CN106924162A - A kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared - Google Patents

The present invention relates to oral care product technical field, there is provided a kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared.Plant additive, including at least three kinds separable plant extracts each other, plant extracts are selected from green-tea extract, mint extract, emblic extract, licorice and propolis extract.The additive effect is comprehensive.Bacteriostatic agent, is made up of above-mentioned plant additive.The bacteriostatic agent has good sterilized sterilization functions.The plant additive can be applicable in preparing oral care product.Oral care product, is made up of raw material, and raw material includes above-mentioned plant additive, and plant additive mass percent in the feed is 5.2%~42%.The oral care product can not only prevent bleeding gums, repair oral mucosa, eliminates oral peculiar smell, but also can kill the various bacteriums in oral cavity.

A kind of plant additive, bacteriostatic agent, oral care product and plant additive are in system Application in standby oral care product

Technical field

The present invention relates to oral care product technical field, in particular to a kind of plant additive, bacteriostatic agent, mouth The application of chamber care product and plant additive in oral care product is prepared.

Background technology

With the improvement of people's living standards, increasing people's concern oral health, it is understood that oral health is very Important, oral health care products the more commonly used at present mainly have following a few classes：Toothpaste：Toothpaste is commonly used in daily life Cleaning supplies, with continuing to develop for science and technology, technological equipment is updated and perfect, and various types of toothpaste ask in succession Generation, the quality and class of product are improved constantly, and present toothpaste variety by single clean type toothpaste, develops into kind neat Entirely, it is vdiverse in function, the up to a hundred Mobyneb toothpaste of brand, the need for meeting the different levels level of consumption.Mouthwash：It is more next More people promote oral health, water energy of gargling cleaning oral cavity, pre- anti-caries and periodontitis etc. using mouthwash.Mouthspray： With clearing heat and detoxicating, effect of anti-inflammatory analgetic.

However, at present, effect of these oral care products is all relatively simple, goes out in particular for general prevention and treatment gum Blood, repairs oral mucosa, eliminates oral peculiar smell, and kill the aspects such as oral bacteria.Therefore, a kind of full-featured mouth is developed Chamber care product becomes current problem demanding prompt solution.

The content of the invention

The first object of the present invention is to provide a kind of plant additive, and the additive effect is comprehensive.

The second object of the present invention is to provide a kind of bacteriostatic agent, and the bacteriostatic agent has good sterilized sterilization functions.

The third object of the present invention is the application for providing a kind of plant additive in oral care product is prepared.

The fourth object of the present invention is to provide a kind of oral care product, and the oral care product can not only prevent tooth Oulorrhagia, reparation oral mucosa, elimination oral peculiar smell, but also the various bacteriums in oral cavity can be killed.

The present invention is solved its technical problem and is realized using following technical scheme：

A kind of plant additive, including at least three kinds separable plant extracts each other, plant extracts are selected from green tea Extract, mint extract, emblic extract, licorice and propolis extract.

A kind of bacteriostatic agent, is made up of above-mentioned plant additive.

A kind of application of above-mentioned plant additive in oral care product is prepared.

A kind of oral care product, is made up of raw material, and raw material includes above-mentioned plant additive, and plant additive is in the feed Mass percent be 5.2%~42%.

A kind of plant additive, bacteriostatic agent, oral care product and the plant additive that the present invention is provided are preparing mouth The beneficial effect of the application in the care product of chamber is：

The plant additive that the present invention is provided includes at least three kinds separable plant extracts each other, plant extracts tool There is pure natural function, it is harmless；At least three kinds be set with is beneficial to promote the function of obtained plant additive more complete Face；Separable being set with can be added in other products beneficial to obtained plant additive in wider form each other, Extend its range of application；Plant extracts is selected from green-tea extract, mint extract, emblic extract, licorice And propolis extract, above several plant extract is respectively provided with natural restraining and sterilizing bacteria ability, and each plant extracts mutually it Between can play coordinated effect, play more fully hereinafter protection and health care effect.

The bacteriostatic agent that the present invention is provided, is made up of above-mentioned plant additive, because the plant additive tool that the present invention is provided There is good restraining and sterilizing bacteria function, therefore can based on this be made the bacteriostatic agent with good restraining and sterilizing bacteria function.

Application of the plant additive that the present invention is provided in oral care product is prepared, the plant addition that the present invention is provided Agent is pure natural, harmless, and with the comprehensive function of multiple-effect, therefore can apply in oral care product is prepared.

The oral care product that the present invention is provided, is made up of raw material, and raw material includes above-mentioned plant additive, plant additive Mass percent in the feed is 5.2%~42%.Plant additive is tried in the content of oral care product by creative Test and obtain, in the range of the mass percent, obtained oral care product prevent bleeding gums, repair oral mucosa, disappear Removing abnormal flavor in oral cavity, and restraining and sterilizing bacteria best results.

Specific embodiment

To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below will be in the embodiment of the present invention Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional product that can be obtained by commercially available purchase Product.

Plant additive following to the embodiment of the present invention, bacteriostatic agent, oral care product and plant additive are in system Application in standby oral care product is specifically described.

Plant additive provided in an embodiment of the present invention, including plant extracts.Plant extracts be with plant as raw material, The need for purposes according to the final products to extracting, separation process is extracted by physical chemistry, orientation is obtained and concentration plant In a certain kind or plurality of active ingredients, the product formed without changing its active ingredient structure, plant extracts is natural, right Human body is harmless, is particularly suitable for playing health-care assistance effect as additive.

It should be noted that the species of plant extracts is not particularly limited, it is contemplated that in order that obtained plant is added The function of agent is more comprehensive, in this embodiment, it is preferred that, plant extracts is at least three kinds.

Combination between various plants extract is not particularly limited, in the present embodiment, it is contemplated that, plant additive was both Direct effect can be carried out to human body as entirety, have to be added in other products as additive human body is made indirectly With, it is preferable that be can be separated between various plant additives.

The selection of plant extracts is not particularly limited, and every plant extracts that can play antibacterial and bacteriostasis all should It is included, in the present embodiment, preferably, plant extracts is selected from green-tea extract, mint extract, emblic and carries Take thing, licorice and propolis extract.

Green-tea extract is the active component extracted from green tea blade, mainly including Tea Polyphenols (catechin) etc..Have The effects such as disinfecting detoxifying, anti-oxidant, removing free radical, detoxicating and raising immunity of organisms；Mint extract has fragrant pure and fresh Pleasant fragrance；Emblic extract has removes free radical and oxidation resistant effect；Licorice has anti-inflammatory and resists exempts from Epidemic disease, it is clearing heat and detoxicating, and skin whitening effect；Propolis extract has various functions such as antibacterial, anti-inflammatory, antipruritic, anti-oxidant.

Above several plant extract can play coordinated effect each other, can more fully hereinafter play protection With effect of health care.

It should be noted that the formulation of any of the above plant extracts is not specifically limited, including pulvis, tablet, paste Deng in the present embodiment, it is contemplated that be easy to easily be measured when easily packing or be added separately during unified sale, therefore its formulation It is identical.Compared to other formulations, pulvis is easier to carry, and addition is also easier to as additive, therefore in the present embodiment, it is excellent Selection of land, using pulvis.

Bacteriostatic agent provided in an embodiment of the present invention, is made up of plant additive provided in an embodiment of the present invention.

In embodiments of the present invention, bacteriostatic agent can in plant additive various plants extract be combined together it is laggard Sold together after row sale, or various plants extract independent packaging.

In embodiments of the present invention, in order to improve antibacterial effect, in the present embodiment, preferably, bacteriostatic agent bag Include green-tea extract, mint extract, emblic extract, licorice and propolis extract.

It should be noted that green-tea extract, mint extract, emblic extract, licorice and propolis are carried The proportioning consumption for taking thing is not particularly limited, in the present embodiment, in order to reach optimal antibacterial bacteriostatic effect, by inventor Creativeness experiment draws, counts by weight, green-tea extract 0.5-5.5 parts, mint extract 6.5-8.5 parts, emblic carries Take thing 0.5-1.5 parts, licorice 1.5-2.5 parts and propolis extract 0.5-5.5 parts.

Inventor is by creative experiment discovery, this plant additive provided in an embodiment of the present invention, not only with good Good antibacterial and bacteriostasis, and have significantly to preventing and treating bleeding gums, repairing oral mucosa and eliminating oral peculiar smell etc. Effect, therefore, the plant additive can be applied in oral care product is prepared.

A kind of oral care product provided in an embodiment of the present invention, the product is made up of raw material, in order to obtain good controlling Bleeding gums are treated, the oral health benefits such as oral mucosa, antibacterial bacteriostatic are repaired, raw material includes plant provided in an embodiment of the present invention Additive.

The addition of plant additive is not particularly limited, and in embodiments of the present invention, the creative experiment of inventor draws, When plant additive mass percent in the feed is 5.2%~42%, preferably above-mentioned oral health effect can be obtained Really, when the mass percent especially when plant additive in the feed is 6.5%~42%, the above-mentioned oral health effect of acquirement It is really best.

Plant additive adds the mode of raw material to be not particularly limited, it is contemplated that is easy to precise and calculates consumption, excellent Selection of land, sequentially adds after the plant extracts in plant additive is weighed.

In the present embodiment, the species of oral care product is not particularly limited, it is contemplated that the product of preparation needs utilization rate It is higher, preferably by toothpaste, mouthwash and mouthspray.

When oral care product is toothpaste, the creative experiment of inventor show that by mass percentage, raw material includes： 0.5%~5% green-tea extract, 2.5%~5% mint extract, 1.2%~2% emblic extract, 0.5% ~5% licorice, during 0.5%~5% propolis extract, the oral health benefits that it mitigates bleeding gums etc. are most It is good.

When oral care product is mouthwash, the creative experiment of inventor draws, by mass percentage, raw material bag Include：1.5%~3.5% green-tea extract, 0.5%~5% mint extract, 2.5%~3% emblic extract, 1.5%~5% licorice, during 0.5%~5% propolis extract, the effect of the oral health of its fresh breath etc. It is best.

When oral care product is mouthspray, the creative experiment of inventor draws, by mass percentage, raw material bag Include：0.5%~5% green-tea extract, 2.5%~5% mint extract, 1.2%~2% emblic extract, 0.5%~5% licorice, during 0.5%~5% propolis extract, its oral health for repairing oral mucosa etc. Effect is best.

Feature of the invention and performance are described in further detail with reference to embodiments.

Embodiment 1-8

Embodiment 1-8 each provides a kind of bacteriostatic agent and preparation method thereof.

The part formulation of the bacteriostatic agent that embodiment 1-8 is provided is as shown in table 1 below：

Table 1

The preparation method of the bacteriostatic agent that embodiment 1-8 is provided is as follows：

Green tea, peppermint, emblic, Radix Glycyrrhizae and propolis are extracted respectively using water, ethanol by ultrasonic extraction technology, Sound wave extraction design temperature is 15 DEG C, green-tea extract, the mint extract that will be obtained, emblic extract, licorice Mix by above-mentioned weight portion with propolis extract, bacteriostatic agent is obtained.

Embodiment 9-16

Embodiment 9-16 each provides a kind of toothpaste and preparation method thereof.

The part formulation of the toothpaste that embodiment 9-16 is provided is as shown in table 2 below：

Table 2

The preparation method of the toothpaste that embodiment 9-16 is provided is as follows：

By load weighted green-tea extract, mint extract, emblic extract, licorice and propolis extract with Appropriate grinding agent, NMF, adhesion agent, foaming agent, sweetener, essence and other compositions (preservative, pigment, water, work( Effect additive etc.) conventionally it is made toothpaste.

Embodiment 17-24

Embodiment 17-24 each provides a kind of mouthwash and preparation method thereof.

The part formulation of the mouthwash that embodiment 17-24 is provided is as shown in table 3 below：

Table 3

The preparation method of the mouthwash that embodiment 17-24 is provided is as follows：

By load weighted green-tea extract, mint extract, emblic extract, licorice and propolis extract with Appropriate NMF, emulsifying agent, sweetener, essence and other compositions (preservative, pigment, water, functional additive etc.) according to Conventional method is made mouthwash.

Embodiment 25-32

Embodiment 25-32 each provides a kind of mouthspray and preparation method thereof.

The part formulation of the mouthspray that embodiment 25-32 is provided is as shown in table 4 below：

Table 4

The preparation method of the mouthspray that embodiment 25-32 is provided is as follows：

By load weighted green-tea extract, mint extract, emblic extract, licorice and propolis extract with Appropriate NMF, emulsifying agent, flavor enhancement, ethanol, sweetener, essence and other compositions (preservative, pigment, water, effect Additive etc.) conventionally it is made mouthspray.

Experimental example 1

(1) bacteriostatic agent kills effect to Escherichia coli

16 LB culture mediums are taken, the bacteriostatic agent that the embodiment 1-8 of equivalent prepares are taken and is put into wherein 8 culture mediums, Experimental group 1-8 is provided accordingly to, remaining 8 culture mediums are set to control group 1-8 as a control group；Respectively to experimental group 1- Escherichia coli are added in 8 and control group 1-8, total plate count situation in each culture medium is observed after 8 hours, be shown in Table 5.

(2) bacteriostatic agent kills effect to staphylococcus aureus

16 LB culture mediums are taken, the bacteriostatic agent that the embodiment 1-8 of equivalent prepares are taken and is put into wherein 3 culture mediums, Experimental group 1-8 is provided accordingly to, remaining 8 culture mediums are set to control group 1-8 as a control group；Respectively to experimental group 1- Staphylococcus aureus is added in 8 and control group 1-8, total plate count situation in each culture medium is observed after 8 hours, be shown in Table 5.

Table 5

From data in table 5, the bacteriostatic agent that embodiment 1-8 is prepared shows to Escherichia coli and staphylococcus Significant killing effect, this shows, at least more than three kinds of plant extracts mutual cooperation energy provided in an embodiment of the present invention Enough play a part of Synergistic and kill bacterium jointly.Wherein, wherein, to Escherichia coli and staphylococcic in embodiment 4-6 Insect killing effect is better than embodiment 1-3, and this shows, five Plant Extracts cooperate and can play optimal Synergistic biocidal Effect, its sterilizing ability is better than only three kinds or Four Plants extract collective effect；To Escherichia coli and Portugal in embodiment 4-6 The insect killing effect of grape coccus is better than EXAMPLE Example 7-8, and this shows, in the data model that embodiment of the present invention creativeness is obtained The bactericidal effect for enclosing the bacteriostatic agent of interior preparation is best.

Experimental example 2

Effect of the toothpaste provided in an embodiment of the present invention to improvement bleeding gums

From the similar subject of 90 dental healths, it is divided into 9 groups, every group of 10 people；Embodiment 9-16 is provided Toothpaste (as experimental group 1-8), is carried out with the toothpaste (as a control group 1) without any functional component as together with reference substance Clinical verification；Compare using 9 groups of average bleeding gums index BOP% of subject after same time, be shown in Table 6.

Table 6

From data in table 6, the BOP% values of the subject of experimental group 1-8 behind one month and three months have compared with Be it is obvious decline, and be significantly better than that control group 1, this shows, due to the addition of at least more than three kinds of the present invention in toothpaste The plant extracts that embodiment is provided can improve the improvement efficiency of bleeding gums.Wherein, the subject of experimental group 4-6 is at one The moon and the BOP% after three months are worth down ratio to be more than experimental group 1-3, and this shows compared to addition three kinds and four kinds of present invention The plant extracts that embodiment is improved, five Plant Extracts of addition are better able to comprehensively improve bleeding gums symptom；Experiment BOP% of the subject of group 5 behind one month and three months is worth down ratio to be more than experimental group 4 and experimental group 6, and this shows, When the effect of the improvement bleeding gums that the total addition level of five Plant Extracts is 6.5%~42% is best；Experimental group 4-6's receives BOP% of the examination person behind one month and three months is worth down ratio to be more than experimental group 7-8, and this shows, implements according to the present invention The ratio range of the creative plant extracts for obtaining of example is added in toothpaste, and the effect that it improves bleeding gums is best.

Experimental example 3

Mouthwash provided in an embodiment of the present invention offsets the effect of removing abnormal flavor in oral cavity

There is same degree implication patient from 90, be divided into 9 groups, every group of 10 people；By gargling that embodiment 17-24 is provided Water (as experimental group 1-8), is carried out with the mouthwash (as a control group 1) without any functional component as together with reference substance Experiment；Compare improves situation using 9 groups of implications of patient after same time, is shown in Table 7.

Table 7

From data in table 6, the implication patient of experimental group 1-8 implication degree after two weeks has obtained significantly changing Kind, implication disappears after one month, and control group 1 implication does not still disappear after one month, this shows, due to adding in mouthwash Having added at least more than three kinds of plant extracts provided in an embodiment of the present invention can be obviously improved oral environment, eliminate peculiar smell. Wherein, the patient of experimental group 4-6 after one month compared with experimental group 1-3 implication disappearance on the basis of, implication is apparent from, this table The bright plant extracts improved compared to three kinds and four kinds embodiment of the present invention of addition, five Plant Extracts of addition improve oral cavity Environment, eliminate peculiar smell effect it is more preferable；The implication patient of experimental group 4-6 implication after one month is compared with experimental group 7-8 in implication On the basis of disappearance, implication is apparent from, and this shows, the proportioning of the plant extracts obtained according to embodiment of the present invention creativeness Scope is added in mouthwash, its improve oral environment, eliminate peculiar smell effect it is more preferable.

Experimental example 4

Mouthspray provided in an embodiment of the present invention offsets the effect for repairing oral mucosa

From 90 patients that there is same degree mucous membrane of mouth to fester, it is divided into 9 groups, every group of 10 people；By embodiment 25-32 The mouthspray (as experimental group 1-8) of offer, with mouthspray (as a control group 1) conduct without any functional component Reference substance is tested together；Compare and repair situation using 9 groups of mucous membrane of mouth of patient after same time, be shown in Table 8.

Table 8

From data in table 8, the oral lesions patient of experimental group 1-8 oral lesions degree after two weeks has obtained bright Aobvious improvement even disappears, and control group 1 oral lesions degree still will more be planted after two weeks, this shows, in mouthspray The part festered can have substantially been repaired due to the addition of at least more than three kinds of plant extracts provided in an embodiment of the present invention. Wherein, the patient of experimental group 4-6 after two weeks oral lesions repair degree be better than experimental group 1-3, this show compared to addition three Plant and four kinds of plant extracts of embodiment of the present invention raising, add the synergy of five Plant Extracts more, Neng Gouxian Write and repair oral lesions；Oral lesions repair degree better than experimental group 7-8 to the oral lesions patient of experimental group 4-6 after two weeks, This shows that the ratio range of the plant extracts obtained according to embodiment of the present invention creativeness is added in mouthspray, and it is repaiied The effect of multiple oral lesions is more preferable.

In sum, the bacteriostatic agent as obtained in plant composition provided in an embodiment of the present invention has good antibacterial sterilizing Ability；Oral care product is obtained as additive by plant composition provided in an embodiment of the present invention has excellent mitigation tooth Oulorrhagia, oral mucosa, fresh breath are repaired, eliminate effect of peculiar smell etc., be both adapted to occurring being used when oral cavity goes wrong, It also is adapted for preventing to use in daily life.

Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.Reality of the invention The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of selected implementation of the invention Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made Every other embodiment, belongs to the scope of protection of the invention.