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BRPI0414663A - substituted triazole derivatives as oxytocin antagonists - Google Patents

  • ️Tue Nov 21 2006

BRPI0414663A - substituted triazole derivatives as oxytocin antagonists - Google Patents

substituted triazole derivatives as oxytocin antagonists

Info

Publication number
BRPI0414663A
BRPI0414663A BRPI0414663-8A BRPI0414663A BRPI0414663A BR PI0414663 A BRPI0414663 A BR PI0414663A BR PI0414663 A BRPI0414663 A BR PI0414663A BR PI0414663 A BRPI0414663 A BR PI0414663A Authority
BR
Brazil
Prior art keywords
triazole derivatives
oxytocin antagonists
substituted triazole
substituted
oxytocin
Prior art date
2003-09-22
Application number
BRPI0414663-8A
Other languages
Portuguese (pt)
Inventor
Alan Daniel Brown
David Ellis
Christopher Ronald Smith
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2003-09-22
Filing date
2004-09-10
Publication date
2006-11-21
2003-09-22 Priority claimed from GB0322159A external-priority patent/GB0322159D0/en
2004-02-12 Priority claimed from GB0403150A external-priority patent/GB0403150D0/en
2004-07-05 Priority claimed from GB0415110A external-priority patent/GB0415110D0/en
2004-09-10 Application filed by Pfizer filed Critical Pfizer
2006-11-21 Publication of BRPI0414663A publication Critical patent/BRPI0414663A/en

Links

  • 239000003336 oxytocin antagonist Substances 0.000 title abstract 3
  • 229940121361 oxytocin antagonists Drugs 0.000 title abstract 3
  • 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title abstract 2
  • 239000003112 inhibitor Substances 0.000 abstract 2
  • 206010036596 premature ejaculation Diseases 0.000 abstract 2
  • NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical class C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
  • 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
  • 230000000694 effects Effects 0.000 abstract 1
  • 239000000203 mixture Substances 0.000 abstract 1
  • 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
  • 230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS TRIAZOL SUBSTITUìDOS COMO ANTAGONISTAS DE OXITOCINA". A presente invenção diz respeito a uma classe de 1,2,4-triazoles substituídos de fórmula (I) com actividade como antagonistas de oxitocina, suas utilizações, processos para a sua preparação e composições contendo os referidos inibidores. Estes inibidores têm utilidade numa multiplicidade de áreas terapêuticas incluindo disfunção sexual, particularmente ejaculação prematura (P.E.)."Triazole derivatives substituted as oxytocin antagonists". The present invention relates to a substituted 1,2,4-triazole class of formula (I) having oxytocin antagonist activity, their uses, processes for their preparation and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (PE).

BRPI0414663-8A 2003-09-22 2004-09-10 substituted triazole derivatives as oxytocin antagonists BRPI0414663A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0322159A GB0322159D0 (en) 2003-09-22 2003-09-22 New substituted triazoles for use as novel pharmaceuticals
GB0403150A GB0403150D0 (en) 2004-02-12 2004-02-12 Novel pharmaceuticals
GB0415110A GB0415110D0 (en) 2004-07-05 2004-07-05 Substituted triazole derivatives as oxytocin antagonists
PCT/IB2004/002977 WO2005028452A1 (en) 2003-09-22 2004-09-10 Substituted triazole derivatives as oxytocin antagonists

Publications (1)

Publication Number Publication Date
BRPI0414663A true BRPI0414663A (en) 2006-11-21

Family

ID=34381637

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414663-8A BRPI0414663A (en) 2003-09-22 2004-09-10 substituted triazole derivatives as oxytocin antagonists

Country Status (12)

Country Link
EP (1) EP1673355A1 (en)
JP (1) JP2007505888A (en)
AR (1) AR045791A1 (en)
BR (1) BRPI0414663A (en)
CA (1) CA2539297C (en)
MX (1) MXPA06003158A (en)
NL (1) NL1027084C2 (en)
PA (1) PA8613001A1 (en)
PE (1) PE20050950A1 (en)
TW (1) TW200526606A (en)
UY (1) UY28524A1 (en)
WO (1) WO2005028452A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745630B2 (en) 2003-12-22 2010-06-29 Justin Stephen Bryans Triazolyl piperidine arginine vasopressin receptor modulators
MX2007005940A (en) * 2004-11-18 2007-06-19 Synta Pharmaceuticals Corp Triazole compounds that modulate hsp90 activity.
AP2007004047A0 (en) * 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
EP1863795B1 (en) * 2005-03-21 2008-10-29 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
JP2008533193A (en) * 2005-03-21 2008-08-21 ファイザー・リミテッド Substituted triazole derivatives as oxytocin antagonists
NZ575512A (en) 2005-07-09 2009-11-27 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
CA2618103A1 (en) * 2005-08-10 2007-02-15 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
FR2903985B1 (en) 2006-07-24 2008-09-05 Sanofi Aventis Sa N- (AMINO-HETEROARYL) -1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2904316B1 (en) 2006-07-31 2008-09-05 Sanofi Aventis Sa N- (AMINO-HETEROARYL) -1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
DE102006059710A1 (en) * 2006-12-18 2008-06-19 Freie Universität Berlin Substituted 4-hydroxypyridines
FR2910473B1 (en) 2006-12-26 2009-02-13 Sanofi Aventis Sa N- (AMINO-HETEROARYL) -1H-PYRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
NZ592297A (en) 2008-09-22 2012-11-30 Cayman Chemical Co Inc 2-Aryl-5-heteroaryl pyridine and pyrimidine derivatives as pharmaceutical active agents
ES2716862T3 (en) 2014-12-22 2019-06-17 Ferring Bv Therapy with oxytocin receptor antagonists in the luteal phase for implantation and pregnancy in women undergoing assisted reproduction technologies
CN108884071B (en) * 2016-12-21 2021-05-14 江苏恒瑞医药股份有限公司 Condensed ring based azetidinyl triazole derivative, preparation method and application thereof in medicine
MX2019007360A (en) 2016-12-28 2019-08-16 Jiangsu Hengrui Medicine Co Azabicyclo-substituted triazole derivative, preparation method thereof, and application of same in medicine.
CN111094272B (en) * 2018-06-20 2022-05-27 江苏恒瑞医药股份有限公司 Pharmaceutically acceptable salt and crystal form of OTR inhibitor and preparation method
CN113004250B (en) * 2019-12-19 2022-07-26 上海森辉医药有限公司 Process for preparing substituted triazole derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000063363A (en) * 1998-08-12 2000-02-29 Yamanouchi Pharmaceut Co Ltd New triazole derivative
WO2001058880A1 (en) * 2000-02-08 2001-08-16 Yamanouchi Pharmaceutical Co., Ltd. Novel triazole derivatives
CA2409819C (en) * 2000-05-19 2009-09-15 Yamanouchi Pharmaceutical Co., Ltd. Triazole derivatives
ATE297913T1 (en) * 2001-07-05 2005-07-15 Pfizer Prod Inc SULFONYL-HETEROARYL-TRIAZOLES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS
SI1458381T1 (en) * 2001-12-20 2006-04-30 Applied Research Systems Triazoles as oxytocin antagonists

Also Published As

Publication number Publication date
AR045791A1 (en) 2005-11-16
WO2005028452A1 (en) 2005-03-31
PA8613001A1 (en) 2005-08-04
JP2007505888A (en) 2007-03-15
WO2005028452A9 (en) 2005-07-21
NL1027084A1 (en) 2005-03-24
EP1673355A1 (en) 2006-06-28
UY28524A1 (en) 2005-04-29
PE20050950A1 (en) 2005-11-11
MXPA06003158A (en) 2006-06-05
TW200526606A (en) 2005-08-16
NL1027084C2 (en) 2006-01-24
CA2539297A1 (en) 2005-03-31
CA2539297C (en) 2010-07-20

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Legal Events

Date Code Title Description
2011-04-05 B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
2012-07-10 B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 8A ANUIDADE.

2013-07-16 B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2166 DE 10/07/2012.