetrix gene arrays (n = 3 for all tissues except islet, bone marrow and pituitary, where n = 4). b Female C57BL/6J littermate mice were fed an HFD for 20 weeks starting at 10–12 weeks of age. Perigonadal adipose tissue, quadriceps skeletal muscle, liver tissue, isolated pancreatic islets and circulating leucocytes were isolated and analysed for Tlr expression by quantitative PCR (chow n = 7, HFD n = 8). White bars, Tlr1; light grey bars, Tlr2; black bars, Tlr6; dark grey bars, Tlr4. *p < 0.05, as tested by Student’s t test compared with chow-fed age-matched control (1.0 ± SEM)

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