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The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis - Molecular Psychiatry

  • ️Ebrahim, S
  • ️Tue Jan 10 2006

  • Bottiglieri T, Hyland K, Reynolds EH . The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994; 48: 137–152.

    Article  CAS  Google Scholar 

  • Mattson M, Shea T . Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003; 23: 137.

    Article  Google Scholar 

  • Paul RTP, McDonnell AP, Kelly CB . Folic acid: neurochemistry, metabolism and relationship to depression. Hum Psychopharmacol Clin Exp 2004; 19: 477–488.

    Article  CAS  Google Scholar 

  • Morris MS, Fava M, Jacques PF, Selhub J, Rosenberg IH . Depression and folate status in the US population. Psychother Psychosom 2003; 72: 80–87.

    Article  Google Scholar 

  • Guaraldi GP, Fava M, Mazzi F, la Greca P . An open trial of methyletrahydrofolate in elderly depressed patients. Ann Clin Psychiatry 1993; 5: 101–105.

    Article  CAS  Google Scholar 

  • Taylor MJ, Carney SM, Goodwin GM, Geddes JR . Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol 2004; 18: 251–256.

    Article  CAS  Google Scholar 

  • Nemeroff C . Progress in the battle with the black dog: advances in the treatment of depression. Am J Psychiatry 2001; 158: 1555–1557.

    Article  CAS  Google Scholar 

  • Ray JG, Meier C, Vermeulen MJ, Boss S, Wyatt PR, Cole DE . Association of neural tube defects and folic acid food fortification in Canada. Lancet 2002; 360: 2047–2048.

    Article  Google Scholar 

  • Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY . Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001; 285: 2981–2986.

    Article  CAS  Google Scholar 

  • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111–113.

    Article  CAS  Google Scholar 

  • Kluijtmans L, Young IS, Boreham C, Murray L, McMaster D, McNulty H et al. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003; 101: 2483–2488.

    Article  CAS  Google Scholar 

  • Sunder-Plassmann G, Fodinger M . Genetic determinants of the homocysteine level. Kidney Int Suppl 2003; 84: S141–S144.

    Article  CAS  Google Scholar 

  • Geisel J, Hubner U, Bodis M . The role of genetic factors in the development of hyperhomocysteinemia. Clin Chem Lab Med 2003; 41: 1427–1434.

    CAS  PubMed  Google Scholar 

  • Davey Smith G, Ebrahim S . ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003; 32: 1–22.

    Article  Google Scholar 

  • Botto LD, Yang Q . 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 2000; 151: 862–877.

    Article  CAS  Google Scholar 

  • Reif A, Pfuhlmann B, Lesch KP . Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 1162–1168.

    Article  CAS  Google Scholar 

  • Almeida OP, Flicker L, Lautenschlager NT, Leedman P, Vasikaran S, van Bockxmeer FM . Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiol Aging 2005; 26: 251–257.

    Article  CAS  Google Scholar 

  • Kelly CB, McDonnell AP, Johnston TG, Mulholland C, Cooper SJ, McMaster D et al. The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. J Psychopharmacol 2004; 18: 567–571.

    Article  CAS  Google Scholar 

  • Tan EC, Chong SA, Lim LC, Chan AO, Teo YY, Tan CH et al. Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders. Psychiatr Genet 2004; 14: 227–231.

    Article  Google Scholar 

  • Bjelland I, Tell GS, Vollset SE, Refsum H, Ueland PM . Folate, vitamin B12, homocysteine, and the MTHFR 677C-T polymorphism in anxiety and depression. Arch Gen Psychiatry 2003; 60: 618–626.

    Article  CAS  Google Scholar 

  • Hickie I, Scott E, Naismith S, Ward PB, Turner K, Parker G et al. Late-onset depression: genetic, vascular and clinical contributions. Psychol Med 2001; 31: 1403–1412.

    Article  CAS  Google Scholar 

  • Kunugi H, Fukuda R, Hattori M, Kato T, Tatsumi M, Sakai T et al. C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses. Mol Psychiatry 1998; 3: 435–437.

    Article  CAS  Google Scholar 

  • Arinami T, Yamada N, Yamakawa-Kobayashi K, Hamaguchi H, Toru M . Methylenetetrahydrofolate reductase variant and schizophrenia/depression. Am J Med Genet 1997; 74: 526–528.

    Article  CAS  Google Scholar 

  • Lawlor DA, Bedford C, Taylor M, Ebrahim S . Geographic variation in cardiovascular disease, risk factors and their control in older women: British Women's Heart and Health Study. J Epidemiol Community Health 2003; 57: 134–140.

    Article  CAS  Google Scholar 

  • Miller SA, Dykes DD, Polesky HF . A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.

    Article  CAS  Google Scholar 

  • Sterne JAC, Bradburn MJ, Egger M . Meta-analysis in Stata. In: Egger M, Davey Smith G and Altman D (eds). Systematic Reviews in Health Care: Meta-Analysis in Context, 2nd edn. BMJ: London, 2001; 347–369.

    Chapter  Google Scholar 

  • Erens B, Primatesta P . Health Survey for England 1998: Cardiovascular Disease. The Stationary Office: London, 1999.

    Google Scholar 

  • Shrubsole MJ, Jin F, Dai Q, Shu XO, Potter JD, Hebert JR et al. Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Res 2001; 61: 7136–7141.

    CAS  PubMed  Google Scholar 

  • Sellers TA, Kushi LH, Cerhan JR, Vierkant RA, Gapstur SM, Vachon CM et al. Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology 2001; 12: 420–428.

    Article  CAS  Google Scholar 

  • Wilcken DE, Wang XL, Sim AS, McCredie RM . Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation. Arterioscler Thromb Vasc Biol 1996; 16: 878–882.

    Article  CAS  Google Scholar 

  • Knight JC, McGuire W, Kortok MM, Kwiatkowski D . Accuracy of genotyping of single-nucleotide polymorphisms by PCR-ELISA allele-specific oligonucleotide hybridization typing and by amplification refractory mutation system. Clin Chem 1999; 45: 1860–1863.

    CAS  PubMed  Google Scholar 

  • Brattstrom L, Wilcken DE, Ohrvik J, Brudin L . Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520–2526.

    Article  CAS  Google Scholar 

  • Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. Br Med J 1998; 316: 894–898.

  • Colhoun HM, McKeigue PM, Davey Smith G . Problems of reporting genetic associations with complex outcomes. Lancet 2003; 361: 865–872.

    Article  Google Scholar