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Multiple myeloma among blacks and Whites in the United States: the role of chronic antigenic stimulation - Cancer Causes & Control

  • ️Hoover, Robert N.
  • ️Tue Nov 01 1994

Abstract

Multiple myeloma (MM) is twice as common among Blacks than Whites in the United States. The reasons for this racial disparity are unknown, and the etiology of this cancer in general, is poorly understood. Repeated or chronic antigenic stimulation (CAS) of the immune system has been suggested as a risk factor. Previous case-control studies have reported inconsistent CAS associations based on evaluations of individual and biologic categories of medical conditions. Interview data from 573 cases and 2,131 population-based controls were used to investigate further the CAS hypothesis using an immunologically based approach, and to determine whether CAS accounts for the excess of myeloma among Blacks. Over 50 medical conditions were grouped into biologically and immunologically related categories, and B-cell-and T-cell-mediated response groups. Except for urinary tract infections among Black men (odds ratio [OR]=2.0), no significantly increased risks of MM were observed. However, there was a suggestion of increased risk among Blacks with an increased exposure to anaphylatic conditions. Analysis by immunoglobulin type revealed significantly elevated risks of IgG myeloma with eczema (OR=2.1), the biologic category ‘allergic conditions” (OR=1.6), and the immunologic category ‘anaphylaxis response’ (OR=1.6) among Whites, with Blacks having slightly lower risks. Our findings do not support a causal relationship between CAS and MM, nor do they explain the higher incidence among Blacks.

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Authors and Affiliations

  1. Epidemiology Branch, Health Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC, USA

    Denise Riedel Lewis

  2. Epidemiology and Biostatistics Program at the US National Cancer Institute, EPN Room 418, 6130 Executive Blvd., MSC-7364, Bethesda, MD, 20892-7264, USA

    Linda M. Pottern,  Linda Morris Brown,  Debra T. Silverman, Richard B. Haves & Robert N. Hoover

  3. Special Epidemiology Program at the New Jersey Department of Health, Trenton, NJ, USA

    Janet B. Schoenberg

  4. Division of Epidemiology, School of Public Health at Emory University, Atlanta, GA, USA

    Raymond S. Greenberg & Jonathan M. Liff

  5. College of Human Medicine at Michigan State University, East Lansing, MI, USA

    G. Marie Swanson

  6. Department of Clinical Epidemiology and Family Medicine at the University of Pittsburgh, Pittsburgh, PA, USA

    Ann Grossbart Schwartz

Authors

  1. Denise Riedel Lewis

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  2. Linda M. Pottern

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  3. Linda Morris Brown

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  4. Debra T. Silverman

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  5. Richard B. Haves

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  6. Janet B. Schoenberg

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  7. Raymond S. Greenberg

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  8. G. Marie Swanson

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  9. Ann Grossbart Schwartz

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  10. Jonathan M. Liff

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  11. Robert N. Hoover

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Additional information

This research was funded under comtracts NO1-CP-51090, NO1-CN-0522, NO1-CP-51089, NO1-CN-31022, NO1-CP-51092, NO1-CN-05227 from the US National Cancer Institute.

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Lewis, D.R., Pottern, L.M., Brown, L.M. et al. Multiple myeloma among blacks and Whites in the United States: the role of chronic antigenic stimulation. Cancer Causes Control 5, 529–539 (1994). https://doi.org/10.1007/BF01831381

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  • Received: 23 May 1994

  • Accepted: 15 August 1994

  • Issue Date: November 1994

  • DOI: https://doi.org/10.1007/BF01831381

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