CN106581747A - Strontium-containing bone cement and preparation method - Google Patents

The invention provides a strontium-containing bone cement and a preparation method. The bone cement consists of two parts, namely a powder body and liquid; the powder body comprises polyacrylate which contains benzoyl peroxide, a developing agent, calcium salt and strontium ranelate; the liquid comprises methacrylate which contains hydroquinone, N,N-dimethyl-p-toluidine and strontium ranelate; by adding the strontium ranelate to the bone cement, a methacrylate polymer which contains the strontium ranelate is generated, so that heat energy release when the bone cement is polymerized is relieved, curing temperature of the bone cement is reduced, injection performance of the bone cement is enhanced, sufficient operating time is offered to doctors and operating risks are reduced; with the addition of the strontium ranelate, the mechanical performance of the bone cement is improved, so that mechanical performance matching required by human body is relieved, and the biocompatibility and bone regeneration performance of the bone cement are enhanced; and the prepared bone cement, which is higher than 50MPa in compressive strength, can meet a demand of human body bone repair; therefore, the prepared bone cement is a bone repair material which is excellent in performance.

A kind of strontium phosphate cement and preparation method

Technical field

The present invention relates to a kind of strontium phosphate cement and preparation method, are mainly used in the fields such as bio-medical material.

Background technology

Acrylate bone cement is that it is by powder and liquid two parts group at present clinically using a kind of most bone cements Into.Powder main component is polyacrylate, barium sulfate, benzoyl peroxide (initiator, BPO), and liquid main component is first Base acrylate (MMA) monomer, N, N dimethyl para-totuidine and hydroquinones.Acrylate bone cement injection moldable and system Into arbitrary shape, mechanical strength is high, but while acrylate bone cement also having some limitations property, such as monomer have certain poison Property, biocompatibility is not good enough, and after injection human body degraded can not be absorbed, while it is without osteogenic action, Yi Song insecure with synosteosis It is dynamic, and the exothermic reaction in polymerization process is likely to result in nervous function damage etc..For bone cement polymerisation reactivity high temperature pair Surrounding tissue causes obvious fire damage, causes a series of complication such as local inflammation, necrosis, and many research reports are by changing Become bone cement self-characteristic, improve the method effectively prevention of bone cement correlation technique or mitigate bone cement fire damage.

Bone cement will not only reduce in use injury of the bone cement heat release to surrounding tissue, also keep bone cement to have Good biological nature.Calcium sulfate, calcium phosphate are good bioactive materials, and calcium sulfate solidification intensity is moderate, calcium phosphate tool There are good biologically active, biocompatibility and syringeability.Calcium sulfate, calcium phosphate are added in bone cement and are increased by many schemes Add biologically active, the biocompatibility of bone cement, but can not reduce or slow down the exothermic reaction of bone cement, do not reduce bone water The solidification temperature of mud.

Strontium Ranelate is mainly used in treating and preventing the osteoporosis of postmenopausal women, significantly reduces vertebral fracture and hipbone The danger that fracture occurs, can suppress in vivo the reabsorption of bone, the formation of bone can be promoted again, in vivo and in vitro with good life Thing activity, bioavilability and tolerance.

Strontium Ranelate with biologically active is added to the solidification temperature of reduction bone cement in bone cement in the present invention, by In the addition of Strontium Ranelate, partly it is polymerized with MMA, reduces the release of bone cement curing heat, and extends the solidification of bone cement Time, increase the heat release time of bone cement, reduce the accumulation of heat, reduce the solidification temperature of bone cement；Integration is solved What prior art was present can not reduce or slow down the exothermic reaction of bone cement, not reduce the problem of the solidification temperature of bone cement.

The content of the invention

It is an object of the invention to provide a kind of strontium phosphate cement and preparation method；For bone tissue reparation with low-heat The bone cement containing Strontium Ranelate of amount release.The present invention is added to Strontium Ranelate bone cement in bone cement, Strontium Ranelate Addition improves the curing performance of bone cement, extends the injection time of bone cement, reduces exothermic reaction and the solidification temperature of bone cement Spend, and Strontium Ranelate is added in bone cement, and strontium ion is discharged in vivo, induces bone cell growth, accelerates Cranial defect position Repair and treatment, for the research of related content of the present invention has no report.

Bone cement is made up of powder and liquid two parts, and powder main component is polyacrylate, calcium sulfate, calcium phosphate It is methacrylate Deng, liquid main component, Strontium Ranelate adds the hardening time for extending bone cement in the present invention, increases bone The injection property of cement, reduces the heat release of bone cement, improves the osteoinductive and mechanical property of bone cement.

Bone cement powder main component is the polyacrylate containing benzoyl peroxide, developer, it is also possible to containing calcium Salt, liquid main component is methacrylate, and the content of Strontium Ranelate is 0.01～2% in bone cement.

Bone cement concrete composition and weight/mass percentage composition are as follows：

Powder：

Polyacrylate 49～89% containing benzoyl peroxide；

Developer 10～30%；

Calcium salt 0～40%；

Strontium Ranelate 0.01～1%；

Liquid：

Methacrylate 94～99.9% containing hydroquinones；

N, N dimethyl para-totuidine 0.1～5%；

Strontium Ranelate 0～1%.

In bone cement powder, preferred size distribution is 1～100 μm of Strontium Ranelate powder；

Calcium salt is calcium phosphate, one kind of calcium sulfate or mixture, and when calcium salt content is 0, preparation is containing Strontium Ranelate Acrylate bone cement.

Developer is barium sulfate, zirconic one kind.

The preparation method of bone cement is according to following steps：

(1) Strontium Ranelate, the polyacrylate containing benzoyl peroxide, development are weighed according to the weight/mass percentage composition of powder Agent, calcium salt, are uniformly mixed to get bone cement powder；

(2) weigh Strontium Ranelate according to weight/mass percentage composition and be added to the methacrylate containing hydroquinones, N, N diformazans In base para-totuidine, bone cement liquid is mixed to get；

(3) according to powder liquid mass ratio 1～3:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, Bone cement injection time is 5～12min.

It is an advantage of the current invention that：A small amount of Strontium Ranelate is added in bone cement, when bone cement is polymerized, Strontium Ranelate With methacrylate, the methacrylate polymers containing Strontium Ranelate are generated, reduce heat when bone cement is polymerized Release, reduces the solidification temperature of bone cement, extends the injection property of bone cement, gives doctor enough operating times, reduces Operation risk, and the heat release of bone cement is reduced, beneficial to scattering and disappearing for position heat is repaired, the accumulative of heat is reduced, reduce bone The solidification temperature of cement, greatly reduces infringement of the acrylate bone cement curing exotherm to human body, and the addition of Strontium Ranelate, changes The mechanical property of kind bone cement so as to be reduced to be matched with needed by human body mechanical property, increase bone cement biocompatibility and Osteanagenesis, and the compression strength of the bone cement for preparing meets the needs of human body Bone Defect Repari in more than 50MPa, is a kind of property The excellent bone renovating material of energy.

Description of the drawings

Fig. 1：The operation chart of bone cement；

Fig. 2：The solidification maximum temperature of bone cement, time comparison diagram；

Fig. 3：The mean compressive strength of bone cement.

Specific embodiment

Present disclosure is described in further detail with reference to embodiment, but embodiments of the present invention are not limited In this.

Embodiment 1

(1) weigh corresponding Strontium Ranelate (1%) according to the weight/mass percentage composition of powder, it is poly- containing benzoyl peroxide Acrylate (59%), barium sulfate (10%), calcium sulfate (15%) and calcium phosphate (15%), are uniformly mixed to get bone cement powder Body, common 20g；

(2) methacrylate (95%), N containing hydroquinones are measured, N dimethyl para-totuidine (5%), common 15g is obtained To bone cement liquid；

(3) according to powder liquid mass ratio 1.33:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, Bone cement injection time is 12min.

Shown in operability as accompanying drawing 1-A, bone cement 3min injectables are used, and have the injection time of 12min, finally 20min solidifies, and compares with the not strontium phosphate cement of accompanying drawing 1-B, and the addition of Strontium Ranelate, the injection time of bone cement is prolonged by 6min Grow to 12min.

Requirement and the solidification temperature of method measure bone cement according to standard, from Fig. 2-C/D, the bone cement highest temperature Spend for 63 DEG C, hardening time 17min, 87 DEG C of the bone cement maximum temperature without Strontium Ranelate, hardening time 12min, Liang Zhexiang Relatively, add after Strontium Ranelate, the maximum temperature of bone cement differs 24 DEG C, and the release of bone cement heat is substantially reduced hardening time Extend 5min.

Requirement and the compression strength of method measure bone cement according to standard, sample is cylindric (Φ 6mm × 12mm), is resisted Compressive Strength mean value is 60.15Mpa (as shown in accompanying drawing 3-a).

Embodiment 2：

(1) weigh corresponding Strontium Ranelate (0.01%) according to the weight/mass percentage composition of powder, containing benzoyl peroxide Polyacrylate (49%), barium sulfate (30%), calcium sulfate (10.99%) and calcium phosphate (10%), are uniformly mixed to get bone water Mud powder, common 20g；

(2) weigh Strontium Ranelate (1%) and be added to methacrylate (94%), N containing hydroquinones, N dimethyl pair In toluidines (5%), it is well mixed and obtains bone cement liquid, common 10g；

(3) according to powder liquid mass ratio 2:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, bone water Mud injection time is 9min.

Requirement and the solidification temperature of method measure bone cement according to standard, from Fig. 2-E, the bone cement maximum temperature For 66 DEG C, hardening time 16min.

Requirement and the compression strength of method measure bone cement according to standard, sample is cylindric (Φ 6mm × 12mm), is resisted Compressive Strength mean value is 65.32Mpa (as shown in accompanying drawing 3-b).

Embodiment 3

(1) weigh corresponding Strontium Ranelate (0.2%) according to the weight/mass percentage composition of powder, it is poly- containing benzoyl peroxide In acrylate (49.8%), barium sulfate (10%), calcium sulfate (30%) and calcium phosphate (10%), bone cement is uniformly mixed to get Powder, common 20g；

(2) weigh Strontium Ranelate (0.3%) and be added to methacrylate (96.9%), N containing hydroquinones, N diformazans In base para-totuidine (2.8%), it is well mixed and obtains bone cement liquid, common 20g；

(3) according to powder liquid mass ratio 1:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, bone water Mud injection time is 12min.

Requirement and the solidification temperature of method measure bone cement according to standard, from Fig. 2-F, the bone cement maximum temperature For 59 DEG C, hardening time 19min.

Requirement and the compression strength of method measure bone cement according to standard, sample is cylindric (Φ 6mm × 12mm), is resisted Compressive Strength mean value is 52.55Mpa (as shown in accompanying drawing 3-c).

Embodiment 4

(1) weigh corresponding Strontium Ranelate (0.5%) according to the weight/mass percentage composition of powder, it is poly- containing benzoyl peroxide Acrylate (89%), zirconium oxide (10.5%), are uniformly mixed to get bone cement powder, common 20g；

(2) weigh Strontium Ranelate (0.2%) and be added to methacrylate (99.7%), N containing hydroquinones, N diformazans In base para-totuidine (0.1%), it is well mixed and obtains bone cement liquid, common 10g；

(3) according to powder liquid mass ratio 2:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, bone water Mud injection time is 5min.

Requirement and the solidification temperature of method measure bone cement according to standard, from Fig. 2-G, the bone cement maximum temperature For 70 DEG C, hardening time 14min.

Requirement and the compression strength of method measure bone cement according to standard, sample is cylindric (Φ 6mm × 12mm), is resisted Compressive Strength mean value is 70.1Mpa (as shown in accompanying drawing 3-d).

Embodiment 5

(1) weigh corresponding Strontium Ranelate (0.3%) according to the weight/mass percentage composition of powder, it is poly- containing benzoyl peroxide Acrylate (67.7%), zirconium oxide (30%), calcium sulfate (2%) is uniformly mixed to get bone cement powder, common 21g；

(2) weigh Strontium Ranelate (0.2%) and be added to methacrylate (97.8%), N containing hydroquinones, N diformazans In base para-totuidine (2%), it is well mixed and obtains bone cement liquid, common 7g；

(3) according to powder liquid mass ratio 3:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, bone water Mud injection time is 5min.

Requirement and the solidification temperature of method measure bone cement according to standard, from Fig. 2-H, the bone cement maximum temperature For 64 DEG C, hardening time 17min.

Requirement and the compression strength of method measure bone cement according to standard, sample is cylindric (Φ 6mm × 12mm), is resisted Compressive Strength mean value is 61.73Mpa (as shown in accompanying drawing 3-e).

Embodiment 6

(1) weigh corresponding Strontium Ranelate (0.2%) according to the weight/mass percentage composition of powder, it is poly- containing benzoyl peroxide Acrylate (55%), zirconium oxide (24%), calcium phosphate (20.8%) is uniformly mixed to get bone cement powder, common 20g；

(2) weigh Strontium Ranelate (0.6%) and be added to methacrylate (96.4%), N containing hydroquinones, N diformazans In base para-totuidine (3%), it is well mixed and obtains bone cement liquid, common 10g；

(3) according to powder liquid mass ratio 2:1, powder is added and is well mixed in liquid, solidification obtains strontium phosphate cement, bone water Mud injection time is 7min.

Requirement and the solidification temperature of method measure bone cement according to standard, from Fig. 2-I, the bone cement maximum temperature For 55 DEG C, hardening time 15min.

Requirement and the compression strength of method measure bone cement according to standard, sample is cylindric (Φ 6mm × 12mm), is resisted Compressive Strength mean value is 53.26Mpa (as shown in accompanying drawing 3-f).