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CN110384571A - A kind of large segmental bone defect implantation material and preparation method thereof - Google Patents

  • ️Tue Oct 29 2019
A kind of large segmental bone defect implantation material and preparation method thereof Download PDF

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Publication number
CN110384571A
CN110384571A CN201910769716.0A CN201910769716A CN110384571A CN 110384571 A CN110384571 A CN 110384571A CN 201910769716 A CN201910769716 A CN 201910769716A CN 110384571 A CN110384571 A CN 110384571A Authority
CN
China
Prior art keywords
fixed plate
bone defect
implantation material
receiving part
fixing
Prior art date
2019-08-20
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Pending
Application number
CN201910769716.0A
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Chinese (zh)
Inventor
闫星辰
刘敏
马文有
高硕洪
廖汉林
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Guangdong Institute of New Materials
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Guangdong Institute of New Materials
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2019-08-20
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2019-08-20
Publication date
2019-10-29
2019-08-20 Application filed by Guangdong Institute of New Materials filed Critical Guangdong Institute of New Materials
2019-08-20 Priority to CN201910769716.0A priority Critical patent/CN110384571A/en
2019-10-29 Publication of CN110384571A publication Critical patent/CN110384571A/en
Status Pending legal-status Critical Current

Links

  • 210000000988 bone and bone Anatomy 0.000 title claims abstract description 89
  • 230000007547 defect Effects 0.000 title claims abstract description 71
  • 238000002360 preparation method Methods 0.000 title claims abstract description 12
  • 239000000463 material Substances 0.000 title claims description 25
  • 238000002513 implantation Methods 0.000 title claims description 24
  • 239000007943 implant Substances 0.000 claims abstract description 54
  • 238000000034 method Methods 0.000 claims description 11
  • 238000010146 3D printing Methods 0.000 claims description 4
  • 229910001362 Ta alloys Inorganic materials 0.000 claims description 4
  • 229910001069 Ti alloy Inorganic materials 0.000 claims description 4
  • RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
  • 230000002950 deficient Effects 0.000 claims description 4
  • 238000013461 design Methods 0.000 claims description 4
  • 238000007639 printing Methods 0.000 claims description 4
  • 239000010935 stainless steel Substances 0.000 claims description 4
  • 229910001220 stainless steel Inorganic materials 0.000 claims description 4
  • 229910052715 tantalum Inorganic materials 0.000 claims description 4
  • GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
  • 229910052719 titanium Inorganic materials 0.000 claims description 4
  • 239000010936 titanium Substances 0.000 claims description 4
  • 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
  • 239000003462 bioceramic Substances 0.000 claims description 3
  • 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
  • 238000002844 melting Methods 0.000 claims description 3
  • 230000008018 melting Effects 0.000 claims description 3
  • XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
  • 229920002530 polyetherether ketone Polymers 0.000 claims description 3
  • 238000000465 moulding Methods 0.000 claims description 2
  • 238000007493 shaping process Methods 0.000 claims 2
  • 238000000547 structure data Methods 0.000 claims 1
  • 230000007774 longterm Effects 0.000 abstract description 4
  • 238000009434 installation Methods 0.000 abstract description 3
  • 238000011900 installation process Methods 0.000 abstract description 3
  • 230000003592 biomimetic effect Effects 0.000 description 8
  • 241000282472 Canis lupus familiaris Species 0.000 description 7
  • 238000005516 engineering process Methods 0.000 description 5
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  • 230000000735 allogeneic effect Effects 0.000 description 1
  • 230000009286 beneficial effect Effects 0.000 description 1
  • 239000008280 blood Substances 0.000 description 1
  • 210000004369 blood Anatomy 0.000 description 1
  • 210000002449 bone cell Anatomy 0.000 description 1
  • 239000002639 bone cement Substances 0.000 description 1
  • 230000010261 cell growth Effects 0.000 description 1
  • 239000000919 ceramic Substances 0.000 description 1
  • 238000004891 communication Methods 0.000 description 1
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/307—Prostheses for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/3097—Designing or manufacturing processes using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

本发明提供了一种大段骨缺损植入物及其制备方法，涉及假体技术领域。大段骨缺损植入物包括用于植入缺损部位的承重部、用于与承重部一端的真骨固定的第一固定件和用于与承重部另一端的真骨固定的第二固定件，承重部的一端与第一固定件相连，承重部的另一端与第二固定件相连，第一固定件和第二固定件上均设置有固定孔。在安装过程中将承重部镶嵌入缺损处，并利用两端的固定孔与真骨进行固定，安装方便，且能够达到长期稳定固定的效果。大段骨缺损植入物的制备方法是根据缺损骨的形态，制备符合上述大段骨缺损植入物结构的产品，使制备得到的植入物安装方便，降低了手术的操作难度。

The invention provides a large-segment bone defect implant and a preparation method thereof, and relates to the technical field of prostheses. The large-segment bone defect implant includes a load-bearing part for implanting in the defect site, a first fixing part for fixing to the real bone at one end of the bearing part, and a second fixing part for fixing to the real bone at the other end of the bearing part , one end of the bearing part is connected with the first fixing part, and the other end of the bearing part is connected with the second fixing part, and both the first fixing part and the second fixing part are provided with fixing holes. In the installation process, the load-bearing part is embedded in the defect, and the fixing holes at both ends are used to fix it with the real bone, which is convenient for installation and can achieve long-term stable fixation. The preparation method of the large-segment bone defect implant is to prepare a product conforming to the structure of the above-mentioned large-segment bone defect implant according to the shape of the defect bone, which makes the prepared implant easy to install and reduces the operation difficulty of the operation.

Description

一种大段骨缺损植入物及其制备方法Implant for large segmental bone defect and preparation method thereof

技术领域technical field

本发明涉及假体技术领域，具体而言，涉及一种大段骨缺损植入物及其制备方法。The invention relates to the technical field of prostheses, in particular to a large-segment bone defect implant and a preparation method thereof.

背景技术Background technique

随着人们生活水平的不断提高，越来越多的人们喜欢饲养宠物，特别是猫、犬类宠物，根据《2018年中国宠物行业白皮书》的数据统计可知，2018年中国宠物(犬猫)消费市场规模达到1708亿，同比增长27％。但是，《白皮书》显示，宠物服务消费中医疗服务费占比最高，狗主人在宠物医疗上年均花费1557.2元，但宠物主人对医疗服务不满意的比例高达47.1％。宠物因受车辆冲撞或从高处坠落而引起的严重骨折，或因感染、肿瘤等引起的大段骨缺损需要进行骨植入。因此，面对日益增长的市场需求，开发用于宠物猫、宠物狗的大段骨缺损植入物是十分有必要的。With the continuous improvement of people's living standards, more and more people like to keep pets, especially cats and dogs. According to the statistics of the "2018 White Paper on China's Pet Industry", the consumption of pets (dogs and cats) in China in 2018 The market size reached 170.8 billion, a year-on-year increase of 27%. However, the "White Paper" shows that medical service fees account for the highest proportion of pet service consumption. Dog owners spend an average of 1557.2 yuan per year on pet medical treatment, but the proportion of pet owners who are dissatisfied with medical services is as high as 47.1%. Bone implantation is required for severe fractures caused by pets being hit by vehicles or falling from heights, or large bone defects caused by infection and tumors. Therefore, in the face of increasing market demand, it is very necessary to develop large bone defect implants for pet cats and pet dogs.

一般大于2cm的大段骨缺损则无法自行愈合，需要进行手术治疗，也即需要进行人工骨植入治疗。众所周知，临床上利用异体骨是骨移植及骨植入采用最多的办法，但由于其来源有限且有可能导致植入部位的感染及坏死，导致治疗不成功。Generally, large bone defects larger than 2 cm cannot heal on their own and require surgical treatment, that is, artificial bone implantation. As we all know, the clinical use of allogeneic bone is the most widely used method of bone transplantation and bone implantation, but due to its limited source and the possibility of infection and necrosis at the implantation site, the treatment is unsuccessful.

目前，应用于人体的大段骨缺损植入物主要有骨水泥及陶瓷等植入物，但应用于犬类的植入物的报道还较少，且其固定办法多采用增加额外固定结构进行固定，这使得植入手术的复杂程度增加。At present, implants for large bone defects used in humans mainly include bone cement and ceramic implants, but there are few reports on implants used in dogs, and the fixation method is mostly to add additional fixation structures. Fixed, which increases the complexity of implant surgery.

发明内容Contents of the invention

本发明的目的在于提供一种大段骨缺损植入物，旨在使植入物安装方便，并使植入物可以长期稳定的进行固定。The purpose of the present invention is to provide a large bone defect implant, aiming at making the implant easy to install and enabling the implant to be fixed stably for a long time.

本发明的另一目的在于提供一种大段骨缺损植入物的制备方法，其制备得到的植入物结构简单、安装方便，降低了手术操作的复杂程度。Another object of the present invention is to provide a method for preparing a large-segment bone defect implant. The prepared implant has a simple structure, is easy to install, and reduces the complexity of operation.

本发明是这样实现的：The present invention is achieved like this:

本发明提供一种大段骨缺损植入物，包括用于植入缺损部位的承重部、用于与承重部一端的真骨固定的第一固定件和用于与承重部另一端的真骨固定的第二固定件，承重部的一端与第一固定件相连，承重部的另一端与第二固定件相连，第一固定件和第二固定件上均设置有固定孔。The present invention provides a large-segment bone defect implant, which comprises a load-bearing part for implanting in the defect site, a first fixing part for fixing with the real bone at one end of the load-bearing part, and a first fixing part for fixing with the real bone at the other end of the load-bearing part. As for the fixed second fixing part, one end of the bearing part is connected with the first fixing part, and the other end of the bearing part is connected with the second fixing part, and both the first fixing part and the second fixing part are provided with fixing holes.

进一步地，在本发明较佳的实施例中，承重部为空心筒状，且承重部呈多孔结构。Further, in a preferred embodiment of the present invention, the load-bearing part is in the shape of a hollow cylinder, and the load-bearing part has a porous structure.

进一步地，在本发明较佳的实施例中，承重部上的孔为正六边形孔，正六边形孔的孔径为500-600μm。Further, in a preferred embodiment of the present invention, the holes on the bearing part are regular hexagonal holes, and the diameter of the regular hexagonal holes is 500-600 μm.

进一步地，在本发明较佳的实施例中，第一固定件包括连接于承重部一侧的第一固定板和与第一固定板相对的第二固定板，第一固定板和第二固定板上均设置有至少一个固定孔。Further, in a preferred embodiment of the present invention, the first fixing member includes a first fixing plate connected to one side of the bearing part and a second fixing plate opposite to the first fixing plate, the first fixing plate and the second fixing plate Each plate is provided with at least one fixing hole.

进一步地，在本发明较佳的实施例中，第二固定件包括连接于承重部一侧的第三固定板和与第三固定板相对的第四固定板，第三固定板和第三固定板上均设置有至少一个固定孔。Further, in a preferred embodiment of the present invention, the second fixing member includes a third fixing plate connected to one side of the bearing part and a fourth fixing plate opposite to the third fixing plate, the third fixing plate and the third fixing plate Each plate is provided with at least one fixing hole.

进一步地，在本发明较佳的实施例中，第一固定板、第二固定板、第三固定板和第四固定板均为弧形板，且弧度与承重部的端部弧度相一致。Further, in a preferred embodiment of the present invention, the first fixing plate, the second fixing plate, the third fixing plate and the fourth fixing plate are all arc-shaped plates, and the arc is consistent with the end arc of the bearing part.

进一步地，在本发明较佳的实施例中，第一固定板、第二固定板、第三固定板和第四固定板上最远离对应的承重部端部的固定孔与对应的承重部的端部的距离为0.8-1.2cm。Further, in a preferred embodiment of the present invention, the fixing hole on the first fixing plate, the second fixing plate, the third fixing plate and the fourth fixing plate is farthest from the end of the corresponding load-bearing part and the corresponding bearing part The distance between the ends is 0.8-1.2cm.

进一步地，在本发明较佳的实施例中，大段骨缺损植入物的材质选自纯钛、钛合金、纯钽、钽合金、不锈钢、聚醚醚酮和生物陶瓷中的至少一种。Further, in a preferred embodiment of the present invention, the material of the large-segment bone defect implant is selected from at least one of pure titanium, titanium alloy, pure tantalum, tantalum alloy, stainless steel, polyether ether ketone, and bioceramic .

进一步地，在本发明较佳的实施例中，承重部、第一固定件和第二固定件上均设置有仿生层。Further, in a preferred embodiment of the present invention, a biomimetic layer is provided on the bearing part, the first fixing part and the second fixing part.

本发明还提供一种大段骨缺损植入物的制备方法，包括：根据缺损骨的形态，制备出大段骨缺损植入物。The present invention also provides a method for preparing a large-segment bone defect implant, comprising: preparing a large-segment bone defect implant according to the shape of the defect bone.

本发明实施例提供的大段骨缺损植入物的有益效果是：本发明通过上述设计得到的大段骨缺损植入物，其通过在承重部的两端分别设置第一固定件和第二固定件，并在第一固定件和第二固定件上设置便于与真骨进行固定的固定孔，在安装过程中将承重部镶嵌入缺损处，并利用两端的固定孔与真骨进行固定，安装方便，且能够达到长期稳定固定的效果。The beneficial effect of the large-segment bone defect implant provided by the embodiment of the present invention is: the large-segment bone defect implant obtained through the above-mentioned design of the present invention, it is provided with the first fixing member and the second fixing member at the two ends of the load-bearing part respectively. Fixing parts, and set fixing holes on the first fixing part and the second fixing part to facilitate fixing with the real bone. During the installation process, insert the load-bearing part into the defect, and use the fixing holes at both ends to fix with the real bone. The installation is convenient, and the effect of long-term stable fixing can be achieved.

本发明实施例还提供了一种大段骨缺损植入物的制备方法，其根据缺损骨的形态，制备符合上述大段骨缺损植入物结构的产品，使制备得到的植入物安装方便，降低了手术的操作难度。The embodiment of the present invention also provides a preparation method of a large-segment bone defect implant, which prepares a product conforming to the structure of the above-mentioned large-segment bone defect implant according to the shape of the defect bone, so that the prepared implant is easy to install , reducing the difficulty of the operation.

附图说明Description of drawings

为了更清楚地说明本发明实施方式的技术方案，下面将对实施方式中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本发明的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention, and therefore do not It should be regarded as a limitation on the scope, and those skilled in the art can also obtain other related drawings based on these drawings without creative work.

图1是本发明实施方式提供的大段骨缺损植入物的第一视角结构示意图；Fig. 1 is a schematic view of the structure of a large bone defect implant provided by an embodiment of the present invention from a first perspective;

图2是本发明实施方式提供的大段骨缺损植入物的第二视角结构示意图；Fig. 2 is a schematic structural diagram of a second perspective view of a large-segment bone defect implant provided by an embodiment of the present invention;

图3是本发明实施方式提供的大段骨缺损植入物的第三视角结构示意图；Fig. 3 is a schematic structural diagram of a third perspective view of a large-segment bone defect implant provided by an embodiment of the present invention;

图4是图1中Ⅳ区的放大图。Fig. 4 is an enlarged view of area IV in Fig. 1 .

图标：100-大段骨缺损植入物；101-固定孔；110-承重部；120-第一固定件；121-第一固定板；122-第二固定板；130-第二固定件；131-第三固定板；132-第四固定板。Icons: 100-large segmental bone defect implant; 101-fixation hole; 110-load-bearing part; 120-first fixing piece; 121-first fixing plate; 122-second fixing plate; 130-second fixing piece; 131 - the third fixed plate; 132 - the fourth fixed plate.

具体实施方式Detailed ways

为使本发明实施方式的目的、技术方案和优点更加清楚，下面将结合本发明实施方式中的附图，对本发明实施方式中的技术方案进行清楚、完整地描述，显然，所描述的实施方式是本发明一部分实施方式，而不是全部的实施方式。基于本发明中的实施方式，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施方式，都属于本发明保护的范围。因此，以下对在附图中提供的本发明的实施方式的详细描述并非旨在限制要求保护的本发明的范围，而是仅仅表示本发明的选定实施方式。基于本发明中的实施方式，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施方式，都属于本发明保护的范围。In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

在本发明的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的设备或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation indicated by rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc. The positional relationship is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as limiting the invention.

此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本发明的描述中，“多个”的含义是两个或两个以上，除非另有明确具体的限定。In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as "first" and "second" may explicitly or implicitly include one or more of these features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或成一体；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrated; it can be mechanically connected or electrically connected; it can be directly connected or indirectly connected through an intermediary, and it can be the internal communication of two components or the interaction relationship between two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.

在本发明中，除非另有明确的规定和限定，第一特征在第二特征之“上”或之“下”可以包括第一和第二特征直接接触，也可以包括第一和第二特征不是直接接触而是通过它们之间的另外的特征接触。而且，第一特征在第二特征“之上”、“上方”和“上面”包括第一特征在第二特征正上方和斜上方，或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”包括第一特征在第二特征正下方和斜下方，或仅仅表示第一特征水平高度小于第二特征。In the present invention, unless otherwise clearly specified and limited, a first feature being "on" or "under" a second feature may include direct contact between the first and second features, and may also include the first and second features Not in direct contact but through another characteristic contact between them. Moreover, "above", "above" and "above" the first feature on the second feature include that the first feature is directly above and obliquely above the second feature, or simply means that the first feature is horizontally higher than the second feature. "Below", "beneath" and "under" the first feature to the second feature include that the first feature is directly below and obliquely below the second feature, or simply means that the first feature has a lower level than the second feature.

请参照图1-3，本发明实施例提供一种大段骨缺损植入物100，包括用于植入缺损部位的承重部110、用于与承重部110一端的真骨固定的第一固定件120和用于与承重部110另一端的真骨固定的第二固定件130。利用承重部110两端的第一固定件120和第二固定件130与真骨进行固定，从而实现承重部110长久稳定的固定。Referring to Figures 1-3, an embodiment of the present invention provides a large bone defect implant 100, including a load-bearing part 110 for implanting in the defect site, and a first fixation part for fixing to the real bone at one end of the load-bearing part 110. part 120 and the second fixing part 130 for fixing with the real bone at the other end of the load-bearing part 110 . The first fixing member 120 and the second fixing member 130 at both ends of the bearing part 110 are used to fix the real bone, so as to achieve long-term and stable fixing of the bearing part 110 .

具体地，承重部110的一端与第一固定件120相连，承重部110的另一端与第二固定件130相连，第一固定件120和第二固定件130上均设置有固定孔101。第一固定件120和第二固定件130可以与承重部110是一体成型的方式，便于通过3D打印制备形成。在第一固定件120和第二固定件130上均设置固定孔101，便于通过螺钉等固定件进行固定。优选地，固定孔101可以为螺纹孔，以加强连接的稳定性。Specifically, one end of the bearing part 110 is connected to the first fixing part 120 , and the other end of the bearing part 110 is connected to the second fixing part 130 , and both the first fixing part 120 and the second fixing part 130 are provided with fixing holes 101 . The first fixing part 120 and the second fixing part 130 can be integrally formed with the bearing part 110 , which is convenient to be prepared and formed by 3D printing. Both the first fixing member 120 and the second fixing member 130 are provided with fixing holes 101, which are convenient for fixing by fixing members such as screws. Preferably, the fixing hole 101 may be a threaded hole to enhance the stability of the connection.

进一步地，承重部110为空心筒状，且承重部110呈多孔结构。筒状并不是严格的圆筒，是与缺损处的骨头形状相适应的类筒状结构。多孔结构的承重部110能够为骨细胞的增殖及生长提供了更好的空间与环境，有效降低植入体的弹性模量的同时也能保证强度，提高了植入相容性，能够减轻或避免植入后与真骨组织的排斥现象。Further, the load-bearing portion 110 is hollow cylindrical, and the load-bearing portion 110 has a porous structure. The cylindrical shape is not strictly a cylinder, but a cylindrical structure that adapts to the shape of the bone in the defect. The load-bearing part 110 with a porous structure can provide a better space and environment for the proliferation and growth of bone cells, effectively reduce the elastic modulus of the implant, and at the same time ensure the strength, improve the implant compatibility, and reduce or Avoid rejection with true bone tissue after implantation.

请结合图1和图4，在本发明较佳的实施例中，承重部110上的孔为正六边形孔，正六边形孔的孔径为500-600μm。正六边形孔具有对称性，相比于一般的孔的形状，受力更加均匀，能够进一步提升植入物的使用寿命。正六边形孔的孔径设置为500-600μm为宜，具体可以根据承重部110的具体大小进行调整。六边形孔的孔径为常规理解，可以为正六边形所在的圆形结构的半径。Please refer to FIG. 1 and FIG. 4 , in a preferred embodiment of the present invention, the holes on the bearing part 110 are regular hexagonal holes, and the diameter of the regular hexagonal holes is 500-600 μm. The regular hexagonal hole has symmetry, and compared with the shape of the general hole, the force is more uniform, which can further improve the service life of the implant. The diameter of the regular hexagonal hole is preferably set at 500-600 μm, which can be adjusted according to the specific size of the bearing part 110 . The aperture of the hexagonal hole is conventionally understood, and may be the radius of the circular structure where the regular hexagon is located.

进一步地，第一固定件120包括连接于承重部110一侧的第一固定板121和与第一固定板121相对的第二固定板122，第一固定板121和第二固定板122上均设置有至少一个固定孔101。在承重部110的两侧均设置固定板，能够增加固定结构的稳定性，通过将第一固定板121和第二固定板122设置为对称的形式，也使整体结构的受力更加均匀。Further, the first fixing member 120 includes a first fixing plate 121 connected to one side of the load-bearing portion 110 and a second fixing plate 122 opposite to the first fixing plate 121, both on the first fixing plate 121 and the second fixing plate 122 are At least one fixing hole 101 is provided. Both sides of the load-bearing part 110 are provided with fixing plates, which can increase the stability of the fixing structure. By arranging the first fixing plate 121 and the second fixing plate 122 in a symmetrical form, the stress of the whole structure is also made more uniform.

同样，第二固定件130包括连接于承重部110一侧的第三固定板131和与第三固定板131相对的第四固定板132，第三固定板131和第三固定板131上均设置有至少一个固定孔101。整体结构呈上下对称、左右对称的形式，受力均匀性更好，固定的稳定性更高，增加了整个植入物的使用寿命。Likewise, the second fixing member 130 includes a third fixing plate 131 connected to one side of the load-bearing portion 110 and a fourth fixing plate 132 opposite to the third fixing plate 131, both of which are arranged on the third fixing plate 131 and the third fixing plate 131. There is at least one fixing hole 101 . The overall structure is in the form of up-down symmetry and left-right symmetry, with better force uniformity, higher fixation stability, and increased service life of the entire implant.

在本发明较佳的实施例中，第一固定板121、第二固定板122、第三固定板131和第四固定板132均为弧形板，且弧度与承重部110的端部弧度相适应，以使第一固定板121、第二固定板122、第三固定板131和第四固定板132的端部边缘与对应的承重部110的端部边缘相贴合。采用弧形过渡的方式，能够减少对血液的影响，增加使用的舒适度。In a preferred embodiment of the present invention, the first fixing plate 121, the second fixing plate 122, the third fixing plate 131 and the fourth fixing plate 132 are all arc-shaped plates, and the radian is the same as that of the end of the load-bearing part 110. Adapt, so that the end edges of the first fixing plate 121 , the second fixing plate 122 , the third fixing plate 131 and the fourth fixing plate 132 are attached to the end edges of the corresponding bearing part 110 . The arc transition method can reduce the impact on the blood and increase the comfort of use.

进一步地，第一固定板121、第二固定板122、第三固定板131和第四固定板132上最远离对应的承重部110端部的固定孔101与对应的承重部110的端部的距离为0.8-1.2cm。固定孔101的个数不限，可以在每个固定板上设置2个固定孔101，以达到更稳定支撑的效果。最远端的固定孔101距离承重部110端部的距离以1cm左右为宜，在此范围内能够更好地固定承重部110，达到更稳固的固定效果。固定孔101在每个固定板上可以均设置2个，沿竖直方向等间距排列。Further, the fixing hole 101 on the first fixing plate 121, the second fixing plate 122, the third fixing plate 131 and the fourth fixing plate 132 farthest from the end of the corresponding bearing part 110 is connected to the end of the corresponding bearing part 110. The distance is 0.8-1.2cm. The number of fixing holes 101 is not limited, and two fixing holes 101 can be provided on each fixing plate to achieve a more stable support effect. The distance between the most distal fixing hole 101 and the end of the load-bearing part 110 is preferably about 1 cm. Within this range, the load-bearing part 110 can be better fixed and a more stable fixing effect can be achieved. Two fixing holes 101 may be provided on each fixing plate, arranged at equal intervals along the vertical direction.

进一步地，大段骨缺损植入物100的材质选自纯钛、钛合金、纯钽、钽合金、不锈钢、聚醚醚酮和生物陶瓷中的至少一种。以上几种现有材质均适合于作为大段骨缺损植入物100的材质，不容易发生排异反应。其中，纯钛、钛合金、纯钽、钽合金和不锈钢的应用更加广泛。Further, the material of the large-segment bone defect implant 100 is selected from at least one of pure titanium, titanium alloy, pure tantalum, tantalum alloy, stainless steel, polyether ether ketone, and bioceramics. The above several existing materials are all suitable as the material of the implant 100 for large segmental bone defects, and are not prone to rejection. Among them, pure titanium, titanium alloy, pure tantalum, tantalum alloy and stainless steel are more widely used.

在本发明较佳的实施例中，承重部110、第一固定件120和第二固定件130上均设置有仿生层，仿生层可以进一步提高植入物的生物相容性。仿生层可以采用微弧氧化(SMAT)、溶胶凝胶、电化学等技术进行处理，使植入物表面获得一层涂层结构，仿生层的材质可以为羟基磷灰石。In a preferred embodiment of the present invention, the load-bearing part 110 , the first fixing part 120 and the second fixing part 130 are all provided with a biomimetic layer, and the biomimetic layer can further improve the biocompatibility of the implant. The biomimetic layer can be treated with micro-arc oxidation (SMAT), sol-gel, electrochemical and other technologies to obtain a coating structure on the surface of the implant, and the material of the biomimetic layer can be hydroxyapatite.

需要补充的是，本发明实施例提供的大段骨缺损植入物100应用于宠物狗植入手术，针对宠物狗大段骨缺损植入手术日益增长的现象，可以改善人们对现有宠物医疗不满的现状，促进宠物医疗的发展。What needs to be added is that the large-segment bone defect implant 100 provided by the embodiment of the present invention is applied to pet dog implantation surgery, which can improve people's understanding of existing pet medical treatment in view of the increasing phenomenon of pet dog large-segment bone defect implantation surgery. Dissatisfaction with the status quo promotes the development of pet medicine.

本发明实施例还提供一种大段骨缺损植入物的制备方法，包括：根据缺损骨的形态，制备出大段骨缺损植入物。根据缺损骨的形态，使承重部与缺损骨的形态相适应，通过现有技术制备大段骨缺损植入物。The embodiment of the present invention also provides a method for preparing a large-segment bone defect implant, comprising: preparing a large-segment bone defect implant according to the shape of the defect bone. According to the shape of the defect bone, the load-bearing part is adapted to the shape of the defect bone, and a large-segment bone defect implant is prepared through the prior art.

优选地，大段骨缺损植入物的制备采用3D打印技术一次性打印成型，减少了复杂繁琐的加工过程，有效地节约了成本。Preferably, the preparation of the large-segment bone defect implant adopts 3D printing technology to print and shape at one time, which reduces the complicated and cumbersome processing process and effectively saves the cost.

具体地，大段骨缺损植入物的制备过程包括：采集缺损骨的原始结构数据，根据原始结构数据进行结构设计形成植入物的三维模型；将得到的三维模型导入3D激光熔融设备的控制端，一次性打印成型。其中，采集缺损骨的原始结构数据可以采用三维CT扫描的方式，可以采用Magics等软件设计出大小和形状均与原始缺损骨相吻合的植入物三维模型，承重部和固定件的弧度均需要根据原始缺损骨的弧度进行优化设置，使其与原始骨相贴合。承重部上孔的形状、大小，参照关于大段骨缺损植入物结构的介绍，在此不做过多赘述。Specifically, the preparation process of a large-segment bone defect implant includes: collecting the original structural data of the defective bone, performing structural design according to the original structural data to form a three-dimensional model of the implant; importing the obtained three-dimensional model into the control of the 3D laser melting equipment End, one-time printing and molding. Among them, 3D CT scanning can be used to collect the original structural data of the defective bone, and software such as Magics can be used to design a 3D model of the implant that matches the size and shape of the original bone defect. The radian of the original defect bone is optimized to fit the original bone. For the shape and size of the hole on the load-bearing part, refer to the introduction of the structure of the implant for large segmental bone defects, and will not repeat it here.

需要说明的是，采用3D激光熔融(SLM)设备进行打印的工艺为现有技术，经分层切片及参数设置后一次性打印成型即可。It should be noted that the printing process using 3D laser melting (SLM) equipment is an existing technology, and it can be printed and formed at one time after layered slicing and parameter setting.

在一些实施例中，大段骨缺损植入物的制备过程还包括：在3D打印成型的植入物表面涂覆仿生层；仿生层的材质可以为羟基磷灰石。仿生层的涂覆工艺可以采用现有技术，如微弧氧化(SMAT)、溶胶凝胶、电化学等技术。In some embodiments, the preparation process of the large-segment bone defect implant further includes: coating a biomimetic layer on the surface of the 3D printed implant; the material of the biomimetic layer may be hydroxyapatite. The coating process of the biomimetic layer can adopt existing technologies, such as micro-arc oxidation (SMAT), sol-gel, electrochemical and other technologies.

综上所述，本发明实施例提供的一种大段骨缺损植入物，通过在承重部的两端分别设置第一固定件和第二固定件，并在第一固定件和第二固定件上设置便于与真骨进行固定的固定孔，在安装过程中将承重部镶嵌入缺损处，并利用两端的固定孔与真骨进行固定，安装方便，且能够达到长期稳定固定的效果。承重部采用多孔结构，多孔结构为细胞的增长提供空间，提高骨传导性及骨整合性，还可以降低弹性模量。To sum up, the embodiment of the present invention provides a large-segment bone defect implant, by setting the first fixing piece and the second fixing piece at the two ends of the load-bearing part respectively, and the first fixing piece and the second fixing piece Fixing holes are set on the part for easy fixation with the real bone. During the installation process, the load-bearing part is inserted into the defect, and the fixing holes at both ends are used for fixing with the real bone. It is easy to install and can achieve long-term stable fixation. The load-bearing part adopts a porous structure, which provides space for cell growth, improves osteoconductivity and osseointegration, and can also reduce the modulus of elasticity.

本发明实施例提供的一种大段骨缺损植入物的制备方法，其根据缺损骨的形态，制备符合上述大段骨缺损植入物结构的产品，使制备得到的植入物安装方便，降低了手术的操作难度。The embodiment of the present invention provides a method for preparing a large-segment bone defect implant, which prepares a product conforming to the structure of the above-mentioned large-segment bone defect implant according to the shape of the defect bone, so that the prepared implant is easy to install, The operation difficulty of the operation is reduced.

以上所述仅为本发明的优选实施方式而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (10)

1. a kind of large segmental bone defect implantation material, which is characterized in that including for being implanted into defect load receiving part, for it is described First fixing piece of the true bone fixation of load receiving part one end and for the second fixed of the true bone fixation with the load receiving part other end Part, one end of the load receiving part are connected with first fixing piece, the other end of the load receiving part and the second fixing piece phase Even, fixation hole is provided on first fixing piece and second fixing piece.

2. large segmental bone defect implantation material according to claim 1, which is characterized in that the load receiving part is hollow tubular, and The load receiving part is in porous structure.

3. large segmental bone defect implantation material according to claim 2, which is characterized in that the hole on the load receiving part is positive six sides Shape hole, the aperture of the hexagonal hole are 500-600 μm.

4. large segmental bone defect implantation material according to claim 2, which is characterized in that first fixing piece includes being connected to First fixed plate of the load receiving part side and second fixed plate opposite with first fixed plate, first fixed plate and At least one fixation hole is provided in second fixed plate.

5. large segmental bone defect implantation material according to claim 4, which is characterized in that second fixing piece includes being connected to The third fixed plate of the load receiving part side and fourth fixed plate opposite with the third fixed plate, the third fixed plate and At least one fixation hole is provided in the third fixed plate.

6. large segmental bone defect implantation material according to claim 5, which is characterized in that first fixed plate, described second Fixed plate, the third fixed plate and the 4th fixed plate are arc panel, and the end radian of radian and the load receiving part It is consistent.

7. large segmental bone defect implantation material according to claim 5, which is characterized in that first fixed plate, described second In fixed plate, the third fixed plate and the 4th fixed plate farthest away from the corresponding load receiving part end fixation hole with it is right The distance of the end for the load receiving part answered is 0.8-1.2cm.

8. large segmental bone defect implantation material according to claim 1, which is characterized in that the material of the large segmental bone defect implantation material Matter is selected from least one of pure titanium, titanium alloy, pure tantalum, tantalum alloy, stainless steel, polyether-ether-ketone and bioceramic.

9. large segmental bone defect implantation material according to claim 1, which is characterized in that the load receiving part, described first are fixed Bionical layer is provided on part and second fixing piece.

10. the preparation method of large segmental bone defect implantation material described in any one of claim 1-9 characterized by comprising according to The form of defective bone prepares the large segmental bone defect implantation material；

Preferably, the preparation of the large segmental bone defect implantation material uses the disposable printing shaping of 3D printing technique；

Preferably, the preparation process of the large segmental bone defect implantation material includes: to acquire the prototype structure data of defective bone, according to original Beginning structured data carries out structure and designs the threedimensional model to form implantation material；Obtained threedimensional model is imported into 3D laser melting equipment Control terminal, disposable printing shaping；

It is highly preferred that the preparation process of the large segmental bone defect implantation material further include: applied in the molding implant surface of 3D printing Cover bionical layer；

It is further preferred that the material of the bionical layer is hydroxyapatite.

CN201910769716.0A 2019-08-20 2019-08-20 A kind of large segmental bone defect implantation material and preparation method thereof Pending CN110384571A (en)

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