CN103666964B - A kind of kidney healthful tonic wine and preparation method thereof - Google Patents

一种益肾补酒，由枸杞子，菟丝子，覆盆子，车前子，五味子，白酒，蔗糖，经过前处理、配料、水提、浓缩、醇沉、配液、灌封制得。本发明具有补肾益肾，滋阴壮阳，益精养血，增强免疫力，抗疲填精补髓，益肾扶阳、增强免疫力的功效。与传统药酒相比，益肾补酒具有药效强、见效快、疗效高、且成本低等优点，具有很好的开发应用前景。The kidney-reinforcing wine is prepared from wolfberry fruit, dodder fruit, raspberry, plantago seed, schisandra fruit, white wine and sucrose through pretreatment, batching, water extraction, concentration, alcohol precipitation, liquid preparation and potting. The invention has the functions of invigorating kidney and kidney, nourishing yin and strengthening yang, nourishing essence and nourishing blood, enhancing immunity, resisting fatigue, filling essence and replenishing marrow, nourishing kidney and supporting yang, and enhancing immunity. Compared with traditional medicinal wine, Yishen Tonic Wine has the advantages of strong drug effect, quick effect, high curative effect, and low cost, and has good development and application prospects.

一种益肾补酒及其制备方法A kind of kidney-reinforcing wine and preparation method thereof

技术领域technical field

本发明涉及具有补肾益肾的中药保健酒，具体地说是一种益肾补酒及其制备方法。The invention relates to traditional Chinese medicine health-care wine capable of tonifying the kidney and invigorating the kidney, in particular to a kidney-tonifying wine and a preparation method thereof.

背景技术Background technique

随着经济的发展和人们生活水平的提高，人们更加注重自己的身体健康和生命质量。中医理论中的“肾”是人体的一个重要系统。它包括泌尿系统的肾、人的生殖、免疫、内分泌等系统。肾脏乃先天精储之地，为生命之根本，主宰生长发育。肾脏衰竭则出现气短神疲、腰膝酸软和早衰等症状。为解决上述问题，强身健体，医药研发人员正不断研制开发各种具有特色的补肾中成药或保健酒。With the development of the economy and the improvement of people's living standards, people pay more attention to their health and quality of life. The "kidney" in TCM theory is an important system of the human body. It includes the kidneys of the urinary system, human reproductive, immune, endocrine and other systems. The kidney is the place where the innate essence is stored, the foundation of life, and governs growth and development. Symptoms of kidney failure include shortness of breath, fatigue, soreness of the waist and knees, and premature aging. In order to solve the above problems and keep fit, medical research and development personnel are constantly developing various Chinese patent medicines for tonifying the kidney or health-care wine with characteristics.

发明内容Contents of the invention

本发明要解决的问题是提供一种具有填精补髓、益肾扶阳的益肾补酒。The problem to be solved by the present invention is to provide a kidney-reinforcing wine with the functions of nourishing essence and marrow, nourishing kidney and supporting yang.

为解决上述技术问题，本发明采用的技术方案是：一种益肾补酒，其特征在于，每升药酒是由下述重量比原料制成的：In order to solve the above-mentioned technical problems, the technical solution adopted in the present invention is: a kind of kidney-reinforcing wine, which is characterized in that every liter of medicinal wine is made of the following raw materials in weight ratio:

优选的，每升药酒是由下述重量比原料制成的：Preferably, every liter of medicinal wine is made from the following weight ratio raw materials:

优选的，每升药酒是由下述重量比原料制成的：Preferably, every liter of medicinal wine is made from the following weight ratio raw materials:

进一步，每3760升药酒是由下述重量比原料制成的：Further, every 3760 liters of medicated wine is made from the following weight ratio raw materials:

该配方中，车前子为盐制，五味子为酒制。白酒为65°±1°。In this formula, the psyllium is made from salt, and the schisandra is made from wine. Liquor is 65°±1°.

本发明中，枸杞子、菟丝子、覆盆子补益肾精，以实现精足髓充、肾气自固的功效，佐以五味子、车前子益肾固精，以加强药材的疗效。该方制成的补酒用于身体虚弱，肾亏阳痿，梦遗滑精，尿液浑浊。In the present invention, Fructus Lycium barbarum, Fructus Cuscuta, and Raspberry nourish the essence of the kidney to realize the effect of replenishing the essence and marrow and self-consolidating the kidney qi, together with schisandra chinensis and psyllium to strengthen the kidney and strengthen the essence to strengthen the curative effect of the medicinal materials. The tonic wine made from this prescription is used for physical weakness, impotence due to kidney deficiency, nocturnal emission, and cloudy urine.

本发明的益肾补酒适用于口服，一次30ml，一日1次。The kidney-tonifying wine of the present invention is suitable for oral administration, 30ml at a time, once a day.

本发明的另一目的在于提供一种制备益肾补酒的方法，包括以下步骤：Another object of the present invention is to provide a method for preparing kidney tonic wine, comprising the following steps:

（1）对上述原料药材进行前处理，进行洗切、炮制；(1) Pre-treat, wash, cut and process the above-mentioned raw medicinal materials;

（2）将枸杞子、菟丝子、覆盆子、车前子、五味子按上述处方量的进行配料；(2) Ingredients of medlar, dodder, raspberry, plantain, and schisandra according to the above prescription amount;

（3）将配好的药材进行水提、浓缩、醇沉、静置；(3) Carry out water extraction, concentration, alcohol precipitation and standing of the prepared medicinal materials;

（4）将蔗糖加沸水溶解制成单糖浆，并用蒸馏水调整至适量；(4) Dissolve sucrose with boiling water to make simple syrup, and adjust to an appropriate amount with distilled water;

（5）将步骤（3）中静置后得到的上清液与步骤（4）制的单糖浆进行真空配液；(5) Vacuum dosing the supernatant obtained after standing in step (3) and the simple syrup prepared in step (4);

（6）静置20天以上，灌封。(6) Let it stand for more than 20 days, and then seal it.

其中，步骤（3）中的浓缩操作是在真空度达到-0.08mPa条件下，将药液浓缩至70～75℃时密度1.10～1.14g/cm3。Wherein, the concentrating operation in step (3) is to concentrate the medicinal solution to a density of 1.10-1.14 g/cm3 at 70-75° C. under the condition that the degree of vacuum reaches -0.08 mPa.

步骤（3）中的醇沉、静置操作是将水提浓缩液放冷，加入处方量的白酒，边加边搅拌，加完后搅拌30分钟，加盖密封，静置一天以上。The alcohol precipitation and standing operation in step (3) is to cool the water-extracted concentrated solution, add the prescribed amount of white wine, stir while adding, and stir for 30 minutes after adding, cover and seal, and let stand for more than one day.

步骤（5）中真空配液的真空度不低于-0.08mPa，配液应在4小时内完成。The vacuum degree of vacuum dosing in step (5) is not lower than -0.08mPa, and the dosing should be completed within 4 hours.

本发明采用多种益肾药材进行合理配制，通过水提、浓缩、醇沉、调配等多道工序工艺加制，辅料为白酒，药借酒势，酒助药力，使该产品的填精补髓、益肾扶阳的功效达到极致，在治疗身体虚弱、肾亏阳痿，梦遗滑精、尿液混浊等方面有显著效果。The present invention adopts a variety of kidney-invigorating medicinal materials for reasonable preparation, and is processed through multiple processes such as water extraction, concentration, alcohol precipitation, and deployment. The auxiliary material is white wine. The efficacy of the marrow, nourishing the kidney and supporting the yang reaches the extreme, and it has a significant effect in treating physical weakness, impotence due to kidney deficiency, nocturnal emission, and cloudy urine.

具体实施方式Detailed ways

实施例1：Example 1:

枸杞子432.0kg，菟丝子336.0kg，覆盆子240.0kg，车前子（盐制）96.0kg，五味子（酒制）48.0kg，白酒（65°）2280kg，蔗糖294.5kg。Lycium barbarum 432.0kg, dodder 336.0kg, raspberry 240.0kg, plantain seed (salt) 96.0kg, schisandra (wine) 48.0kg, liquor (65°) 2280kg, sucrose 294.5kg.

1.前处理：1. Pre-processing:

对上述原料药材进行前处理，进行洗切、炮制；Carry out pretreatment to above-mentioned raw medicinal materials, carry out washing cutting, processing;

2.水提操作：2. Water extraction operation:

将枸杞子、菟丝子、覆盆子、车前子（盐制）、五味子（酒制）分成六份，每份192kg，将一份水提的处方量药材投入多功能提取罐内，加水煎煮两次，第一次加入药材10倍量水（1920kg），盖紧提取罐的盖,以料液沸腾时开始计时提取2小时,提取完毕应先关闭加热蒸汽阀门，再将提取液经输液泵过滤后泵入储液罐;第二次加入药材6倍量水（1152kg），重复以上操作，提取1.5小时,合并两次提取液。Divide wolfberry fruit, dodder fruit, raspberry, plantain seed (salt system) and schisandra fruit (wine system) into six portions, each portion 192kg, put a prescription amount of medicinal materials extracted by water into a multi-functional extraction tank, add water and boil for two For the first time, add 10 times the amount of water (1920kg) of the medicinal material, cover the lid of the extraction tank tightly, and start counting the extraction for 2 hours when the material liquid boils. After the extraction, the heating steam valve should be closed first, and then the extraction liquid should be filtered through the infusion pump Then pump it into the liquid storage tank; add 6 times the amount of water (1152kg) of the medicinal material for the second time, repeat the above operation, extract for 1.5 hours, and combine the two extracts.

过程中，加热蒸汽压力大小应以维持药液微沸为度,并随时观察加热蒸汽压力表控制气量和提取罐的工作情况,防止药液外溢。During the process, the pressure of the heating steam should be adjusted to maintain the slight boiling of the liquid medicine, and the pressure gauge of the heating steam to control the gas volume and the working conditions of the extraction tank should be observed at any time to prevent the liquid medicine from overflowing.

使用另一提取罐，按照同样的方法进行另一份水提药材的提取，同样，将合并的两次提取液。Using another extraction tank, carry out the extraction of another part of water extraction medicinal material according to the same method, and similarly, combine the two extracts.

3.浓缩操作：3. Concentration operation:

合并两份水提药材的提取液，置于储液罐。使浓缩罐真空度达到-0.08mPa,开吸液阀将储液罐内的提取液陆续进入单效浓缩器进行浓缩操作。将药液浓缩至70～75℃时密度1.10～1.14（小于210kg），关闭蒸汽，开启冷却水，将浓缩液转入醇沉罐，移交醇沉工序。Combine the extracts of the two water-extracted medicinal materials and place them in a liquid storage tank. Make the vacuum degree of the concentration tank reach -0.08mPa, open the suction valve, and the extract in the liquid storage tank enters the single-effect concentrator successively for concentration operation. Concentrate the medicinal solution to a density of 1.10-1.14 (less than 210kg) at 70-75°C, turn off the steam, turn on the cooling water, transfer the concentrated solution to the alcohol precipitation tank, and hand over the alcohol precipitation process.

4.醇沉操作：4. Alcohol precipitation operation:

将水提浓缩液泵入醇沉罐后，放冷，加入处方量白酒，边加边搅拌，加完后搅拌30分钟，加盖密封，静置一天以上，备用。After pumping the water-extraction concentrate into the alcohol precipitation tank, let it cool, add the prescribed amount of white wine, stir while adding, and stir for 30 minutes after adding, cover and seal, let stand for more than one day, and set aside.

其他四份按上述方法进行水提、浓缩、醇沉的操作。将醇沉、静置后的药液取上清液转入配液工序。The other four were subjected to water extraction, concentration, and alcohol precipitation as described above. The supernatant of the medicinal liquid after alcohol precipitation and standing is transferred to the liquid preparation process.

5.配液操作：5. Dosing operation:

化糖锅中加入定量纯化水,打开加热蒸汽(压力不得超过0.2mPa),待水煮沸后加入处方量蔗糖,边加边用搅拌铲搅拌,使蔗糖全部溶解,再加热至沸腾。将化糖锅内单糖浆泵入定容罐内,在化糖锅加入纯水适量,用搅拌铲搅拌,至挂壁的糖浆全部溶解后泵入定容罐到定量。Add quantitative purified water into the sugar pot, turn on the heating steam (the pressure should not exceed 0.2mPa), add the prescribed amount of sucrose after the water is boiled, stir with a stirring shovel while adding, so that all the sucrose is dissolved, and then heat to boiling. Pump the simple syrup in the sugar pot into the constant volume tank, add an appropriate amount of pure water into the sugar pot, and stir with a stirring shovel until all the syrup hanging on the wall is dissolved, then pump it into the constant volume tank to a certain amount.

将单糖浆通过泵打入装有药液的配液罐内,打开真空阀门,真空度不低于-0.08mPa时,关闭真空阀,开启真空阀,反复4次,混匀,配液应在4小时内完成。Put the simple syrup into the liquid preparation tank with the liquid medicine through the pump, open the vacuum valve, when the vacuum degree is not lower than -0.08mPa, close the vacuum valve, open the vacuum valve, repeat 4 times, mix well, the liquid preparation should be at Complete within 4 hours.

配液完成后，静置20天以上，灌封，制得3760升益肾补酒。After the dosing was completed, it was left to stand for more than 20 days, and then potted to obtain 3760 liters of kidney-reinforcing wine.

本发明的用法和用量：口服，一次30ml，一日1次。Usage and dosage of the present invention: take orally, 30ml each time, once a day.

实施例2：Example 2:

枸杞子430kg，菟丝子335kg，覆盆子236kg，车前子（盐制）95kg，五味子（酒制）46kg，白酒（65°）2350kg，蔗糖280kg。Lycium barbarum 430kg, dodder 335kg, raspberry 236kg, psyllium (salt) 95kg, schisandra (wine) 46kg, liquor (65°) 2350kg, sucrose 280kg.

其制备方法同实施例1。Its preparation method is with embodiment 1.

实施例3：Example 3:

枸杞子440kg，菟丝子342kg，覆盆子250kg，车前子（盐制）92kg，五味子（酒制）53kg，白酒（65°）2400kg，蔗糖342kg。Lycium barbarum 440kg, dodder 342kg, raspberry 250kg, psyllium (salt) 92kg, schisandra (wine) 53kg, liquor (65°) 2400kg, sucrose 342kg.

其制备方法同实施例1。Its preparation method is with embodiment 1.

实施例4：Example 4:

枸杞子428kg，菟丝子330kg，覆盆子240kg，车前子（盐制）98kg，五味子（酒制）42kg，白酒（65°）2260kg，蔗糖275kg。Lycium barbarum 428kg, dodder 330kg, raspberry 240kg, psyllium (salt) 98kg, schisandra (wine) 42kg, liquor (65°) 2260kg, sucrose 275kg.

其制备方法同实施例1。Its preparation method is with embodiment 1.

实验例1：Experimental example 1:

临床研究协作组对本发明的疗效及保健作用进行了验证，具体实施方案如下：The clinical research cooperation group has verified the curative effect of the present invention and health-care effect, and specific implementation scheme is as follows:

一、病例选择1. Case selection

观察对象男女兼顾，年龄以中老年为主，有胃肠疾患者，有严重心、肺、肝肾、脑功能损害者不作观察对象；服用益肾补酒前两周及服用期间，停用其他保健饮料及治疗药。Observation objects are both male and female, mainly middle-aged and elderly people, patients with gastrointestinal diseases, and those with severe heart, lung, liver, kidney, and brain function damage are not included as observation objects; two weeks before and during the period of taking Yishenbujiu, other Health drink and medicine.

被观察患者症状：Observed patient symptoms:

1、肾阳虚：腰膝酸软、畏寒肢冷，遗精、阳萎、多尿或失禁，大便清稀伴有完谷不化或黎明泄泻，面色白，舌质淡，伴有齿痕，苔白，脉沉迟。1. Deficiency of kidney yang: soreness of the waist and knees, aversion to cold and cold limbs, nocturnal emission, impotence, polyuria or incontinence, loose stool accompanied by unmelted or dawn diarrhea, pale complexion, pale tongue with tooth marks , white fur, deep and slow pulse.

2、肾气虚：腰膝酸软，小便频数而清，滑精，早泄，面色淡白，舌质淡，苔薄白，脉细弱。2. Kidney qi deficiency: sore waist and knees, frequent and clear urination, slippery semen, premature ejaculation, pale complexion, pale tongue, thin white fur, thready and weak pulse.

3、肝血虚：面色无华，眩晕、夜寐多梦，眼睛干涩，视物模糊或雀盲，肢体麻木或筋脉拘急，爪甲不荣，月经量少或闭经。舌淡，脉细。3. Deficiency of liver blood: dull complexion, dizziness, night sleep and dreaminess, dry eyes, blurred vision or blindness, numbness of limbs or tense tendons, unprosperous nails, menstrual flow or amenorrhea. Pale tongue, thready pulse.

临床观察共30例。男性22例，女性8例。年龄21～30岁3例，31～40岁8例，41～50岁6例，51～60岁9例，61～70岁3例，71岁以上1例。年龄最大72岁，最小23岁。中医辨证分型：肾阳虚20例，肾气虚5例，肝血虚5例。A total of 30 cases were observed clinically. There were 22 males and 8 females. Three cases were aged 21-30 years, 8 cases were 31-40 years old, 6 cases were 41-50 years old, 9 cases were 51-60 years old, 3 cases were 61-70 years old, and 1 case was over 71 years old. The oldest is 72 years old and the youngest is 23 years old. TCM syndrome differentiation: 20 cases of kidney yang deficiency, 5 cases of kidney qi deficiency, and 5 cases of liver blood deficiency.

二、观察及治疗方法2. Observation and treatment

（1）观察项目及方法(1) Observation items and methods

饮用益肾补酒前后，注意观察症状舌脉变化。每10天作一次对比判定记录。肝功能、肾功能治疗前后各作一次检验。注意饮用本品有无不良反应，采用自身对照，对服用前后的系统观察结果进行对比。Before and after drinking Yishenbujiu, pay attention to observe the changes of symptoms, tongue and pulse. Make a comparative judgment record every 10 days. Liver function and renal function were tested before and after treatment. Pay attention to whether there are any adverse reactions after drinking this product, and use self-control to compare the system observation results before and after taking this product.

（2）治疗方法(2) Treatment method

口服，一次30ml，一日1次，30天为一疗程。Orally, 30ml each time, once a day, 30 days as a course of treatment.

（3）观察治疗结果(3) Observe the treatment results

A.疗效判断标准A. Efficacy Judgment Criteria

临床痊愈：治疗后全部症状消失。Clinical recovery: all symptoms disappeared after treatment.

显效：治疗后症状得到显著改善。Significantly effective: the symptoms were significantly improved after treatment.

有效：治疗后症状有减退。Effective: Symptoms subside after treatment.

无效：治疗后无效果。Invalid: no effect after treatment.

B.结果B. Results

服用益肾补酒一个疗程后的治疗效果如下：After taking Yishenbujiu for a course of treatment, the therapeutic effect is as follows:

治疗30天后，按以上疗效判断标准统计30例中，显效20例，占66.67％；有效9例，占30％；无效1例，占3.33％；总有效率96.67％。After 30 days of treatment, among the 30 cases according to the above curative effect judging criteria, 20 cases were markedly effective, accounting for 66.67%; 9 cases were effective, accounting for 30%; 1 case was ineffective, accounting for 3.33%; the total effective rate was 96.67%.