CN105250075A - Wound healing degree monitoring system and method - Google Patents
- ️Wed Jan 20 2016
CN105250075A - Wound healing degree monitoring system and method - Google Patents
Wound healing degree monitoring system and method Download PDFInfo
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Publication number
- CN105250075A CN105250075A CN201510581442.4A CN201510581442A CN105250075A CN 105250075 A CN105250075 A CN 105250075A CN 201510581442 A CN201510581442 A CN 201510581442A CN 105250075 A CN105250075 A CN 105250075A Authority
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- wave length
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- wound
- adhesive layer
- photodiode Prior art date
- 2015-09-12 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00906—Plasters containing means for transcutaneous or transdermal drugs application
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0094—Plasters containing means for sensing physical parameters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a wound healing degree monitoring system and method; the method comprises the following steps: generating light of first wavelength; using a fiber coupler to send the light of the first wavelength to a first multimode fiber of an intelligent sensor; when receiving the first wavelength light, the first wavelength light irradiates a photodiode so as to generate a photoelectric current; calculating a first wavelength light absorptivity by a matrix metalloprotease induction film according to the photoelectric current generated by the first wavelength light irradiating on the photodiode, and determining active degree of the matrix metalloprotease induction film on the present wound according to a preset corresponding relation between the active degree of the matrix metalloprotease induction film and the absorptivity; determining the wound healing degree according to a preset corresponding relation between the active degree of the matrix metalloprotease induction film and the wound healing degree. The system and method can monitor the wound healing degree, and can remind the patient to change fresh dressing according to the healing degree, thus better treating the wound.
Description
Technical field
The present invention relates to wound first-aid equipment, particularly relate to a kind of wound healing degree monitoring system and method.
Background technology
Binder is in order to material that is fixing and protection wound.Common binder has polytype, and the simplest one is single canopy band, is made up of gauze or cotton, is applicable to extremity, afterbody, head and thorax abdomen.Another kind is multiple binder, can make various shape according to body part and shape, and material is double-layer cloth, the Cotton Gossypii of different-thickness can be pressed from both sides between double-layer cloth, periphery has cloth, so that knotting is fixing, as eye bandage, back of the body waist binder, shirtfront binder, abdomen binder etc.
But above-mentioned binder is only only applicable to wrap up anastalsis, cannot monitor wound, doctor or patient cannot understand the healing of wound by binder.Further, described binder cannot remind patient to change dressings in time according to the healing of wound.
Summary of the invention
Main purpose of the present invention is to provide a kind of wound healing degree monitoring system, is intended to solve common binder and cannot monitors the healing of wound and remind the defect of changing dressing for patient according to healing.
For achieving the above object, the invention provides a kind of wound healing degree monitoring system, this system comprises: monitoring equipment, binder body and the intelligence sensor be arranged on binder body, wherein, described monitoring equipment comprises photodiode, the first light source, fiber coupler and processor, described photodiode is connected with described processor, and described first light source is connected with described fiber coupler;
Described intelligence sensor comprises the first multimode fibre, the second multimode fibre and single-mode fiber, described single-mode fiber between described first multimode fibre and described second multimode fibre and formed straight line connect, described single-mode fiber surface-coated has one deck matrix metalloproteinase sense film, when described binder body is pasted on wound, described intelligence sensor is positioned on wound;
Described fiber coupler is connected with described first multimode fibre, and described second multimode fibre is connected with described photodiode;
Described first light source, for generation of the light of first wave length, and sends to described fiber coupler by the light of described first wave length;
Described fiber coupler, for giving described first multimode fibre by the optical transport of described first wave length, the light of described first wave length is through described single-mode fiber extremely described second multimode fibre;
Described photodiode, for receiving the light of first wave length from the second multimode fibre, and photoelectric current when described photodiode is penetrated in the illumination producing first wave length;
Described processor, the photoelectric current produced for penetrating photodiode according to the illumination of first wave length calculates described matrix metalloproteinase sense film to the absorbance of the light of first wave length, and according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and absorbance, determine the level of activity of the matrix metalloproteinase sense film of current wound; And
Described processor, also for according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and the healing of wound, determines the healing of current wound.
Preferably, described matrix metalloproteinase sense film is mapped to the rate of change of the photoelectric current that photodiode produces to the illumination that the absorbance of the light of first wave length is first wave length.
Preferably, described monitoring equipment also comprises secondary light source, this secondary light source is connected with described fiber coupler, this secondary light source is for generation of the light of second wave length, this fiber coupler is also for accumulating a branch of combined light by the light of first wave length and the light of second wave length, and being transmitted into the first multimode fibre, described combined light is through described single-mode fiber extremely described second multimode fibre.
Preferably, described photodiode, also for receiving the light of second wave length in described combined light from the second multimode fibre, and the photoelectric current of the illumination producing second wave length when penetrating photodiode, if when photoelectric current when photodiode is penetrated in the illumination of this second wave length is not in preset range, the transmission path of the light of first wave length and the light of second wave length is corrected, until photoelectric current when photodiode is penetrated in the illumination of second wave length is in preset range by described fiber coupler.
Preferably, described in comprise one deck and make gel by cold water fish glue with containing the phosphate buffer of a certain amount of glutaraldehyde, this gel does not have the copper chlorophyllin of biocompatible to dye with a kind of.
Preferably, described binder body comprises cover layer, medicine layer and adhesive layer, and described cover layer and medicine layer are pasted, and described medicine layer and adhesive layer are pasted, wherein:
Described medicine layer is provided with for pasting bonding strip on described adhesive layer and multiple salient point comprising epidermal growth factor, described salient point is arranged at the surface that described medicine layer and adhesive layer are pasted, the bonding strip of described medicine layer is arranged at the edge on the surface that described medicine layer and adhesive layer are pasted, and described medicine layer is a kind of adhesive structure that can tear from adhesive layer; And
Described adhesive layer is provided with multiple mesh and the bonding strip for pasting edge of wound, the bonding strip of described adhesive layer is arranged at the edge on described adhesive layer surface, when described adhesive layer and medicine layer are pasted, described salient point is embedded in described mesh, and described salient point and Wound contact are to sterilize to wound by epidermal growth factor.
Preferably, this system also comprises display device, and this display device is used for the healing according to wound, medicine layer described in reminding user to replace.
On the other hand, the present invention also provides a kind of wound healing degree monitoring method, and the method comprises the steps:
First light source generates the light of first wave length;
By fiber coupler, the light of first wave length is sent to the first multimode fibre of intelligence sensor, the light of described first wave length passes second multimode fibre of single-mode fiber to intelligence sensor;
When photodiode receives the light of described first wave length from the second multimode fibre of intelligence sensor, produce photoelectric current when described photodiode is penetrated in the illumination of first wave length;
Processor is penetrated according to the illumination of first wave length the photoelectric current that photodiode produces and is calculated described matrix metalloproteinase sense film to the absorbance of the light of first wave length, and according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and absorbance, determine the level of activity of the matrix metalloproteinase sense film of current wound; And
Processor, according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and the healing of wound, determines the healing of current wound.
Preferably, described binder body comprises cover layer, medicine layer and adhesive layer, and described cover layer and medicine layer are pasted, and described medicine layer and adhesive layer are pasted, wherein:
Described medicine layer is provided with for pasting bonding strip on described adhesive layer and multiple salient point comprising epidermal growth factor, described salient point is arranged at the surface that described medicine layer and adhesive layer are pasted, the bonding strip of described medicine layer is arranged at the edge on the surface that described medicine layer and adhesive layer are pasted, and described medicine layer is a kind of adhesive structure that can tear from adhesive layer; And
Described adhesive layer is provided with multiple mesh and the bonding strip for pasting edge of wound, the bonding strip of described adhesive layer is arranged at the edge on described adhesive layer surface, when described adhesive layer and medicine layer are pasted, described salient point is embedded in described mesh, and described salient point and Wound contact are to sterilize to wound by epidermal growth factor.
Preferably, the method also comprises step: according to the healing of current wound, by medicine layer described in display device reminding user to replace.
Compared to prior art, wound healing degree monitoring system of the present invention have employed technique scheme, reaches following technique effect: the healing of monitoring wound, and reminds changing dressing for patient according to healing, is conducive to processing wound in time.
Accompanying drawing explanation
Fig. 1 is the functional frame composition of wound healing degree monitoring system of the present invention preferred embodiment;
Fig. 2 is the structural representation of intelligence sensor in wound healing degree monitoring system of the present invention;
Fig. 3 is schematic diagram when intelligence sensor is pasted on wound in wound healing degree monitoring system of the present invention;
Fig. 4 is the flow chart of the preferred embodiment of wound healing degree detecting method of the present invention;
Fig. 5 is the schematic diagram of the preferred embodiment of the corresponding relation preset between the level of activity of absorbance of the present invention and matrix metalloproteinase sense film;
Fig. 6 is the cross-sectional view of binder body preferred embodiment in wound healing degree monitoring system of the present invention;
Fig. 7 is the planar structure schematic diagram of the preferred embodiment of binder body drug layer of the present invention;
Fig. 8 is the planar structure schematic diagram of the preferred embodiment of adhered layer in binder body of the present invention;
Fig. 9 is the cross-sectional view that binder body bumps of the present invention is combined with mesh.
The realization of the object of the invention, functional characteristics and advantage will in conjunction with the embodiments, are described further with reference to accompanying drawing.
Detailed description of the invention
For further setting forth the present invention for the technological means reaching above-mentioned purpose and take and effect, below in conjunction with accompanying drawing and preferred embodiment, describe in detail bright to the specific embodiment of the present invention, structure, feature and effect thereof.Should be appreciated that specific embodiment described in the invention only in order to explain the present invention, be not intended to limit the present invention.
For realizing the object of the invention, the invention provides a kind of wound healing degree monitoring system, detecting the healing of wound, thus facilitating doctor or patient to understand the situation of wound, be conducive to the healing of wound.
As shown in Figure 1, Fig. 1 is the functional frame composition of wound healing degree monitoring system of the present invention preferred embodiment.In the present embodiment, described wound healing degree monitoring system 100 comprises monitoring equipment 1, binder body 2 and intelligence sensor 20.
Described monitoring equipment 1 comprises photodiode 10, first light source 121, secondary light source 122, fiber coupler 14, processor 16 and display device 18.Wherein, described first light source 121 and secondary light source 122 are connected with described fiber coupler 14, and described photodiode 10 is connected with described processor 16, and described processor 16 is connected with described display device 18.
The light of first wave length for generation of the light of first wave length, and is sent to described fiber coupler 14 by described first light source 121.In the present embodiment, the light of described first wave length is the light of 590 nanometers.
The light of second wave length for generation of the light of second wave length, and is sent to described fiber coupler 14 by described secondary light source 122.In the present embodiment, the light of described second wave length is the light of 860 nano wave lengths.
The light of first wave length and the light of second wave length are accumulated a branch of combined light by described fiber coupler 14, and correct the propagation path of combined light.Specifically, the light (i.e. the light of a branch of first wave length and the light of a branch of second wave length) of two bundle different wave lengths is become a branch of combined light by refraction and transmission by described fiber coupler 14, that is, the propagation path of light of two bundle different wave lengths is made to reach consistent.
Described photodiode 10 for receiving combined light, and the signal of telecommunication (namely the light of first wave length and the illumination of second wave length are mapped to the photoelectric current that photodiode 10 produces) corresponding to the light (i.e. optical signal) of the light of first wave length in combined light and second wave length converts to.In other embodiments, described photodiode 10 also can accept separately the light (or light of second wave length) of first wave length, the light (or light of second wave length) of first wave length is converted to the corresponding signal of telecommunication.
Described processor 16 is for the signal of telecommunication of the signal of telecommunication of light corresponding conversion and the light corresponding conversion of second wave length that obtain first wave length from described photodiode 10, and analyzing and processing is carried out, to monitor the healing of wound to the signal of telecommunication of the signal of telecommunication of the light corresponding conversion of described first wave length and the light corresponding conversion of second wave length.
Described display device 18 is for the signal of telecommunication of the light corresponding conversion of the signal of telecommunication and second wave length that show the light corresponding conversion of described first wave length, further, described display device 18 is also for showing the level of activity of matrix metalloproteinase sense film and the healing of wound of wound.
Described intelligence sensor 20 is arranged on the sticking veneer of binder body 2.This sticking veneer is provided with medical viscose glue, makes binder body 2 can be pasted on the skin of human body and not come off.Described intelligence sensor 20 can be positioned at the optional position (as long as described binder body 2 can cover described intelligence sensor 20 completely) of the sticking veneer of binder body 2.Described binder body 2 may be, but not limited to, medical proof fabric.
Shown in figure 2, Fig. 2 is the structural representation of intelligence sensor in wound healing degree monitoring system of the present invention, described intelligence sensor 20 comprises the first multimode fibre 201, second multimode fibre 203 and single-mode fiber 202, described single-mode fiber 202 between the first multimode fibre 201 and the second multimode fibre 203 and formed straight line connect.Described first multimode fibre 201, second multimode fibre 203 and single-mode fiber 202 are cylindrical.Described single-mode fiber 202 surface coverage has one deck matrix metalloproteinase sense film 2020, this matrix metalloproteinase sense film 2020, this matrix metalloproteinase sense film 2020 adopts colloidal sol and gel method preparation, this matrix metalloproteinase sense film 2020 comprises one deck and makes gel by cold water fish glue and the phosphate buffer containing a certain amount of glutaraldehyde, this gel does not have the copper chlorophyllin of biocompatible to dye with a kind of, can be monitored the healing of wound 3 by matrix metalloproteinase sense film 2020.When described binder body 2 is pasted on described wound 3, matrix metalloproteinase in described matrix metalloproteinase sense film and wound 3 reacts, matrix metalloproteinase in described wound 3 decomposes described matrix metalloproteinase sense film, matrix metalloproteinase sense film 2020 thickness and density are reduced, thus reduces the absorbance of matrix metalloproteinase sense film 2020 to the light of described first wave length.
The shape of described binder body 2 may be, but not limited to, rectangle, square, circle etc.In the present embodiment, for the ease of monitoring the healing of wound, described intelligence sensor 20 is arranged at the centre position of described binder body 2, when making binder body 2 just in time be pasted on wound, described intelligence sensor 20 is positioned at the position (region that in other words, wound is the most serious) of wound.As shown in Figure 3, when binder body 2 is pasted on wound 3, described intelligence sensor 20 is positioned on wound 3.
As shown in Figure 1, described fiber coupler 14 is connected with the first multimode fibre 201, described second multimode fibre 203 is connected with photodiode 10, combined light (be namely a branch of combined light that the light of 590 nanometers and the light of 860 nano wave lengths combine by wavelength) is transmitted into the first multimode fibre 201 by described fiber coupler 14, makes combined light pass the first multimode fibre 201, single-mode fiber 202 and the second multimode fibre 203.
When described combined light is propagated in described single-mode fiber 202, the absorption that described matrix metalloproteinase sense film 2020 can carry out in various degree to the light of first wave length, and described matrix metalloproteinase sense film 2020 affected the level of activity of the absorbance of the light of first wave length by the matrix metalloproteinase of wound 3.Default corresponding relation is had between the absorbance of light of described matrix metalloproteinase sense film 2020 pairs of first wave length and the level of activity of the matrix metalloproteinase sense film of wound 3, specifically, the level of activity of the matrix metalloproteinase sense film of wound 3 is larger, and the rate of change of the absorbance of the light of described matrix metalloproteinase sense film 2020 pairs of first wave length is higher (i.e. slope of a curve in Fig. 5).There is default corresponding relation between the absorbance of light of described matrix metalloproteinase sense film 2020 pairs of first wave length and the level of activity of the matrix metalloproteinase of wound 3, obtain according to great many of experiments test, and be stored in monitoring equipment 1.As shown in Figure 5, Fig. 5 is the schematic diagram of the preferred embodiment of the corresponding relation preset between the level of activity of absorbance of the present invention and matrix metalloproteinase sense film, curve is the absorbance of light in different time sections of described matrix metalloproteinase sense film 2020 pairs of first wave length, when the time is 1 day, slope of a curve is maximum, then the level of activity of described matrix metalloproteinase sense film is maximum.
In the present embodiment, it should be noted that, described photodiode 10 obtains the light of first wave length from described second multimode fibre 203, and converting the light of described first wave length to the signal of telecommunication, the signal of telecommunication converted to according to the light of described first wave length calculates the absorbance of the light of described matrix metalloproteinase sense film 2020 pairs of first wave length.The described signal of telecommunication refers on photodiode 10 because produced photoelectric current is penetrated in the illumination of first wave length.Wherein, the intensity of the light of first wave length is directly proportional to described photoelectric current.The light of described matrix metalloproteinase sense film 2020 pairs of first wave length carries out absorption in various degree, can weaken the intensity of the light of first wave length.
In the present embodiment, the illumination that the absorbance of the light of described matrix metalloproteinase sense film 2020 pairs of first wave length is first wave length is mapped to the rate of change of the photoelectric current that photodiode 10 produces.Specifically, a=c/b, wherein, b is the light of described first wave length photoelectric current of obtaining of described photodiode 10 when being absorbed, c is the light of the described first wave length photoelectric current that described photodiode 10 obtains when being absorbed by matrix metalloproteinase sense film 2020, a is the rate of change of photoelectric current, namely the absorbance of the light of described matrix metalloproteinase sense film 2020 pairs of first wave length.
When described combined light is propagated in described single-mode fiber 202, due to the matrix metalloproteinase sense film object properties on described matrix metalloproteinase sense film 2020, described matrix metalloproteinase sense film 2020 can not absorb the light of described second wave length (i.e. the light of 860 nano wave lengths), therefore, whether correctly the light path of combined light can be corrected by the light of second wave length.Specifically, described photodiode 10 obtains the light of second wave length from described second multimode fibre 203, and converts the light of described second wave length to the signal of telecommunication.The described signal of telecommunication refers on photodiode 10 because produced photoelectric current is penetrated in the illumination of second wave length.If the illumination of described second wave length penetrates produced photoelectric current in preset range (such as, between 30 microamperes to 40 microamperes), then show that the propagation path of combined light is correct, if the illumination of described second wave length penetrate produced photoelectric current not in preset range (such as, between 30 microamperes to 40 microamperes), show that the propagation path of combined light is incorrect, then adjust fiber coupler 14, make the illumination of described second wave length penetrate produced photoelectric current in preset range.
Further, as shown in Figure 6, Fig. 6 is the cross-sectional view of binder body preferred embodiment in wound healing degree monitoring system of the present invention, in the present embodiment, described binder body 2 is made up of trilaminate material, is respectively cover layer 22, medicine layer 24 and adhesive layer 26.Described cover layer 22 is pasted with medicine layer 24, and described medicine layer 24 is pasted with adhesive layer 26.
Wherein, described cover layer 22 is water proof non-woven gauze layer, this water proof non-woven gauze layer can effectively prevent external environment condition from polluting binder body 2, and described water proof non-woven gauze layer specifically can adopt waterproof cotton water thorn five to spin the water proof non-woven gauze layer of layer of cloth or other any appropriate.The surface that described cover layer 22 and medicine layer 24 are pasted scribbles medical cream, and cover layer 22 and medicine layer 24 are pasted.
As shown in Figure 7, Fig. 7 is the planar structure schematic diagram of the preferred embodiment of binder body drug layer.In the present embodiment, described medicine layer 24 comprises bonding strip 241, and this bonding strip 241 is positioned at the marginal position of medicine layer 24, and described bonding strip 241 is pasted with described adhesive layer 26, and described medicine layer 24 is pasted together with adhesive layer 26.In addition, the surface (namely described medicine layer 24 comprises the surface of bonding strip 241) that described medicine layer 24 and adhesive layer 26 are pasted has evenly or the salient point 240 of uneven distribution.Described salient point 240 may be, but not limited to, the salient point of circular salient point, rhombus salient point, square salient point, rectangle salient point or other shape.Described salient point 20 is for comprising the granule of epidermal growth factor (EpidermalGrowthFactor, EGF), and this granule comprising EGF can the organization healing of being wound of accelerated in wounds.General skin wound, uses EGF mono-to healing two days later, large-area burns, scald, under equal conditions, uses the healing rate after EGF to improve three-to-four-fold, and the skin ulcer such as corresponding cotton-padded mattress hemorrhoid, the simple EFG that uses can heal after ten days.
Due to described salient point 240 One's name is legion, in other embodiments, part salient point 240 is made up of the composite bed of moisture High hydrophilous resin, and the composite bed of this moisture High hydrophilous resin, for absorbing the sepage of the wound of skin, is conducive to the healing of the wound of skin.That is, in the salient point that medicine layer 24 is all, part is the salient point (also can be described as the first salient point) comprising epidermal growth factor, and part is the salient point (also can be described as the second salient point) comprising moisture High hydrophilous resin.Described medicine layer 24 can be gauze or medical plastic.It should be noted that, the described medicine layer 2 being pasted on described adhesive layer 3 surface can tear.That is, described medicine layer 2 is a kind of adhesive structures that can tear from adhesive layer 3, conveniently changes dressings, is conducive to the healing of the wound of skin, reduces the secondary injury to the wound of skin when changing dressings.
As shown in Figure 8, Fig. 8 is the planar structure schematic diagram of the preferred embodiment of adhered layer in binder body.In the present embodiment, the surface that described adhesive layer 26 and medicine layer 24 are pasted comprises multiple being evenly distributed or uneven mesh 260, and described mesh 260 may be, but not limited to, the mesh 260 of circle, rhombus, square, rectangle or other shape.Described adhesive layer 26 another side comprises bonding strip 260, and this bonding strip 260 is positioned at the edge of adhesive layer 26, and this bonding strip 260 is for pasting the edge of the wound of skin.This binder body 2 also includes intelligence sensor 20, and this intelligence sensor 20 is positioned at adhesive layer 26.
As shown in Figure 9, Fig. 9 is the cross-sectional view that binder body bumps is combined with mesh.Composition graphs 7 and Fig. 8, when described adhesive layer 26 is pasted with medicine layer 24, described salient point 240 to be embedded in described mesh 260 (as shown in Figure 9, salient point 240 is embedded into mesh 260), make described salient point 240 and the Wound contact of skin, the wound of skin is sterilized and/or absorbs wound exudate.Described adhesive layer 26 is gauze or medical plastic, this medical plastic frivolous (between 0.01 to 0.1 millimeter) and soft.
Present invention also offers a kind of wound healing degree monitoring method adopting above-mentioned wound healing degree monitoring system.As shown in Figure 4, Fig. 4 is the flow chart of the preferred embodiment of wound healing degree detecting method of the present invention.Composition graphs 1, in the present embodiment, described wound healing degree detecting method comprises the following steps:
Step S10: generate the light of first wave length and the light of second wave length.Particularly, generated the light of first wave length by the first light source 121, secondary light source 122 generates the light of second wave length.Specifically, the light of described first wave length is the light of 590 nanometers, and the light of described second wave length is the light of 860 nanometers.
Step S11: the light of first wave length and the light of second wave length are accumulated a branch of combined light by fiber coupler 14, and send to the first multimode fibre 201 with intelligence sensor 20.
Step S12: judge that whether the illumination of second wave length penetrates photoelectric current that photodiode produces in preset range.Particularly, photodiode 10 receives the light of first wave length combined light from the second multimode fibre 203 of intelligence sensor 20, and judge that whether the illumination of second wave length penetrates photoelectric current that photodiode 10 produces preset range (such as, between 30 microamperes to 40 microamperes).When the illumination of second wave length penetrates photoelectric current that photodiode 10 produces not in preset range, flow process enters step S13.When the illumination of second wave length penetrates photoelectric current that photodiode 10 produces in preset range, flow process enters step S14.
Step S13: the propagation path being adjusted combined light by described fiber coupler 14, until the illumination of second wave length penetrates photoelectric current that photodiode produces in preset range.
Step S14: described photodiode 10 receives the light of first wave length combined light from the second multimode fibre 203, when the light of calculating first wave length passes the single-mode fiber 202 of intelligence sensor 20, the matrix metalloproteinase sense film on single-mode fiber 202 surface is to the absorbance of the light of first wave length.Specifically, the illumination that the absorbance of the light of described matrix metalloproteinase sense film 2020 pairs of first wave length is first wave length is mapped to the rate of change of the photoelectric current that photodiode 10 produces.Specifically, a=c/b, wherein, b is the light of described first wave length photoelectric current of obtaining of described photodiode 10 when being absorbed, c is the light of the described first wave length photoelectric current that described photodiode 10 obtains when being absorbed by described matrix metalloproteinase sense film 2020, a is the rate of change of photoelectric current, namely the absorbance of the light of described matrix metalloproteinase sense film 2020 pairs of first wave length.
Step S15: processor 16, according to the corresponding relation preset between the absorbance of light of described matrix metalloproteinase sense film 2020 pairs of first wave length and the level of activity of the matrix metalloproteinase sense film of wound, determines the level of activity of the matrix metalloproteinase sense film of current wound 3.Specifically, as shown in Figure 5, when the time is 1 day, the level of activity of matrix metalloproteinase sense film is maximum, and afterwards, the level of activity of matrix metalloproteinase sense film diminishes, until the level of activity vanishing of matrix metalloproteinase sense film.
Step S16: described processor 16 is according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and the healing of wound, determine the healing of current wound 3, and pass through the healing of the current wound of the current display of display device 18.Specifically, if the level of activity vanishing of matrix metalloproteinase sense film, represent that wound 3 heals, if the level of activity of matrix metalloproteinase sense film is maximum, represent that wound 3 is in healing minimum.
It should be noted that, in above-mentioned flow chart, secondary light source 122 can not generate the light of second wave length, thus, just the light of first wave length is sent to the first multimode fibre 201 with intelligence sensor 20, and step S12 and S13 can omit in step S11.
These are only preferred embodiment of the present invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention and accompanying drawing content to do equivalent structure or equivalent function conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (10)
1. a wound healing degree monitoring system, it is characterized in that, this system comprises: monitoring equipment, binder body and the intelligence sensor be arranged on binder body, wherein, described monitoring equipment comprises photodiode, the first light source, fiber coupler and processor, described photodiode is connected with described processor, and described first light source is connected with described fiber coupler;
Described intelligence sensor comprises the first multimode fibre, the second multimode fibre and single-mode fiber, described single-mode fiber between described first multimode fibre and described second multimode fibre and formed straight line connect, described single-mode fiber surface-coated has one deck matrix metalloproteinase sense film, when described binder body is pasted on wound, described intelligence sensor is positioned on wound;
Described fiber coupler is connected with described first multimode fibre, and described second multimode fibre is connected with described photodiode;
Described first light source, for generation of the light of first wave length, and sends to described fiber coupler by the light of described first wave length;
Described fiber coupler, for giving described first multimode fibre by the optical transport of described first wave length, the light of described first wave length is through described single-mode fiber extremely described second multimode fibre;
Described photodiode, for receiving the light of first wave length from the second multimode fibre, and photoelectric current when described photodiode is penetrated in the illumination producing first wave length;
Described processor, the photoelectric current produced for penetrating photodiode according to the illumination of first wave length calculates described matrix metalloproteinase sense film to the absorbance of the light of first wave length, and according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and absorbance, determine the level of activity of the matrix metalloproteinase sense film of current wound; And
Described processor, also for according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and the healing of wound, determines the healing of current wound.
2. wound healing degree monitoring system as claimed in claim 1, it is characterized in that, described matrix metalloproteinase sense film is mapped to the rate of change of the photoelectric current that photodiode produces to the illumination that the absorbance of the light of first wave length is first wave length.
3. wound healing degree monitoring system as claimed in claim 1, it is characterized in that, described monitoring equipment also comprises secondary light source, this secondary light source is connected with described fiber coupler, this secondary light source is for generation of the light of second wave length, this fiber coupler also for the light of first wave length and the light of second wave length are accumulated a branch of combined light, and is transmitted into the first multimode fibre, and described combined light is through described single-mode fiber extremely described second multimode fibre.
4. wound healing degree monitoring system as claimed in claim 3, it is characterized in that, described photodiode, also for receiving the light of second wave length in described combined light from the second multimode fibre, and the photoelectric current of the illumination producing second wave length when penetrating photodiode, if when photoelectric current when photodiode is penetrated in the illumination of this second wave length is not in preset range, the transmission path of the light of first wave length and the light of second wave length is corrected, until photoelectric current when photodiode is penetrated in the illumination of second wave length is in preset range by described fiber coupler.
5. wound healing degree monitoring system as claimed in claim 1, is characterized in that, described in comprise one deck and make gel by cold water fish glue and the phosphate buffer containing a certain amount of glutaraldehyde, this gel does not have the copper chlorophyllin of biocompatible to dye with a kind of.
6. the wound healing degree monitoring system according to any one of claim 1 to 5, is characterized in that, described binder body comprises cover layer, medicine layer and adhesive layer, and described cover layer and medicine layer are pasted, and described medicine layer and adhesive layer are pasted, wherein:
Described medicine layer is provided with for pasting bonding strip on described adhesive layer and multiple salient point comprising epidermal growth factor, described salient point is arranged at the surface that described medicine layer and adhesive layer are pasted, the bonding strip of described medicine layer is arranged at the edge on the surface that described medicine layer and adhesive layer are pasted, and described medicine layer is a kind of adhesive structure that can tear from adhesive layer; And
Described adhesive layer is provided with multiple mesh and the bonding strip for pasting edge of wound, the bonding strip of described adhesive layer is arranged at the edge on described adhesive layer surface, when described adhesive layer and medicine layer are pasted, described salient point is embedded in described mesh, and described salient point and Wound contact are to sterilize to wound by epidermal growth factor.
7. wound healing degree monitoring system as claimed in claim 6, it is characterized in that, this system also comprises display device, and this display device is used for the healing according to wound, medicine layer described in reminding user to replace.
8. adopt a wound healing degree monitoring method for the wound healing degree monitoring system according to any one of claim 1 to 7, it is characterized in that, the method comprises the steps:
First light source generates the light of first wave length;
By fiber coupler, the light of first wave length is sent to the first multimode fibre of intelligence sensor, the light of described first wave length passes second multimode fibre of single-mode fiber to intelligence sensor;
When photodiode receives the light of described first wave length from the second multimode fibre of intelligence sensor, produce photoelectric current when described photodiode is penetrated in the illumination of first wave length;
Processor is penetrated according to the illumination of first wave length the photoelectric current that photodiode produces and is calculated described matrix metalloproteinase sense film to the absorbance of the light of first wave length, and according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and absorbance, determine the level of activity of the matrix metalloproteinase sense film of current wound; And
Processor, according to the corresponding relation preset between the level of activity of matrix metalloproteinase sense film and the healing of wound, determines the healing of current wound.
9. wound healing degree monitoring method as claimed in claim 8, it is characterized in that, described binder body comprises cover layer, medicine layer and adhesive layer, and described cover layer and medicine layer are pasted, and described medicine layer and adhesive layer are pasted, wherein:
Described medicine layer is provided with for pasting bonding strip on described adhesive layer and multiple salient point comprising epidermal growth factor, described salient point is arranged at the surface that described medicine layer and adhesive layer are pasted, the bonding strip of described medicine layer is arranged at the edge on the surface that described medicine layer and adhesive layer are pasted, and described medicine layer is a kind of adhesive structure that can tear from adhesive layer; And
Described adhesive layer is provided with multiple mesh and the bonding strip for pasting edge of wound, the bonding strip of described adhesive layer is arranged at the edge on described adhesive layer surface, when described adhesive layer and medicine layer are pasted, described salient point is embedded in described mesh, and described salient point and Wound contact are to sterilize to wound by epidermal growth factor.
10. wound healing degree monitoring method as claimed in claim 9, it is characterized in that, the method also comprises step: according to the healing of current wound, by medicine layer described in display device reminding user to replace.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510581442.4A CN105250075A (en) | 2015-09-12 | 2015-09-12 | Wound healing degree monitoring system and method |
| PCT/CN2015/098614 WO2017041385A1 (en) | 2015-09-12 | 2015-12-24 | System and method for monitoring extent of wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510581442.4A CN105250075A (en) | 2015-09-12 | 2015-09-12 | Wound healing degree monitoring system and method |
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| CN105250075A true CN105250075A (en) | 2016-01-20 |
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| CN201510581442.4A Withdrawn CN105250075A (en) | 2015-09-12 | 2015-09-12 | Wound healing degree monitoring system and method |
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| CN (1) | CN105250075A (en) |
| WO (1) | WO2017041385A1 (en) |
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| CN108309250A (en) * | 2018-03-20 | 2018-07-24 | 南通大学附属医院 | Wound healing degree monitoring device and monitoring method |
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| SG11201809829UA (en) | 2016-05-13 | 2018-12-28 | Smith & Nephew | Sensor enabled wound monitoring and therapy apparatus |
| EP3592230A1 (en) | 2017-03-09 | 2020-01-15 | Smith & Nephew PLC | Apparatus and method for imaging blood in a target region of tissue |
| EP3592212B1 (en) | 2017-03-09 | 2024-08-07 | Smith & Nephew plc | Wound dressing |
| US12178597B2 (en) | 2017-03-09 | 2024-12-31 | Smith & Nephew Plc | Device, apparatus and method of determining skin perfusion pressure |
| SG11201909449TA (en) | 2017-04-11 | 2019-11-28 | Smith & Nephew | Component positioning and stress relief for sensor enabled wound dressings |
| WO2018210693A1 (en) | 2017-05-15 | 2018-11-22 | Smith & Nephew Plc | Negative pressure wound therapy system using eulerian video magnification |
| WO2018210692A1 (en) | 2017-05-15 | 2018-11-22 | Smith & Nephew Plc | Wound analysis device and method |
| US11633153B2 (en) | 2017-06-23 | 2023-04-25 | Smith & Nephew Plc | Positioning of sensors for sensor enabled wound monitoring or therapy |
| GB201804502D0 (en) | 2018-03-21 | 2018-05-02 | Smith & Nephew | Biocompatible encapsulation and component stress relief for sensor enabled negative pressure wound therapy dressings |
| GB201809007D0 (en) | 2018-06-01 | 2018-07-18 | Smith & Nephew | Restriction of sensor-monitored region for sensor-enabled wound dressings |
| WO2019030384A2 (en) | 2017-08-10 | 2019-02-14 | Smith & Nephew Plc | Positioning of sensors for sensor enabled wound monitoring or therapy |
| GB201804971D0 (en) | 2018-03-28 | 2018-05-09 | Smith & Nephew | Electrostatic discharge protection for sensors in wound therapy |
| GB201718870D0 (en) | 2017-11-15 | 2017-12-27 | Smith & Nephew Inc | Sensor enabled wound therapy dressings and systems |
| WO2019048624A1 (en) | 2017-09-10 | 2019-03-14 | Smith & Nephew Plc | Systems and methods for inspection of encapsulation and components in sensor equipped wound dressings |
| GB201718859D0 (en) | 2017-11-15 | 2017-12-27 | Smith & Nephew | Sensor positioning for sensor enabled wound therapy dressings and systems |
| CN111132605B (en) | 2017-09-27 | 2023-05-16 | 史密夫及内修公开有限公司 | PH sensing for negative pressure wound monitoring and treatment device implementing sensor |
| EP3687396A1 (en) | 2017-09-28 | 2020-08-05 | Smith & Nephew plc | Neurostimulation and monitoring using sensor enabled wound monitoring and therapy apparatus |
| WO2019096828A1 (en) | 2017-11-15 | 2019-05-23 | Smith & Nephew Plc | Integrated sensor enabled wound monitoring and/or therapy dressings and systems |
| GB2592508B (en) | 2018-09-12 | 2022-08-31 | Smith & Nephew | Device, apparatus and method of determining skin perfusion pressure |
| EP3856104A1 (en) * | 2018-09-28 | 2021-08-04 | T.J.Smith And Nephew, Limited | Optical fibers for optically sensing through wound dressings |
| GB201816838D0 (en) | 2018-10-16 | 2018-11-28 | Smith & Nephew | Systems and method for applying biocompatible encapsulation to sensor enabled wound monitoring and therapy dressings |
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| EP1411816A4 (en) * | 2001-07-09 | 2005-09-28 | Univ Arizona State | AFFINITY BIOSENSOR FOR MONITORING BIOLOGICAL PROCESSES |
| US20030125783A1 (en) * | 2001-12-18 | 2003-07-03 | Ceramoptec Industries, Inc. | Device and method for wound healing and debridement |
| US20070142762A1 (en) * | 2005-12-16 | 2007-06-21 | Eastman Kodak Company | Wound dressing |
| JP2014503252A (en) * | 2010-11-30 | 2014-02-13 | エーブリー デニソン コーポレイション | Sensing patch application |
| CN202355706U (en) * | 2011-11-29 | 2012-08-01 | 西安精英光电技术有限公司 | Wound auxiliary healing device of optical laser |
| CN105105716A (en) * | 2015-09-12 | 2015-12-02 | 深圳市前海安测信息技术有限公司 | Intelligent sensor used for detecting healing degree of wound and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108309250A (en) * | 2018-03-20 | 2018-07-24 | 南通大学附属医院 | Wound healing degree monitoring device and monitoring method |
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