medicalguidelines.msf.org

TINIDAZOLE oral | MSF Medical Guidelines

Prescription under medical supervision

Therapeutic action

  • Antiprotozoal, antibacterial (group of nitroimidazoles)

Indications

  • Amoebiasis, giardiasis, trichomoniasis
  • Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp)

Forms and strengths

  • 500 mg tablet

Dosage and duration

Amoebiasis

  • Child: 50 mg/kg once daily (max. 2 g daily)
  • Adult: 2 g once daily

The treatment lasts 3 days in intestinal amoebiasis; 5 days in hepatic amoebiasis.

Giardiasis, trichomoniasis and bacterial vaginitis

  • Child: 50 mg/kg single dose (max. 2 g)
  • Adult: 2 g single dose

In the event of trichomoniasis, also treat sexual partner.

Infections due to anaerobic bacteria

  • Child over 12 years and adult: 2 g on D1 then 1 g once daily or 500 mg 2 times daily

According to indication, tinidazole may be used in combination with other antibacterials; treatment duration depends on indication.

Contra-indications, adverse effects, precautions

  • Do not administer to patients with allergy to tinidazole or another nitroimidazole (metronidazole, secnidazole, etc.).
  • May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness. Risk of antabuse reaction when combined with alcohol.
  • Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin (increased plasma concentrations of these drugs).
  • Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.
  • Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants); divide into smaller doses, avoid prolonged use.

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