No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY) - Diabetologia
- ️Norris, J. M.
- ️Sat Aug 20 2011
Characteristic | Study 1a: vitamin D intake | Study 1b: 25(OH)D | Study 1c: 25(OH)D at 9 months | ||||||
|---|---|---|---|---|---|---|---|---|---|
Children positive for IA (n = 123) | Children negative for IA (n = 1,752) | p value | Children positive for IA (n = 88) | Children negative for IA (n = 353) | p value | Children positive for IA (n = 30) | Children negative for IA (n = 98) | p value | |
Age at last visit or first IA positive visit, mean (SD) | 6.4 (3.4) | 8.8 (4.4) | N/A | 5.5 (3.2) | 9.0 (4.7) | N/A | 3.5 (2.6) | 7.3 (4.0) | N/A |
Female sex, n (%) | 59 (48) | 841 (48) | 0.99 | 44 (50) | 173 (49) | 0.87 | 17 (57) | 48 (49) | 0.46 |
Non-Hispanic white ethnicity, n (%) | 96 (78) | 1,316 (71) | 0.52 | 71 (81) | 257 (73) | 0.13 | 25 (83) | 72 (73) | 0.27 |
HLA-DR3/4, DQB1*0302 genotype, n (%) | 44 (36) | 376 (21) | 0.0002 | 32 (36) | 94 (27) | 0.07 | 10 (33) | 40 (41) | 0.46 |
Family history of T1D, n (%) | 74 (60) | 870 (50) | 0.024 | 48 (55) | 126 (36) | 0.0012 | 16 (53) | 48 (49) | 0.68 |
Blood drawn from May to October, n (%) | N/A | 46 (52) | 199 (56) | 0.49 | 16 (53) | 49 (50) | 0.75 |