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Intensive chemotherapy with autologous bone marrow transplantation for small-cell lung cancer - Cancer Chemotherapy and Pharmacology

  • ️Tobias, J. S.
  • ️Sun Oct 01 1989

Summary

Since 1980, 75 patients with small-cell lung cancer (SCLC) have been entered into four consecutive studies of high-dose chemotherapy using autologous bone marrow transplantation (ABMT) to assist haematological recovery. In the first study, 25 patients were treated with cyclophosphamide (160–200 mg/kg) as the sole chemotherapy; in the second (26 patients), the cycle of high-dose cyclophosphamide (with or without 800–1,200 mg/m2 etoposide) was repeated as induction treatment. In the first study, response was high [14 complete responses (CR), 7 partial responses (PR)] but was not increased by repeating the cycle (15 CR, 8 PR), and survival was slightly worse in the second trial. In the third study, 15 patients were treated with doxorubicin, vincristine and etoposide for two cycles and then with 200 mg/kg cyclophosphamide. Although high-dose cyclophosphamide increased the complete response rate, the additional responses were short-lived. In the final study, an attempt was made to increase the initial CR rate by combination chemotherapy using carboplatin (400–600 mg/m2), etoposide (120 mg/ m2x4) and either high-dose cyclophosphamide (40 mg/kg x4) or melphalan (140 mg/m2). Although all nine patients responded, none underwent a CR. The long-term survival (up to 7 years) does not appear to be different from that in comparably selected cases treated with conventional chemotherapy.

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Authors and Affiliations

  1. Department of Oncology, University College and Middlesex School of Medicine, 91 Riding House Street, W1P 8BT, London

    R. L. Souhami, H. T. Hajichristou, D. W. Miles, H. M. Earl, C. M. Ash, A. H. Goldstone & J. S. Tobias

  2. Department of Medical Oncology, Guy's Hospital, St Thomas' Street, W6 9RT, London, UK

    P. G. Harper

  3. Brompton Hospital, Fulham Road, SW3 6HB, London, UK

    S. G. Spiro

  4. London Chest Hospital, Bonner Road, E2 9JX, London, UK

    D. M. Geddes

Authors

  1. R. L. Souhami

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  2. H. T. Hajichristou

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  3. D. W. Miles

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  4. H. M. Earl

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  5. P. G. Harper

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  6. C. M. Ash

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  7. A. H. Goldstone

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  8. S. G. Spiro

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  9. D. M. Geddes

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  10. J. S. Tobias

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Additional information

This work was supported by the Cancer Research Campaign

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Souhami, R.L., Hajichristou, H.T., Miles, D.W. et al. Intensive chemotherapy with autologous bone marrow transplantation for small-cell lung cancer. Cancer Chemother. Pharmacol. 24, 321–325 (1989). https://doi.org/10.1007/BF00304766

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  • Received: 15 October 1988

  • Accepted: 24 February 1989

  • Issue Date: October 1989

  • DOI: https://doi.org/10.1007/BF00304766

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