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CN103638345B - A kind of medicine for the treatment of insufficiency of lung-QI and preparation method thereof - Google Patents

️Wed Aug 05 2015

A kind of medicine for the treatment of insufficiency of lung-QI and preparation method thereof Download PDF

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CN103638345B

CN103638345B CN201310582075.0A CN201310582075A CN103638345B CN 103638345 B CN103638345 B CN 103638345B CN 201310582075 A CN201310582075 A CN 201310582075A CN 103638345 B CN103638345 B CN 103638345B Authority

China

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gram

radix

grams

rhizoma

dry

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2013-11-20

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CN201310582075.0A

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CN103638345A (en

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蒋学

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2013-11-20

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2013-11-20

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2015-08-05

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2014-03-19 Publication of CN103638345A publication Critical patent/CN103638345A/en

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2015-08-05 Publication of CN103638345B publication Critical patent/CN103638345B/en

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Abstract

The invention discloses a kind of medicine for the treatment of insufficiency of lung-QI and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Radix Pseudostellariae, Rhizoma Alismatis, Placenta Hominis, Radix Ophiopogonis, Bulbus Fritillariae Thunbergii, Gecko, PINGDIMU, Stalactitums, medicine of the present invention has nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough, the function of invigorating the lung and benefiting vital QI, be used for the treatment of insufficiency of lung-QI instant effect, short treating period, have no side effect.

Description

A kind of medicine for the treatment of insufficiency of lung-QI and preparation method thereof

Technical field

The present invention relates to a kind of medicine being used for the treatment of insufficiency of lung-QI and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Insufficiency of lung-QI refers to deficiency and damage of lung-QI, and clinical manifestation is that cough with asthma is unable, deficient QI being not enough to breathe, dynamic then more very, clear and thin sputum, pale white complexion or Guang white, physical fatigue and lassitude of spirit, sound is low timid.Spontaneous perspiration, anemophobia, be easy to flu, pale tongue with white fur, weak pulse is unable.At present, western medicine insufficiency of lung-QI poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating insufficiency of lung-QI in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment insufficiency of lung-QI, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating insufficiency of lung-QI.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Pseudostellariae, Rhizoma Alismatis, Placenta Hominis, Radix Ophiopogonis, Bulbus Fritillariae Thunbergii, Gecko, PINGDIMU, Stalactitum, Radix Polygalae, Radix Asteris, Bulbus Fritillariae Cirrhosae, Radix Glehniae, Semen Persicae, Rhizoma Imperatae, the Rhizoma Pinelliae, Fructus Corni, Folium Mori, Folium Eriobotryae, Rhizoma Polygonati, Semen Sesami Nigrum, Radix Platycodonis, Rhizoma Dioscoreae, Radix Adenophorae, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Momordicae, Rhizoma Cimicifugae, Cortex Lycii medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating insufficiency of lung-QI.Radix Pseudostellariae is wherein selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Placenta Hominis to be because its property sweet-salty, temperature, enters lung, liver, kidney channel, has QI invigorating, nourish blood, and the function of benefit essence, controls deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, and women's vim and vigour are not enough, infertile or newborn few.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Bulbus Fritillariae Thunbergii is selected to be that be slightly cold, return lung, heart channel, have heat clearing away eliminating stagnation, the function of preventing phlegm from forming and stopping coughing, controls wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore, and ambition is gloomy because its nature and flavor are bitter.Select Gecko to be because its nature and flavor are salty, flat, enter lung, kidney channel, have invigorating the lung and the kidney, the function of Dingchuan antitussive, controls asthenia, and consumptive lung disease is breathed heavily and coughed, and spitting of blood, quenches one's thirst, sexual impotence.PINGDIMU is selected to be that micro-hardship, returns lung, Liver Channel, have expelling phlegm for arresting cough, promoting diuresis to eliminate damp pathogen, the function of blood circulation promoting and blood stasis dispelling, controls new chronic cough and coughs, sputum mixed with blood, jaundice due to damp-heat, traumatic injury because its nature and flavor are pungent.Stalactitum is selected to be that temperature, enter lung, kidney channel, have warming the lung gas, kidney-Yang invigorating, the function of lower milk, controls asthenia and breath with cough, cough of cold type, sexual impotence, cold arthralgia of loins and legs, galactostasis because its nature and flavor are sweet.Select Radix Polygalae to be because its nature and flavor toil, temperature, enter the heart, kidney channel, have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the function of resolving depression, controls palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, and carbuncle skin ulcer swells.Select Radix Asteris to be because its nature and flavor are bitter, temperature, enter lung meridian, have warming the lung, the therapeutic method to keep the adverse QI flowing downwards, water expectorant, the function of cough-relieving, controls wind and cold, and cough, Zhichuan, asthenia coughs vomiting bloody pus.Bulbus Fritillariae Cirrhosae is selected to be because its property bitter but sweet flavor, cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select Radix Glehniae to be that enter lung, spleen channel, have nourishing YIN and clearing away lung-heat, the function of expelling phlegm for arresting cough, controls lung-heat type cough, chronic consumptive disease chronic cough because its nature and flavor sweetness and bitterness is light, cool, the moon hinders dry pharynx, thirsty.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Rhizoma Imperatae to be sweet because of its nature and flavor, cold, enter lung, stomach, small intestine meridian, have removing heat from blood, hemostasis, heat clearing away, the function of diuresis, controls calentura excessive thirst, spits blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Fructus Corni is selected to be that tepor, has invigorating the liver and kidney, and the function of arresting seminal emission gas, controls sexual impotence, and seminal emission, deficiency of the liver cold and heat, the heart shakes scattered pulse because its nature and flavor acid.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Select Folium Eriobotryae to be because its nature and flavor are bitter, cool, attach to the lung and stomach meridians, have lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm, control lung-heat phlegmatic cough, hemoptysis, epistaxis, gastric heat is vomitted the sound of vomiting.Select Rhizoma Polygonati to be because its nature and flavor are sweet flat, enter spleen, lung, kidney channel, have invigorating the spleen and replenishing QI, profit cardiopulmonary, the function of bone and muscle strengthening, controls deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill the empty lack of appetite of body, and muscles and bones is weak, rheumatalgia, wind favus disease.Select Semen Sesami Nigrum, different name Semen Lini, its nature and flavor are sweet, flat, return liver, kidney, large intestine channel, have invigorating the liver and kidney, benefiting essence-blood, the function that intestine moistening is dry, control and feel dizzy, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, have spleen invigorating, tonifying the lung, reinforce the kidney, the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Radix Adenophorae to be that be slightly cold, attach to the lung and stomach meridians, have nourishing YIN and clearing away lung-heat, reduce phlegm, the function of QI invigorating, controls lung-heat type cough, deficiency of YIN phthisical cough because its nature and flavor are sweet, dry cough expectorant sticks, deficiency of both vital energy and Yin, restlessness and fever with thirst.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizzy, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select Fructus Momordicae to be because its nature and flavor are sweet, enter lung, spleen two warp, have the function of clearing away heat and moistening the bowels, control pertussis, phlegm-fire cough, the dry constipation of blood.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Optionally Cortex Lycii is because its nature and flavor are sweet, cold, and enter lung, liver, kidney channel, have heat clearing away, the function of removing heat from blood, control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Pseudostellariae 10-20 gram of Rhizoma Alismatis 5-15 gram of Placenta Hominis 10-20 gram

Radix Ophiopogonis 10-20 gram of Bulbus Fritillariae Thunbergii 5-15 gram of Gecko 10-20 gram

PINGDIMU 10-20 gram of Stalactitum 5-15 gram Radix Polygalae 10-20 gram

Radix Asteris 10-20 gram of Bulbus Fritillariae Cirrhosae 5-15 gram of Radix Glehniae 10-20 gram

Semen Persicae 10-20 gram of Rhizoma Imperatae 5-15 gram of Rhizoma Pinelliae 10-20 gram

Fructus Corni 10-20 gram of Folium Mori 5-15 gram of Folium Eriobotryae 10-20 gram

Rhizoma Polygonati 15-25 gram of Semen Sesami Nigrum 15-25 gram of Radix Platycodonis 25-35 gram

Rhizoma Dioscoreae 15-25 gram of Radix Adenophorae 15-25 gram of Radix Rehmanniae Preparata 25-35 gram

Fructus Ligustri Lucidi 15-25 gram of Fructus Momordicae 15-25 gram liter fiber crops 25-35 gram

Cortex Lycii 15-25 gram

Preferable amount is

Radix Pseudostellariae 15 grams of Rhizoma Alismatis 10 grams of Placenta Hominiss 15 grams

Radix Ophiopogonis 15 grams of Bulbus Fritillariae Thunbergiis 10 grams of Geckos 15 grams

PINGDIMU 15 grams of Stalactitums 10 grams of Radix Polygalaes 15 grams

Radix Asteris 15 grams of Bulbus Fritillariae Cirrhosaes 10 grams of Radix Glehniaes 15 grams

Semen Persicae 15 grams of Rhizoma Imperataes 10 grams of Rhizoma Pinelliaes 15 grams

Fructus Corni 15 grams of Folium Mori 10 grams of Folium Eriobotryaes 15 grams

Rhizoma Polygonati 20 grams of Semen Sesami Nigrums 20 grams of Radix Platycodoniss 30 grams

Rhizoma Dioscoreae 20 grams of Radix Adenophoraes 20 grams of Radix Rehmanniae Preparata 30 grams

Fructus Ligustri Lucidi 20 grams of Fructus Momordicae 20 gram liter fiber crops 30 grams

Cortex Lycii 20 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Pseudostellariae: extract fibrous root, dry;

2, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, moistening is even to inside and outside humidity, and section, dries;

3, Placenta Hominis: with fresh Placenta Hominis, anyhow cut open blood vessel, washes drift totally repeatedly with water;

4, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

5, Bulbus Fritillariae Thunbergii: removing impurity, size stepping, cleans, runs through, cut sheet or smash, dry;

6, Gecko: removing bamboo chip, clips cephalopodium and squama, dices;

7, PINGDIMU: removing impurity, cleans, slightly moistens, cutting, dry;

8, Stalactitum: wash, is broken into fritter;

9, Radix Polygalae: pick decontamination, cutting, sieve dedust bits;

10, Radix Asteris: pick decontamination, removes residual stem, and clean, slightly moistening, is cut into segment, dries;

11, Bulbus Fritillariae Cirrhosae: pick decontamination, slightly steeps with water, pulls out, and moistening peels off the heart, dries;

12, Radix Glehniae: pick decontamination, removing stem foot, slightly washes with water, pulls out, slightly moisten, cutting, dry;

13, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

14, Rhizoma Imperatae: pick clean impurity, clean, micro-profit, cutting, dries, clean chip of winnowing with a dustpan;

15, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

16, Fructus Corni: clean, except removal core and impurity, dry;

17, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;

18, Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;

19, Rhizoma Polygonati: clean earth, slightly profit, section, dries;

20, Semen Sesami Nigrum: get crude drug, removing impurity, sieve removes chip;

21, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

22, Rhizoma Dioscoreae: pick clean impurity, be soaked in water to Rhizoma Dioscoreae central part and soften, pull out and slightly dry in the air, section is dried or is dried;

23, Radix Adenophorae: removing fibrous root, cleans, scrapes off rough bark, dry;

24, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

25, Fructus Ligustri Lucidi: pick decontamination, cleans, dries;

26, Fructus Momordicae: pluck when fruit is ripe between the 9-10 month, put on floor, make its after-ripening, about 8-10 days peel turns yellow by green grass or young crops, dries a heatable brick bed, through 5-6 days, become the sound dry fruit of kowtowing, then bristle with fire;

27, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

28, Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry.

Two, prepare

1, the Radix Pseudostellariae of described weight, Rhizoma Alismatis, Placenta Hominis, Radix Ophiopogonis, Bulbus Fritillariae Thunbergii, Gecko, PINGDIMU, Stalactitum, Radix Polygalae, Radix Asteris, Bulbus Fritillariae Cirrhosae, Radix Glehniae, Semen Persicae, Rhizoma Imperatae, the Rhizoma Pinelliae, Fructus Corni, Folium Mori, Folium Eriobotryae, Rhizoma Polygonati, Semen Sesami Nigrum, Radix Platycodonis, Rhizoma Dioscoreae, Radix Adenophorae, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Momordicae, Rhizoma Cimicifugae, Cortex Lycii medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 25 minutes, use slow fire boiling again 35 minutes, filter first time decoction liquor.

2, add water the medicinal residues of filtration 4 times amount, and intense fire boils 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.

3, merge secondary decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, is divided into 3 doses to take.

Medicine of the present invention has nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough, and the function of invigorating the lung and benefiting vital QI, is used for the treatment of insufficiency of lung-QI, short treating period, instant effect, has no side effect.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy insufficiency of lung-QI of the present invention

1, physical data

Accept Patients with Lung-Qi Deficiency Syndrome totally 240 examples for medical treatment.

2, diagnostic criteria

The common five kinds of performances of insufficiency of lung-QI:

(1) weak breath is weak, slightly works, and pant, and breathes tachypnea;

(2) resistance against diseases is low, easily infects exopathogen, is easy to flu, has the disease of fear of cold, snivel more;

(3) meet cold easily to show effect sinusitis;

(4) common skin drying, shrinkage, pruritus are especially outstanding when the autumn and winter are dry;

(5) often can cause insufficiency of kidney-YANG, water liquid is run unfavorable, occur frequent micturition number, the heeltap not to the utmost.

The clinical manifestation of syndrome of deficiency of lung qi is that cough with asthma is breathed hard, and sound is low timid, spontaneous perspiration with aversion to wind, susceptible exopathogen, shortness of breath and fatigue, pallor Mental fatigue, pale tongue with white fur, weak pulse etc.Take charge of breathing and sound due to all gas of lung master, have defeated cloth precise and tiny in whole body, the effect of regulating fluid apssage.Thus on pathology, insufficiency of lung-QI, pectoral qi is lost few in the heart first, breathes mistake department; Second defend QI-insufficiency, weakened defensive QI, easily attack by exopathogen; Three is that insufficiency of lung-QI less can not regulating fluid apssage, spreading vital essence and cause the imbalance of water liquid, and the internal organs whole body is lost and supported.So the dialectical main points of insufficiency of lung-QI roughly have following several respects: low voice of 1. coughing is unable, dyspnea and shortness of breath, the timid lazyness speech of sound, abundant expectoration is rare clearly.2. complexion is not flourish, fear of cold spontaneous perspiration, and fatigue and weak, easily suffers from diseases caused by exogenous pathogenic factor, or deficiency of spleen-QI causes large intestine transmit unable and cause constipation, though have awareness of defecation and accompany sweating to breathe hard under difficulty in defecation.3. except above-mentioned lung meridian symptom and general manifestation, common pale tongue, white and thin fur, deficient pulse or thin and delicate.

3, Therapeutic Method

Select the invention described above medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: insufficiency of lung-QI transference cure, observe half a year without bounce-back person;

Take a turn for the better: insufficiency of lung-QI symptom is obviously improved, and body constitution progressively strengthens;

Invalid: insufficiency of lung-QI symptom, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy Patients with Lung-Qi Deficiency Syndrome 240 example of the present invention, effective 231 examples of result, obvious effective rate is 96.25%, and take a turn for the better 5 examples, and improvement rate is 2.08%, and invalid 4 examples, total effective rate is 98.33%.

Claims (3)

1. treat a medicine for insufficiency of lung-QI, it is characterized in that: it is made up of the crude drug in following weight range: