Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition - Psychopharmacology

Inhibition of GSK3 with SB216763 did not impair reconsolidation of fear memories. Mice underwent training for contextual fear conditioning. SB 216763, 2.5, or 5 mg/kg, or vehicle was administered immediately after the test for contextual fear conditioning; re-testing occurred 24 h later. No difference in the amount of time spent freezing to the context between vehicle and SB 216763-injected groups was found. Data were analyzed by two-way ANOVA and are expressed as means + SEM of percent time spent freezing during the 5-min test session (N = 12/group)

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