Online Mendelian Inheritance in Man (OMIM)
- ️Wed Dec 07 2005
% 609402
PREECLAMPSIA/ECLAMPSIA 2; PEE2
ORPHA: 275555; DO: 10591;
Cytogenetic location: 2p25 Genomic coordinates (GRCh38) : 2:1-12,000,000
Gene-Phenotype Relationships
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 2p25 | Preeclampsia/eclampsia 2 | 609402 | 2 |
TEXT
For a general phenotypic description and a discussion of genetic heterogeneity of preeclampsia, see PEE1 (189800).
Mapping
Hypothesizing that the genetic background of preeclampsia might show reduced heterogeneity in a founder population such as that of the Kainuu province in central eastern Finland, Laivuori et al. (2003) performed a genomewide scan in 15 multiplex families in that area. They found 2 loci that exceeded the threshold for significant linkage: 2p25 (PEE2), at 21.70 cM, and 9p13 (PEE3; 609403), at 38.90 cM. They concluded that the susceptibility locus on 2p25 was clearly different from the locus (PEE1) at 2p13 found in the Icelandic study of Arngrimsson et al. (1999).
REFERENCES
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Arngrimsson, R., Siguroardottir, S., Frigge, M. L., Bjarnadottir, R. I., Jonsson, T., Stefansson, H., Baldursdottir, A., Einarsdottir, A. S., Palsson, B., Snorradottir, S., Lachmeijer, A. M. A., Nicolae, D., Kong, A., Bragason, B. T., Gulcher, J. R., Geirsson, R. T., Stefansson, K. A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum. Molec. Genet. 8: 1799-1805, 1999. [PubMed: 10441346] [Full Text: https://doi.org/10.1093/hmg/8.9.1799]
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Laivuori, H., Lahermo, P., Ollikainen, V., Widen, E., Haiva-Mallinen, L., Sundstrom, H., Laitinen, T., Kaaja, R., Ylikorkala, O., Kere, J. Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am. J. Hum. Genet. 72: 168-177, 2003. [PubMed: 12474145] [Full Text: https://doi.org/10.1086/345311]
Contributors:
Marla J. F. O'Neill - updated : 12/7/2005
Creation Date:
Anne M. Stumpf : 6/7/2005
Edit History:
carol : 07/11/2011
carol : 12/7/2005
terry : 12/7/2005
alopez : 6/9/2005
carol : 6/8/2005
alopez : 6/8/2005
alopez : 6/8/2005