CN101336637B - Complex type broad-spectrum disinfectant and use thereof - Google Patents
- ️Wed Dec 07 2011
CN101336637B - Complex type broad-spectrum disinfectant and use thereof - Google Patents
Complex type broad-spectrum disinfectant and use thereof Download PDFInfo
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Publication number
- CN101336637B CN101336637B CN2008101980196A CN200810198019A CN101336637B CN 101336637 B CN101336637 B CN 101336637B CN 2008101980196 A CN2008101980196 A CN 2008101980196A CN 200810198019 A CN200810198019 A CN 200810198019A CN 101336637 B CN101336637 B CN 101336637B Authority
- CN
- China Prior art keywords
- disinfectant
- chlorhexidine
- complex type
- salt
- sodium diacetate Prior art date
- 2008-08-27 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000645 desinfectant Substances 0.000 title claims description 46
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 42
- 239000001632 sodium acetate Substances 0.000 claims abstract description 38
- OPGYRRGJRBEUFK-UHFFFAOYSA-L disodium;diacetate Chemical compound [Na+].[Na+].CC([O-])=O.CC([O-])=O OPGYRRGJRBEUFK-UHFFFAOYSA-L 0.000 claims abstract description 37
- 235000017454 sodium diacetate Nutrition 0.000 claims abstract description 37
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 230000007797 corrosion Effects 0.000 claims description 6
- 238000005260 corrosion Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 3
- 239000003974 emollient agent Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
- 229940050410 gluconate Drugs 0.000 claims description 2
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 19
- 239000002131 composite material Substances 0.000 abstract description 5
- 239000008367 deionised water Substances 0.000 description 21
- 229910021641 deionized water Inorganic materials 0.000 description 21
- 238000004659 sterilization and disinfection Methods 0.000 description 21
- 238000002360 preparation method Methods 0.000 description 18
- 239000012467 final product Substances 0.000 description 14
- 238000012856 packing Methods 0.000 description 13
- 238000013019 agitation Methods 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 229960002152 chlorhexidine acetate Drugs 0.000 description 8
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 229940087419 nonoxynol-9 Drugs 0.000 description 7
- 229920004918 nonoxynol-9 Polymers 0.000 description 7
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 235000019698 starch Nutrition 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 210000004666 bacterial spore Anatomy 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 239000000174 gluconic acid Substances 0.000 description 4
- 235000012208 gluconic acid Nutrition 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- IVKNZCBNXPYYKL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 IVKNZCBNXPYYKL-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 244000248349 Citrus limon Species 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 3
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- BRDJPCFGLMKJRU-UHFFFAOYSA-N DDAO Chemical compound ClC1=C(O)C(Cl)=C2C(C)(C)C3=CC(=O)C=CC3=NC2=C1 BRDJPCFGLMKJRU-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000004500 asepsis Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019249 food preservative Nutrition 0.000 description 1
- 239000005452 food preservative Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- -1 polyoxyethylene Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000011091 sodium acetates Nutrition 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses a composite broad spectrum sanitizer and an application thereof, belonging to the technical field of sanitizer. The active components of the sanitizer comprise chlorhexidine and the salt thereof and sodium diacetate. When the active components are dispersed in the dissolvent, the chlorhexidine and the salt thereof account for 0.001-5% of the total amount in weight percent, and the sodium diacetate accounts for 0.01-10% of the total amount. The sanitizer of the invention has the characteristics of good sterilizing effect, safe use, convenience and wide usage, and can be widely used for the skin-mucosa, the medical device, the sterilizing of the personal hygiene and the environment.
Description
Technical field
The present invention relates to a kind of disinfectant, more particularly, it relates to a kind of composite disinfection agent, the invention still further relates to this Application of disinfectants.
Background technology
Early stage medical disinfectant, usually adopt glutaraldehyde to carry out composite, as Chinese patent ZL96122359.6 (publication number CN1182533A, open day 1998.05.27) disclosed " preparation method of composite type medical disinfectant ", be exactly by glutaraldehyde, the Radix Glycyrrhizae derivative, non-ionic surface active agent, essence, deionized water is formed, this disinfectant can be directly used in the washing of various trauma patients, sterilization, simultaneously to the preoperative sterilization of medical worker, the sterilization of various medicine equipments, the sterilization of amenities all has the function and the cleaning function of very strong killing pathogenic bacteria, but glutaraldehyde has spread effect to mucous membrane, and it is smelly to distinguish the flavor of, and needs to add essence and covers.
And chlorhexidine and salt thereof are a kind of disinfectants commonly used, have stable performance, toxicity is little, cost is low characteristics, can kill Gram-positive (G +) and Gram-negative (G -) bacterial propagule, but tubercle bacillus, bacterial spore and some fungi thereof are only had inhibitory action, belong to low effect disinfectants.Use chlorhexidine and salt thereof technical scheme separately as disinfection composition, as Chinese patent ZL00111388.7 (publication number CN1345536A, open day 2002.04.24) disclosed " sterilizing liquid for dry washing hand ", adopt single chlorhexidine acetate as bactericide exactly, but the scope of sterilization is less relatively.Sterilize mucocutaneous and the immersion medicine equipment independent with chlorhexidine and salting liquid thereof, the possibility of may sterilize thorough and secondary infection.
Be to improve the sterilizing ability of chlorhexidine and salt thereof, normally adopt and carry out compositely with other disinfectant, for example chlorhexidine and salt thereof and quaternary ammonium salt are composite, chlorhexidine and salt thereof and iodine complexing, chlorhexidine and combinations such as salt and ethanolic solution thereof.This class technical scheme such as Chinese ZL01133553.X (publication number CN1343447A, open day 2002.04.10) disclosed " efficient sterilization disinfectant ", combined by chlorhexidine acetate and metronidazole exactly, widened its range of application, the disinfectant that can be used as a kind of wide spectrum uses.Chinese patent ZL02829642.7 (publication number CN1684711A and for example, open day 2005.10.19) disclosed " a kind of broad-spectrum disinfectant ", then form by alcohol, chlorhexidine gluconate, o-phenyl phenol, benzalkonium chloride etc., bactericidal range is extensive, but the benzalkonium chloride in the prescription should not be used for disinfecting of cystoscope, ophthalmological instruments and synthetic rubber articles, and its limitation is also arranged.
The present inventor finds, adds sodium Diacetate in chlorhexidine and salt thereof, can improve the sterilizing ability of chlorhexidine and salt thereof greatly, and sodium Diacetate is a kind of food preservative commonly used, its rat LD 50Be 4.86g/kg, allow addition 0.75～3g/kg in the food, belong to the environment-protecting asepsis bacteriostatic agent, G +And G -Bacterial propagule, bacterial spore and mould all have inhibitory action, its minimum inhibitory concentration (MIC) 0.5 ‰, the bacteriostasis of sodium Diacetate are because its molecular weight is little, easily penetrate bacterial cell wall and make it to take place damaged, cause the sex change of bacterial body internal protein, and reach antibacterial purpose.
Summary of the invention
The technical problem to be solved in the present invention is the difference at prior art, provides a kind of Disinfection Effect good, safe in utilization, convenient, broad-spectrum complex type broad-spectrum disinfectant.
The present invention also provides above-mentioned Application of disinfectants scope.
Last technical scheme of the present invention is such: a kind of complex type broad-spectrum disinfectant, the active component of this disinfectant comprises chlorhexidine and salt and sodium Diacetate, active component disperses the back to account for 0.001～5% of total amount in described chlorhexidine of weight ratio and salt thereof in solvent, and sodium Diacetate accounts for 0.01～10% of total amount.
In the above-mentioned complex type broad-spectrum disinfectant, described solvent is water, ethanol or their mixture.
In the above-mentioned complex type broad-spectrum disinfectant, described chlorhexidine and salt thereof account for 0.005～0.2% of total amount, and sodium Diacetate accounts for 0.02～1% of total amount.
In the above-mentioned complex type broad-spectrum disinfectant, the salt of described chlorhexidine is meant gluconate or acetate or hydrochloride or other salts.
In the above-mentioned complex type broad-spectrum disinfectant, described disinfectant can be solution, gel, tablet or wet tissue.
In the above-mentioned complex type broad-spectrum disinfectant, also contain the composition that one or more are selected from following material in this solution or the gel disinfectant, (1) surfactant, (2) viscosity modifier, (3) detergent, (4) corrosion inhibiter, (5) emollient, (6) aromatic.
Described surfactant can adopt foaming, detergency ability non-ionic surface active agent preferably, as alkylphenol polyoxyethylene etc., also can select to have the cationic surfactant of bactericidal effect, as quaternary or weak cation surfactant DDAO etc.Consumption is generally 0.1～1%.
As the hand lotion time spent, can add detergent, as Nonoxynol-9, consumption 0.1～0.5% can also add emollient usually, and as C12-15 alcohol benzoic ether, glycerine etc., addition is 0.5%～2% usually.
When using as air sanitizer, can add aromatic, as lemon extract, cream jasmin france etc., usual amounts is 0.01～0.1%.
When being used as the use of metal device disinfectant, can also add corrosion inhibitor, as the ONID corrosion inhibitor that ONID Technology (Shanghai) Corp produces, consumption is 1～3%.
Complex type broad-spectrum disinfectant of the present invention, its preparation method is also very simple, preparation method as solution can comprise the steps, under agitation slowly be dissolved in chlorhexidine and salt thereof and sodium Diacetate in the solvent, continuing to add other additive under the condition of stirring then, filter abundant dispersion back, packing gets final product.The preparation method of wet tissue is immersed in nonwoven, paper or cotton in the above-mentioned solution, and packing gets final product.And the preparation method of gel can comprise the steps, under agitation slowly be dissolved in chlorhexidine and salt thereof and sodium Diacetate in the solvent, continuing to add other additive under the condition of stirring then, fully disperse the back to filter, the carbomer that adds solution weight 0.1～0.5%, regulate pH value to 6.5 and form gel, packing gets final product.The preparation method of disinfectant tablet can comprise the steps, chlorhexidine and salt thereof and sodium Diacetate and compressing tablet auxiliary material sodium carboxymethyl starch, starch, talcum powder mixed, compressing tablet.
Above-mentioned complex type broad-spectrum disinfectant of the present invention can extensively be used in mucocutaneous, medical device, personal hygiene and environment disinfected.
Technical scheme of the present invention compared with prior art, under the less relatively situation of the consumption of chlorhexidine and salt thereof, can reach the good sterilization fungistatic effect, its key is to add the acting in conjunction of a spot of sodium Diacetate, improve the bactericidal range and the effect of chlorhexidine and salt thereof very significantly, according to experimental data as can be seen, under lower concentration, also can kill Gram-positive (G +) and Gram-negative (G -) bacterial propagule, bacterial spore, mould etc., becoming efficient sterilization disinfectant, purposes is very extensive, can be used as mucocutaneous, medical device, personal hygiene and environment disinfected goods and uses; Disinfectant of the present invention does not have the stink and the mucous membrane irritation of glutaraldehyde yet, more apparent green safety environmental protection efficacy; Disinfectant of the present invention adopts oxirane with steam medical device to be sterilized with tradition and compares, use also convenient, simple.
Embodiment
Below in conjunction with embodiment the present invention is described in further detail, but does not constitute any limitation of the invention.
Embodiment 1
Prescription: deionized water 4999g, chlorhexidine 0.5g, sodium Diacetate 0.5g.
Preparation method: under agitation chlorhexidine and sodium Diacetate slowly are dissolved in the deionized water, treat fully to disperse back filtration, packing to get final product.
Above-mentioned prescription can be used for preoperative both hands sterilization of doctor or preparation disinfection wet tissue.
Embodiment 2
Prescription: deionized water 4991g, chlorhexidine 0.5g, sodium Diacetate 1.0g, Nonoxynol-9 5g, glycerine 2.5g.
Preparation method: under agitation chlorhexidine and sodium Diacetate slowly are dissolved in the deionized water, are continuing to add Nonoxynol-9 and glycerine under the condition of stirring then, treat that filter abundant dispersion back, packing gets final product.
Above-mentioned prescription is used for skin and mucous membrane disinfection.
Embodiment 3
Prescription: deionized water 4965g, hydrochloric acid chlorhexidine 5g, sodium Diacetate 5g, OP-1010g, Nonoxynol-9 10g, lauryl alcohol benzoic ether 5g.
Preparation method: under agitation hydrochloric acid chlorhexidine and sodium Diacetate slowly are dissolved in the deionized water, are continuing to add OP-10, Nonoxynol-9 and lauryl alcohol benzoic ether under the condition of stirring then, treat fully to disperse back filtration, packing to get final product.
Above-mentioned prescription is used for skin and mucous membrane disinfection.
Embodiment 4
Prescription: deionized water 4870g, gluconic acid chlorhexidine 10g, sodium Diacetate 50g, OP-1050g, Nonoxynol-9 5g, glycerine 15g.
Preparation method: under agitation gluconic acid chlorhexidine and sodium Diacetate slowly are dissolved in the deionized water, are continuing to add OP-10, Nonoxynol-9 and glycerine under the condition of stirring then, treat fully to disperse back filtration, packing to get final product.
Above-mentioned prescription is used for skin and mucous membrane disinfection.
Embodiment 5
Prescription: deionized water 4920g, chlorhexidine acetate 10g, sodium Diacetate 20g, ONID corrosion inhibitor 50g.
Preparation method: under agitation chlorhexidine acetate and sodium Diacetate slowly are dissolved in the deionized water, are continuing to add the ONID corrosion inhibitor under the condition of stirring then, treat that filter abundant dispersion back, packing gets final product.
Above-mentioned prescription is used for disinfecting of medical device, directly soaks to get final product in 30 minutes.
Embodiment 6
Prescription: deionized water 4865g, ethanol 100g, hydrochloric acid chlorhexidine 10g, sodium Diacetate 25g.
Preparation method: earlier ethanol is mixed with deionized water, under agitation hydrochloric acid chlorhexidine and sodium Diacetate are added then, make its slow dissolving, treat that filter abundant dispersion back, packing gets final product.
Above-mentioned prescription is used for disinfectants such as cleaners and polishes, clothing, ground, metope to be used.
Embodiment 7
Prescription: deionized water 3500g, ethanol 1500g, chlorhexidine acetate 5g, sodium Diacetate 5g, lemon extract 0.1g, OP-105g.
Preparation method: earlier ethanol is mixed with deionized water, under agitation chlorhexidine acetate and sodium Diacetate are added then, make its slow dissolving, under the continuation condition of stirring, add OP-10 and lemon extract, treat fully to disperse back filtration, packing to get final product.
Above-mentioned prescription is used for air sanitizer to be used.
Embodiment 8
Prescription: deionized water 4990g, hydrochloric acid chlorhexidine 5g, sodium Diacetate 5g, carbomer 10g.
Preparation method: under agitation slowly be dissolved in chlorhexidine and sodium Diacetate in the deionized water, treat fully to disperse the back to filter, add carbomer again and stir, regulate in right amount about pH value to 6.5 and can form gel with adding 10% sodium hydrate aqueous solution, packing gets final product then.
That above-mentioned prescription can be used for is mucocutaneous, the sterilization of cleaners and polishes, clothing, ground, metope etc. is used.
Embodiment 9
Prescription: deionized water 4250g, gluconic acid chlorhexidine 250g, sodium Diacetate 500g.
Preparation method: under agitation gluconic acid chlorhexidine and sodium Diacetate slowly are dissolved in the deionized water, treat fully to disperse back filtration, packing to get final product.
That above-mentioned prescription can be used for is mucocutaneous, the sterilization of cleaners and polishes, clothing, ground, metope etc. is used.
Embodiment 10
Prescription: deionized water 4994.95g, hydrochloric acid chlorhexidine 50mg, sodium Diacetate 5g.
Preparation method: under agitation hydrochloric acid chlorhexidine and sodium Diacetate slowly are dissolved in the deionized water, treat fully to disperse back filtration, packing to get final product.
Above-mentioned prescription can be used for the sterilization of clothing, ground, metope etc. to be used.
Embodiment 11
Prescription: chlorhexidine acetate 100g, sodium Diacetate 200g, sodium carboxymethyl starch 80g, starch 200g, talcum powder 420g.
The preparation method: chlorhexidine acetate and sodium Diacetate and sodium carboxymethyl starch, starch, talcum powder are mixed, be pressed into 1000, every 1g.
Above-mentioned tablet can be thrown in 5～10 consumptions by every 1000ml water and use, and is used for disinfecting of mucocutaneous, cleaners and polishes, clothing, ground, metope etc.
Experimental example 1
The killing bacteria contrast experiment
Experimental standard carries out with reference to GB15981-1955 sterilization and evaluation method and the standard of sterilization effect, and to chlorhexidine and pair sodium acetate effect bacteriums 10 minutes, the result who cultivates 48～168 hours was as shown in table 1.
Table 1 killing bacteria experimental result
As can be seen from Table 1, in chlorhexidine, add two sodium acetates and not only can strengthen its bactericidal effect, and can expand its bactericidal range, common bacterial spore, mould etc. are all had good killing effect.
Claims (8)
1. complex type broad-spectrum disinfectant, it is characterized in that, the active component of this disinfectant comprises chlorhexidine and salt and sodium Diacetate, and active component disperses the back to account for 0.001～5% of total amount in described chlorhexidine of weight ratio and salt thereof in solvent, and sodium Diacetate accounts for 0.01～10% of total amount; The salt of described chlorhexidine is meant gluconate or acetate or hydrochloride.
2. complex type broad-spectrum disinfectant according to claim 1 is characterized in that, described solvent is water, ethanol or their mixture.
3. complex type broad-spectrum disinfectant according to claim 1 is characterized in that described chlorhexidine and salt thereof account for 0.005～0.2% of total amount, and sodium Diacetate accounts for 0.02～1% of total amount.
4. complex type broad-spectrum disinfectant according to claim 1 is characterized in that, described disinfectant is a solution.
5. complex type broad-spectrum disinfectant according to claim 1 is characterized in that, described disinfectant is a gel.
6. complex type broad-spectrum disinfectant according to claim 1 is characterized in that, described disinfectant is a tablet.
7. complex type broad-spectrum disinfectant according to claim 1 is characterized in that, described disinfectant is a wet tissue.
8. according to claim 4 or 5 described complex type broad-spectrum disinfectants, it is characterized in that, also contain the composition that one or more are selected from following material in this disinfectant, (1) surfactant, (2) viscosity modifier, (3) detergent, (4) corrosion inhibiter, (5) emollient, (6) aromatic.
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| CN105476869A (en) * | 2015-11-03 | 2016-04-13 | 河北氏氏美卫生用品有限责任公司 | Disinfection wet tissue |
| CN105878115A (en) * | 2016-05-22 | 2016-08-24 | 俞凤鸣 | Disinfectant and environment-friendly wet tissue |
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| CN107434949A (en) * | 2017-09-22 | 2017-12-05 | 苏州振振好新型建材科技有限公司 | A kind of Novel Antibacterial Coatings and its preparation and application process |
| CN109247348A (en) * | 2018-10-08 | 2019-01-22 | 湖北海联技术咨询有限公司 | A kind of Efficient antibacterial medical disinfecting water and preparation method thereof |
| CN111296932A (en) * | 2020-03-12 | 2020-06-19 | 优仕康生（天津）科技发展有限公司 | Infectious disease prevention and control mask with disinfecting and killing effects |
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