CN109430253A - A kind of Perfused isolated heart system that binary channels holocentric is dirty - Google Patents
- ️Fri Mar 08 2019
Info
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Publication number
- CN109430253A CN109430253A CN201910015974.XA CN201910015974A CN109430253A CN 109430253 A CN109430253 A CN 109430253A CN 201910015974 A CN201910015974 A CN 201910015974A CN 109430253 A CN109430253 A CN 109430253A Authority
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- China Prior art keywords
- mounting substrate
- layer
- heart
- perfusion system
- overflow Prior art date
- 2019-01-08 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 238000009413 insulation Methods 0.000 claims abstract description 19
- 238000004321 preservation Methods 0.000 claims abstract description 18
- 230000010412 perfusion Effects 0.000 claims abstract description 17
- 239000000758 substrate Substances 0.000 claims abstract description 14
- 230000000747 cardiac effect Effects 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 5
- 210000003205 muscle Anatomy 0.000 claims abstract 6
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 claims abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000011521 glass Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims 7
- 241000270295 Serpentes Species 0.000 claims 4
- 230000008676 import Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 24
- 229940079593 drug Drugs 0.000 abstract description 2
- 208000001848 dysentery Diseases 0.000 abstract 1
- 238000009434 installation Methods 0.000 description 22
- 239000000463 material Substances 0.000 description 7
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000007921 spray Substances 0.000 description 4
- 230000002459 sustained effect Effects 0.000 description 4
- 241001468684 Diplocardia Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- BGOFCVIGEYGEOF-UJPOAAIJSA-N helicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UJPOAAIJSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000005488 sandblasting Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/143—Apparatus for organ perfusion
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Devices For Medical Bathing And Washing (AREA)
Abstract
本发明涉及离体心脏灌流领域，具体地，涉及一种双通道单心脏的离体心脏灌流系统，包括安装基板、保温罐、浴腔、肌张组件、针头、两个溢流杯和两个蛇形加热器，两个溢流杯、两个蛇形加热器、保温罐和浴腔沿竖直方向从上而下依次排列设置在安装基板的一侧，肌张组件设置在浴腔的外侧，针头设置在肌张组件的下方，每个蛇形加热器的底部和保温罐的顶部均设有一个鲁尔三通，安装基板的背侧设有储液瓶，每个溢流杯均通过一个药液泵连接至储液瓶，本发明公开的一种双通道单心脏的离体心脏灌流系统，解决了个体性的差异引起数据的不确定性及数据的可比性，同时参与该灌流系统只需要一个心脏，并且更换药物后到达心脏的时间可预见性。The present invention relates to the field of isolated cardiac perfusion, and in particular to a two-channel single-heart ex vivo cardiac perfusion system comprising a mounting substrate, a thermal insulation tank, a bath cavity, a muscle extension assembly, a needle, two overflow cups and two a serpentine heater, two overflow cups, two serpentine heaters, a heat preservation tank and a bath chamber are arranged in a vertical direction from top to bottom on one side of the mounting substrate, and the muscle extension assembly is disposed on the outside of the bath chamber The needle is disposed under the muscle extension assembly, and a Ruhr tee is disposed at the bottom of each serpentine heater and the top of the thermal insulation tank, and a liquid storage bottle is disposed on the back side of the mounting substrate, and each overflow cup passes through A medical fluid pump is connected to the liquid storage bottle, and the invention discloses a two-channel single-heart isolated cardiac perfusion system, which solves the uncertainty of data caused by individual differences and the comparability of data, and participates in the perfusion system. Only one heart is needed, and the time to reach the heart after changing the drug is predictable.
Description
Technical field
The present invention relates to Perfused isolated heart fields, and in particular, to a kind of Perfused isolated heart that binary channels holocentric is dirty System.
Background technique
Perfused isolated heart device is a set of important composition of Perfused isolated heart, and medicine is perfused by peristaltic pump in isolated heart Liquid measures the parameters such as its heart rate and tension, eliminates the interference of nerve and hormone in vivo.Software is cooperated to analyze its each seed ginseng again Number index.Physiology and pathology research to being widely applied.
It a, is at present on the market mainly a kind of single pass Perfused isolated heart device either dirty filling of binary channels diplocardia Stream.Single pass cardiac perfusion device has biggish limitation in terms of the research of physiology and pathology, and the comparison of data becomes tired Difficulty, and cannot determine when that medical fluid reaches heart in midway replacement medical fluid.
B, binary channels diplocardia is dirty while equally existing difficulty in terms of the comparison of data, because being 2 hearts, heart itself It is exactly a variable during experiment, so data have very big uncertainty.The binary channels diplocardia is dirty in perfusion simultaneously 2 hearts must be obtained in the process, and cost undoubtedly improves for experiment.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of Perfused isolated heart system that binary channels holocentric is dirty.
A kind of Perfused isolated heart system that binary channels holocentric is dirty disclosed by the invention, including installation base plate, heat insulation tank, bath Chamber, flesh component, syringe needle, two overflow cups and two snakelike heaters, installation base plate, bath chamber, heat insulation tank and two it is snakelike plus The state setting in a vertical shape of hot device, two snakelike heaters are in sustained height setting, and two overflow cups are set in sustained height It sets, two overflow cups, two snakelike heaters, heat insulation tank and bath chamber are arranged in order at installation from top to down along the vertical direction The outside of bath chamber is arranged in the side of substrate, flesh component, and the lower section of flesh component is arranged in syringe needle, each snakelike heater Rule threeway is equipped at the top of bottom and heat insulation tank, the back side of installation base plate is equipped with liquid storage bottle, and each overflow cup is logical It crosses a spray pump and is connected to liquid storage bottle, the lower section of heat insulation tank is arranged in bath chamber.
Preferably, the bottom of installation base plate is fixedly connected with a horizontally disposed bottom plate, and the back side of installation base plate is symmetrically set There are two strut, the upper and lower side of strut is fixedly connected with installation base plate and bottom plate respectively.
Preferably, installation base plate is equipped with graduation mark along the vertical direction, the upper half of installation base plate and lower half difference The bar shaped adjustment hole for overflow cup and bath intonation section height is used for equipped with several.
Preferably, overflow cup is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet and medical fluid overflow port for being equipped with medical fluid, Outer layer is heat preservation water layer and is equipped with heat preservation water entrance.
Preferably, snakelike heater is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet for being equipped with medical fluid, and outer layer is to protect Warm water layer and be equipped with heat preservation water entrance, snakelike heater body medical fluid layer be equipped with helix tube.
Preferably, heat insulation tank is divided into ectonexine, and internal layer is medical fluid layer and the inlet and outlet for being equipped with medical fluid, and outer layer is heat preservation water Layer and it is equipped with heat preservation water entrance, spiral helicine glass tube is equipped with inside heat insulation tank.
Preferably, bath chamber is the hollow form structure of open upper end, and is equipped with the inlet and outlet of heat preservation water.
The utility model has the advantages that a kind of Perfused isolated heart system that binary channels holocentric is dirty disclosed by the invention, solves individuality Difference cause the uncertainty of data and the comparativity of data, simultaneously participate in the perfusion system and only need a heart, and The time that heart is reached after replacement drug is predictable.
Detailed description of the invention
The drawings described herein are used to provide a further understanding of the present application, constitutes part of this application, this Shen Illustrative embodiments and their description please are not constituted an undue limitation on the present application for explaining the application.In the accompanying drawings:
Fig. 1 is schematic perspective view of the invention；
Fig. 2 is pipeline connecting figure of the invention；
Fig. 3 is the structure chart of first liquid storage bottle；
Fig. 4 is the structure chart of second liquid storage bottle；
Description of symbols: 1- overflow cup, 2- installation base plate, 3- strut, the snakelike heater of 4-, 5- heat insulation tank, 6- bathe chamber, 7- flesh Open component, 8- bottom plate, 9- bar shaped adjustment hole.
Specific embodiment
Multiple embodiments of the invention will be disclosed with schema below, as clearly stated, the details in many practices It will be explained in the following description.It should be appreciated, however, that the details in these practices is not applied to limit the present invention.Also It is to say, in some embodiments of the invention, the details in these practices is non-essential.In addition, for the sake of simplifying schema, Some known usual structures and component will be painted it in the drawings in simply illustrative mode.
In addition, the description for being such as related to " first ", " second " in the present invention is used for description purposes only, not especially censure The meaning of order or cis-position, also non-to limit the present invention, the component described just for the sake of difference with same technique term Or operation, it is not understood to indicate or imply its relative importance or implicitly indicates the number of indicated technical characteristic Amount." first " is defined as a result, the feature of " second " can explicitly or implicitly include at least one of the features.In addition, each Technical solution between a embodiment can be combined with each other, but must can be implemented as base with those of ordinary skill in the art Plinth will be understood that the combination of this technical solution is not present when conflicting or cannot achieve when occurs in the combination of technical solution, Also not the present invention claims protection scope within.
A kind of Perfused isolated heart system that binary channels holocentric is dirty referring to figs. 1 to 4, including installation base plate 2, guarantor Warm tank 5, bath chamber 6, flesh component 7, syringe needle, two overflow cups 1 and two snakelike heaters 4, installation base plate 2, bath chamber 6, heat preservation Tank 5 and the state setting in a vertical shape of two snakelike heaters 4, two snakelike heaters 4 are in sustained height setting, two overflows Cup 1 is arranged in sustained height, and two overflow cups, 1, two snakelike heater 4, heat insulation tank 5 and bath chamber 6 are along the vertical direction from upper The side of installation base plate 2 is arranged in order under and, the outside of bath chamber 6 is arranged in flesh component 7, and syringe needle setting is in flesh group The lower section of part 7, the bottom of each snakelike heater 4 and the top of heat insulation tank 5 are equipped with Rule threeway, installation base plate 2 Back side is equipped with liquid storage bottle, and each overflow cup 1 is connected to liquid storage bottle by a spray pump, and bath chamber 6 is arranged under heat insulation tank 5 Side.
The bottom of installation base plate 2 is fixedly connected with a horizontally disposed bottom plate 8, and the back side of installation base plate 2 is symmetrically arranged with two A strut 3, the upper and lower side of strut 3 are fixedly connected with installation base plate 2 and bottom plate 8 respectively.Bottom plate 8 uses 6061 materials, does sandblasting Sky blue anodized.
Installation base plate 2 is equipped with graduation mark along the vertical direction, if the upper half and lower half of installation base plate 2 are respectively equipped with Dry for adjusting the bar shaped adjustment hole 9 of height for overflow cup 1 and bath chamber 6.Installation base plate 2 is PMMA material, is other each portions The mounting platform of part, and scale is indicated, facilitate accurate positionin height.
Overflow cup 1 uses GG17 material, is divided into ectonexine, and internal layer is medical fluid layer, and inlet and outlet and medical fluid equipped with medical fluid are overflow Head piece, outer layer are heat preservation water layer equipped with heat preservation water entrance, the adjustable height on substrate, adjustable range 0-200mm, Outside dimension φ 50 × 120, inside dimension are φ 30 × 60.
Snakelike heater 4 uses GG17 material, is divided into ectonexine, and internal layer is medical fluid layer, the inlet and outlet equipped with medical fluid, outer layer It is equipped with heat preservation water entrance for heat preservation water layer, for persistently carrying out the pre-heat treatment to perfusate, internal medical fluid layer uses helix tube, Bore is 3-4mm, and spiral number of turns are 8 circles, screw pitch 12mm.
Heat insulation tank 5 uses GG17 material, is divided into ectonexine, and internal layer is medical fluid layer, and the inlet and outlet equipped with medical fluid, outer layer is to protect Warm water layer is equipped with heat preservation water entrance, and inside is spiral helicine glass tube, which is medical fluid pipeline, and glass bore is 3-4mm, Principal security medical fluid flows through road length as far as possible wherein and medical fluid is relatively next small in size, to reach exposure in not used branch Effect after being preheated again after being partially cooled to room temperature in air.
The hollow form structure that chamber 6 is open upper end is bathed, and is equipped with the inlet and outlet of heat preservation water.It bathes chamber 6 and uses GG17 material Heart is placed in during experiment by mobile bath chamber 6 by material, open upper end hollow form, the inlet and outlet equipped with heat preservation water Wherein, to reach heat insulation effect.
Working principle:
It is the road (left side) and the road (right side) of the second perfusion of the first perfusion that two liquid storage bottles are corresponding.
Process is perfused: the A1 in the outlet map interlinking of the outlet A6 spray pump of the entrance access liquid storage bottle memory of spray pump leads to Medical fluid is passed through the overflow port D1 pipeline of overflow cup 1 by the pressure for crossing pump by the medical fluid that it is extra that A2 squeezes into left side 1 internal layer of overflow cup It returns in liquid storage bottle, the internal layer of snakelike heater 4 is flowed by A4, II-F1- of Rule threeway, I-F3 is finally flowed into heat insulation tank 5 Enter onto the syringe needle for hanging with heart；Similarly the road filling process on right side is the same.Rule threeway I must only during perfusion Guarantee smooth the way or all block, two-way cannot be penetrated through, otherwise liquid medicine contamination.
Keep the temperature process: the entire circuit of heat preservation is a concatenated loop checking installation.
The C10 mouth of the outlet access liquid storage bottle of water bath with thermostatic control connects liquid storage bottle and liquid storage bottle by C11, and C12 pipeline connects The outer layer water access port for connecing bath 6 lower end of chamber flows into heat insulation tank 5 and then is divided into two-way by threeway flows into left and right side respectively The outer layer of snakelike heater 4, subsequently into respective overflow cup 1；Water kept the temperature by threeway converged return water bath with thermostatic control, Whole process is a closed loop checking installation.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.
Claims (7)
1.一种双通道单心脏的离体心脏灌流系统，其特征在于：包括安装基板（2）、保温罐（5）、浴腔（6）、肌张组件（7）、针头、两个溢流杯（1）和两个蛇形加热器（4），安装基板（2）、浴腔（6）、保温罐（5）和两个蛇形加热器（4）均呈竖直状态设置，两个蛇形加热器（4）处于同一高度设置，两个溢流杯（1）处于同一高度设置，两个溢流杯（1）、两个蛇形加热器（4）、保温罐（5）和浴腔（6）沿竖直方向从上而下依次排列设置在安装基板（2）的一侧，肌张组件（7）设置在浴腔（6）的外侧，针头设置在肌张组件（7）的下方，每个蛇形加热器（4）的底部和保温罐（5）的顶部均设有一个鲁尔三通，安装基板（2）的背侧设有储液瓶，每个溢流杯（1）均通过一个药液泵连接至储液瓶，浴腔（6）设置在保温罐（5）的下方。A two-channel single-heart ex vivo cardiac perfusion system, comprising: a mounting substrate (2), a thermal insulation tank (5), a bath cavity (6), a muscle extension assembly (7), a needle, and two overflows The flow cup (1) and the two serpent heaters (4), the mounting substrate (2), the bath chamber (6), the heat preservation tank (5), and the two serpent heaters (4) are all arranged in a vertical state. Two serpent heaters (4) are set at the same height, two overflow cups (1) are set at the same height, two overflow cups (1), two serpent heaters (4), and insulated tanks (5) And the bath chamber (6) is arranged in the vertical direction from the top to the bottom on the side of the mounting substrate (2), the muscle extension assembly (7) is disposed outside the bath chamber (6), and the needle is disposed in the muscle assembly Below the (7), the bottom of each serpentine heater (4) and the top of the incubator (5) are provided with a Luer tee, and the back side of the mounting substrate (2) is provided with a liquid storage bottle, each The overflow cup (1) is connected to the liquid storage bottle by a liquid medicine pump, and the bath chamber (6) is disposed below the heat preservation tank (5). 2.根据权利要求1所述的一种双通道单心脏的离体心脏灌流系统，其特征在于：安装基板（2）的底部固定连接一个水平设置的底板（8），安装基板（2）的背侧对称设有两个支杆（3），支杆（3）的上下端分别与安装基板（2）和底板（8）固定连接。2 . The dual-channel single-heart isolated cardiac perfusion system according to claim 1 , wherein the bottom of the mounting substrate ( 2 ) is fixedly connected to a horizontally disposed bottom plate ( 8 ), and the mounting substrate ( 2 ) Two struts (3) are symmetrically arranged on the back side, and the upper and lower ends of the struts (3) are fixedly connected to the mounting substrate (2) and the bottom plate (8), respectively. 3.根据权利要求1所述的一种双通道单心脏的离体心脏灌流系统，其特征在于：安装基板（2）上设有沿竖直方向的刻度线，安装基板（2）的上半部和下半部分别设有若干个用于供溢流杯（1）和浴腔（6）调节高度的条形调节孔（9）。3 . The dual-channel single-heart isolated cardiac perfusion system according to claim 1 , wherein the mounting substrate ( 2 ) is provided with a vertical line in a vertical direction, and the upper part of the mounting substrate ( 2 ) is mounted. The strip and the lower half are respectively provided with a plurality of strip-shaped adjusting holes (9) for adjusting the height of the overflow cup (1) and the bath chamber (6). 4.根据权利要求1所述的一种双通道单心脏的离体心脏灌流系统，其特征在于：溢流杯（1）分为内外层，内层为药液层并且设有药液的进出口和药液溢流口，外层为保温水层并且设有保温水出入口。4. A two-channel, single-heart, isolated cardiac perfusion system according to claim 1, wherein the overflow cup (1) is divided into an inner and outer layer, and the inner layer is a liquid chemical layer and is provided with a chemical liquid. The outlet and the chemical liquid overflow port, the outer layer is an insulated water layer and is provided with a heat insulating water inlet and outlet. 5.根据权利要求1所述的一种双通道单心脏的离体心脏灌流系统，其特征在于：蛇形加热器（4）分为内外层，内层为药液层并且设有药液的进出口，外层为保温水层并且设有保温水出入口，蛇形加热器（4）内部药液层设有螺旋管。The dual-channel single-heart isolated cardiac perfusion system according to claim 1, wherein the serpentine heater (4) is divided into an inner and outer layer, and the inner layer is a chemical liquid layer and is provided with a chemical liquid. Import and export, the outer layer is a water-insulating water layer and has a heat-insulating water inlet and outlet. The inner layer of the snake-shaped heater (4) is provided with a spiral tube. 6.根据权利要求1所述的一种双通道单心脏的离体心脏灌流系统，其特征在于：保温罐（5）分为内外层，内层为药液层并且设有药液的进出口，外层为保温水层并且设有保温水出入口，保温罐（5）内部设有螺旋状的玻璃管。6 . The dual-channel single-heart isolated cardiac perfusion system according to claim 1 , wherein the thermal insulation tank ( 5 ) is divided into an inner and outer layer, the inner layer is a chemical liquid layer and the chemical liquid is provided with an inlet and outlet. 6 . The outer layer is a heat-insulating water layer and is provided with a heat-insulating water inlet and outlet, and the heat-insulating tank (5) is provided with a spiral glass tube inside. 7.根据权利要求1所述的一种双通道单心脏的离体心脏灌流系统，其特征在于：浴腔（6）为上端敞开的中空形式结构，并且设有保温水的进出口。7. A two-channel, single-cardiac excised cardiac perfusion system according to claim 1, wherein the bath chamber (6) is a hollow form structure with an open upper end and an inlet and outlet for insulating water.
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