CN112586372A - Mouse metabolism cage - Google Patents
- ️Fri Apr 02 2021
CN112586372A - Mouse metabolism cage - Google Patents
Mouse metabolism cage Download PDFInfo
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Publication number
- CN112586372A CN112586372A CN202011561992.7A CN202011561992A CN112586372A CN 112586372 A CN112586372 A CN 112586372A CN 202011561992 A CN202011561992 A CN 202011561992A CN 112586372 A CN112586372 A CN 112586372A Authority
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- China Prior art keywords
- urine
- plate
- excrement
- valve
- valve port Prior art date
- 2020-12-25 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000004060 metabolic process Effects 0.000 title claims abstract description 16
- 210000002700 urine Anatomy 0.000 claims abstract description 49
- 238000012360 testing method Methods 0.000 claims abstract description 24
- 238000000926 separation method Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 230000002503 metabolic effect Effects 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000007599 discharging Methods 0.000 claims description 6
- 238000009395 breeding Methods 0.000 claims description 4
- 230000001488 breeding effect Effects 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 4
- 230000005611 electricity Effects 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 238000002474 experimental method Methods 0.000 abstract description 20
- 239000002207 metabolite Substances 0.000 abstract description 9
- 238000012544 monitoring process Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 16
- 210000003608 fece Anatomy 0.000 description 16
- 241000699670 Mus sp. Species 0.000 description 6
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 4
- 235000017491 Bambusa tulda Nutrition 0.000 description 4
- 241001330002 Bambuseae Species 0.000 description 4
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 4
- 239000011425 bamboo Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000010171 animal model Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/01—Removal of dung or urine, e.g. from stables
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a mouse metabolism cage which adopts the technical scheme that the mouse metabolism cage comprises a first test tube for collecting urine, a first valve port is arranged, a second test tube for collecting excrement is detachably connected with a second guide tube, the second valve port is arranged, and a timer and a control device for controlling the opening and closing of the first guide tube and the second guide tube are further arranged on a bottom frame. The invention has the following beneficial effects: after the experiment reaches the preset time, the timer sends a signal to the driving device, so that the first valve plate is used for inserting the first valve port to seal the first conduit, the second valve plate is used for inserting the second valve port to seal the second conduit, and metabolites metabolized by the mouse are prevented from being mixed in outside the experiment time, so that the accuracy of the experiment is ensured, the collection of the metabolites metabolized by the mouse within the limited time can be automatically completed, the manual monitoring and operation are not needed, and the experiment efficiency is improved.
Description
Technical Field
The invention relates to an animal metabolism cage, in particular to a mouse metabolism cage.
Background
An animal metabolism cage is a medical scientific research instrument used in the field of clinical medicine, and is mainly used for metabolism detection of small animals. The metabolism cage collects the excrement and urine naturally discharged by the experimental animal by a method of directly collecting urine quantity by using an excrement-urine separation device, and is a specially designed sealed breeding cage for collecting various excreta of the experimental animal. General experiment can go on in the time of injecing, for example 24 hours mouse metabolism detects, needs the laboratory technician to carry out the experiment in the experimental time to avoid the experiment to produce the error, but the laboratory technician undertakes heavy experimental task, can not monitor always, can waste the manual work like this, is unfavorable for raising the efficiency.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the mouse metabolism cage which can automatically collect mouse metabolites within a limited time without manual monitoring, so that the experiment efficiency is improved.
In order to achieve the purpose, the invention provides the following technical scheme: a mouse metabolism cage comprises a chassis, a cage body for breeding mice is installed on the chassis, the bottom of the cage body is a screen plate, a collecting tank is connected below the screen plate, a separating plate for separating urine and excrement is arranged in the collecting tank, a first outlet for discharging the urine is arranged at the bottom of the collecting tank, a first conduit for leading out the urine is connected to the first outlet, a second outlet for discharging the excrement is arranged on the side surface of the collecting tank, a second conduit for leading out the excrement is connected to the second outlet, a first test tube for collecting the urine is detachably connected to the first conduit, a first valve port is arranged at the first conduit, a second test tube for collecting the excrement is detachably connected to the second conduit, a second valve port is arranged at the second conduit, a timer and a control device for controlling the opening and closing of the first conduit and the second conduit are further installed on the chassis, the control device comprises a driving device, the timer is electrically connected with the driving device, a telescopic rod is arranged on the driving device, a connecting plate is connected onto the telescopic rod, a first valve plate and a second valve plate are connected onto the connecting plate, the first valve plate is used for being inserted into the first valve port to seal the first guide pipe, and the second valve plate is used for being inserted into the second valve port to seal the second guide pipe.
The invention is further configured to: the inner wall of the collecting tank is provided with a sensor used for sensing urine and excrement, the sensor is electrically connected with the driving device, when the sensor senses that the urine or the excrement enters the collecting tank, the driving device drives the telescopic rod to move, the first valve plate is driven to be drawn out from the first valve port, the first guide pipe is opened, and the second valve plate is driven to be drawn out from the second valve port, so that the second guide pipe is opened.
The invention is further configured to: still install vibration isolation device on the chassis, vibration isolation device is including the motor, the motor is provided with the output shaft, the output shaft stretches into in the collecting vat, and be connected with the cam, the cam supports and leans on the bottom surface of separator plate, the separator plate slope sets up, and the lower extreme rotates to be connected on the inner wall of collecting vat, the motor is connected with the sensor electricity, when the sensor senses urine or excrement and urine and gets into the collecting vat, the motor starts, make the cam rotate, with the vibration separator plate, with urine and excrement and urine separation, and guide excrement and urine gets into in the second pipe.
The invention is further configured to: be provided with the blotter on the bottom surface of separator plate, the blotter is provided with the spacing groove, and the spacing groove is used for supplying the cam to insert to it is spacing with the cam.
The invention is further configured to: the first valve port is matched with the first valve plate, a first rubber pad for cleaning the top surface of the first valve plate is arranged above the inner side of the first valve port, the second valve port is matched with the second valve plate, and a second rubber pad for cleaning the top surface of the second valve plate is arranged above the inner side of the second valve port.
The invention is further configured to: still be provided with in the second test tube and strain a section of thick bamboo, the nozzle department of straining a section of thick bamboo is provided with and keeps off the ring, keeps off the ring and is used for placing on the top surface of second test tube to it is unsettled at the test tube to make to strain a section of thick bamboo, and the bottom of straining a section of thick bamboo and the bottom of test tube are provided with the clearance, and the clearance is used for holding the excrement after filtering.
The invention is further configured to: the collecting groove is funnel-shaped.
The invention is further configured to: the cage body is provided with a water supply tank and a feed trough, the water supply tank is connected with a control valve, and the control valve is electrically connected with a timer.
In conclusion, the invention has the following beneficial effects: the experimenter puts the mouse into the cage body, and sets the experiment time through the timer. During the set experimental time, urine and feces metabolized by the mice are separated by the separation plate and pass into the first test tube and the second test tube, respectively. After the experiment reaches the preset time, the timer sends a signal to drive arrangement, control drive arrangement drives the telescopic link and stretches out, make first valve plate be used for inserting first valve port, with closed first pipe, the second valve plate is used for inserting the second valve port, with closed second pipe, the metabolite of mouse metabolism play sneaks into outside the avoidance experiment time, with the accuracy of guaranteeing the experiment, and can accomplish the collection of mouse metabolite in the limited time voluntarily, need not artifical control and operation, thereby improve experimental efficiency.
Drawings
FIG. 1 is a schematic perspective view of a mouse metabolic cage;
FIG. 2 is an enlarged view A of FIG. 1;
FIG. 3 is an enlarged view B of FIG. 1;
fig. 4 is an enlarged view of C of fig. 1.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. In which like parts are designated by like reference numerals. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions in the drawings, and the terms "bottom" and "top," "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.
Referring to fig. 1-4, a mouse metabolism cage comprises a base frame 1, a
cage body2 for breeding mice is mounted on the base frame 1, a
net plate21 is arranged at the bottom of the
cage body2, a
collecting tank3 is connected below the
net plate21, a
separating plate31 for separating urine and feces is arranged in the
collecting tank3, a
first outlet32 for discharging urine is arranged at the bottom, the
first outlet32 is connected with a
first conduit321 for leading out urine, a
second outlet33 for discharging feces is arranged on the side surface of the
collecting tank3, the
second outlet33 is connected with a
second conduit331 for leading out feces, the
first conduit321 is detachably connected with a
first test tube322 for collecting urine and is provided with a
first valve port323, the
second conduit331 is detachably connected with a
second test tube332 for collecting feces and is provided with a
second valve port333, a
timer11 and a control device 4 for controlling the opening and closing of the
first conduit321 and the
second conduit331 are further mounted on the base frame 1, the control device 4 comprises a
driving device41, the
timer11 is electrically connected with the
driving device41, an
expansion link42 is arranged on the
driving device41, a connecting
plate43 is connected on the
expansion link42, a
first valve plate44 and a
second valve plate45 are connected on the
connecting plate43, the
first valve plate44 is inserted into the
first valve port323 to close the
first conduit321, and the
second valve plate45 is inserted into the
second valve port333 to close the
second conduit331.
Through the scheme, the experimenter puts the mouse into the
cage body2, and sets experiment time through the
timer11. Urine and feces metabolized by the mice are separated by the
separation plate31 and pass into the
first test tube322 and the
second test tube332, respectively, during the set experimental time. After the experiment reaches the preset time, the
timer11 sends a signal to the
driving device41, and the
driving device41 is controlled to drive the
telescopic rod42 to extend out, so that the
first valve plate44 is inserted into the
first valve port323 to seal the
first conduit321, and the
second valve plate45 is inserted into the
second valve port333 to seal the
second conduit331, so that metabolites metabolized by the mouse are prevented from being mixed outside the experiment time, the accuracy of the experiment is ensured, the collection of the metabolites metabolized by the mouse within the limited time can be automatically completed, the manual monitoring and operation are not needed, and the experiment efficiency is improved.
As a modified embodiment, a
sensor34 for sensing urine and feces is disposed on the inner wall of the
collecting tank3, the
sensor34 is electrically connected to the
driving device41, and when the
sensor34 senses that urine or feces enters the
collecting tank3, the
driving device41 drives the
telescopic rod42 to move, so as to draw the
first valve plate44 out of the
first valve port323, so as to open the
first conduit321, and to draw the
second valve plate45 out of the
second valve port333, so as to open the
second conduit331.
Through above-mentioned scheme, in the experimental time, when
sensor34 did not sense the mouse and had metabolism out urine and excrement and urine,
first pipe321 and
second pipe331 all are in the closed condition to avoid the evaporation of water in excrement and urine or the urine, ensure the integrality of data, ensure to accomplish the experiment accurately. When the
sensor34 senses that the mouse metabolizes urine and feces, the
sensor34 sends a signal to control the
driving device41 to drive the
telescopic rod42 to move, drive the
first valve plate44 to be drawn out from the
first valve port323 to open the
first conduit321, and drive the
second valve plate45 to be drawn out from the
second valve port333 to open the
second conduit331, and after the metabolites are collected, rapidly close the
first conduit321 and the
second conduit331, so that the metabolites can be collected as much as possible, and the accuracy of the experiment can be guaranteed.
As a modified specific embodiment, a
vibration separation device5 is further installed on the chassis 1, the
vibration separation device5 includes a
motor51, the
motor51 is provided with an
output shaft52, the
output shaft52 extends into the
collecting tank3 and is connected with a
cam53, the
cam53 abuts against the bottom surface of the
separation plate31, the
separation plate31 is obliquely arranged, and the lower end of the separation plate is rotatably connected to the inner wall of the
collecting tank3, the
motor51 is electrically connected with a sensor, when the
sensor34 senses that urine or feces enters the
collecting tank3, the
motor51 is started to rotate the
cam53 to vibrate the
separation plate31 to separate the urine from the feces, and the feces are guided into the
second conduit331.
Through above-mentioned scheme, when
sensor34 sensed that urine or excrement and urine got into collecting
vat3,
motor51 started, drive
output shaft52 and rotate for
cam53 rotates thereupon, with
vibration separation plate31, the vibration is favorable to can complete the separation as far as possible with urine and excrement and urine, and can shake excrement and urine, guide excrement and urine along the separator 311 entering
second pipe331 of slope in, in order to accelerate the speed of separation, and make excrement and urine just can get into in
second pipe331 as early as possible, in order to reduce the time that excrement and urine exposes outside, in order to improve the precision of experiment.
As a modified embodiment, a
cushion pad54 is provided on the bottom surface of the
separation plate31, and the
cushion pad54 is provided with a
limiting groove541, and the limiting
groove541 is used for the
cam53 to be inserted to limit the
cam53.
Through the above scheme, the
cushion pad54 is made of elastic material to avoid too severe vibration, and the
cam53 is limited through the
limiting groove541, and the connection between the cam and the cam is maintained to ensure that the
separation plate31 can be vibrated smoothly and continuously.
As a modified embodiment, the
first valve port323 is matched with the
first valve plate44, a
first rubber pad324 for cleaning the top surface of the
first valve plate44 is arranged above the inner side of the
first valve port323, the
second valve port333 is matched with the
second valve plate45, and a
second rubber pad334 for cleaning the top surface of the
second valve plate45 is arranged above the inner side of the
second valve port333.
Through the scheme, in the back and forth movement process of the
first valve plate44, the
first rubber pad324 abuts against the top surface of the
first valve plate44 to clean the top surface of the
first valve plate44, so that urine is prevented from remaining on the
first valve plate44, and the
first valve plate44 is ensured to move smoothly. During the back and forth movement of the
second valve plate45, the
second rubber pad334 abuts against the top surface of the
second valve plate45, cleaning the top surface of the
second valve plate45 to avoid remaining on the top surface of the second valve plate, respectively, and ensuring that the
second valve plate45 can move smoothly.
As a modified embodiment, the
second test tube332 is further provided with a
filter cartridge6, a
stop ring61 is arranged at the mouth of the
filter cartridge6, the
stop ring61 is used for being placed on the top surface of the
second test tube332 so as to suspend the
filter cartridge6 in the test tube, a
gap62 is arranged between the bottom of the
filter cartridge6 and the bottom of the test tube, and the
gap62 is used for accommodating filtered excrement.
By the above solution, the
filter cartridge6 can contain the feces and filter the excess liquid or other excrement contained in the
gap62 to avoid the feces from being contaminated and ensure that the feces can be kept intact.
As a modified embodiment, the
collection trough3 is funnel-shaped.
Through above-mentioned scheme, leak hopper-shaped be convenient for collect the excrement as far as possible, improve the efficiency of collecting.
In a modified embodiment, the
cage body2 is provided with a
water supply tank22 and a
feed tank23, the
water supply tank22 is connected with a
control valve24, and the
control valve24 is electrically connected with the
timer11.
Through the above scheme, the interval of water feeding is set through the
timer11, thereby ensuring that sufficient water can be supplied through the
water supply tank22. And the mice are fed through the
trough23 to simulate the normal living conditions of the mice as much as possible.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (8)
1. The utility model provides a mouse metabolism cage, is including chassis (1), install on chassis (1) and be used for breeding the cage body (2) of mouse, characterized by: the bottom of the cage body (2) is provided with a screen plate (21), a collecting tank (3) is connected below the screen plate, a separating plate (31) for separating urine and excrement is arranged in the collecting tank (3), a first outlet (32) for discharging the urine is arranged at the bottom of the collecting tank, a first conduit (321) for guiding out the urine is connected to the first outlet (32), a second outlet (33) for discharging the excrement is arranged on the side surface of the collecting tank (3), a second conduit (331) for guiding out the excrement is connected to the second outlet (33), a first test tube (322) for collecting the urine is detachably connected to the first conduit (321), a first valve port (323) is arranged, a second test tube (332) for collecting the excrement is detachably connected to the second conduit (331), a second valve port (333) is arranged, a timer (11) and a controller for controlling the first conduit (321) and the second conduit (331) are further arranged on the chassis (1) ) The control device (4) comprises a driving device (41), the timer (11) is electrically connected with the driving device (41), an expansion rod (42) is arranged on the driving device (41), a connecting plate (43) is connected onto the expansion rod (42), a first valve plate (44) and a second valve plate (45) are connected onto the connecting plate (43), the first valve plate (44) is used for being inserted into a first valve port (323) to seal a first guide pipe (321), and the second valve plate (45) is used for being inserted into a second valve port (333) to seal a second guide pipe (331).
2. The mouse metabolic cage of claim 1, wherein: the inner wall of the collecting tank (3) is provided with a sensor (34) for sensing urine and excrement, the sensor (34) is electrically connected with a driving device (41), when the sensor (34) senses that the urine or the excrement enters the collecting tank (3), the driving device (41) drives the telescopic rod (42) to move, the first valve plate (44) is driven to be drawn out from the first valve port (323) to open the first conduit (321), and the second valve plate (45) is driven to be drawn out from the second valve port (333) to open the second conduit (331).
3. The mouse metabolic cage of claim 2, wherein: still install vibration isolation device (5) on chassis (1), vibration isolation device (5) are including motor (51), motor (51) are provided with output shaft (52), output shaft (52) stretch into in collecting vat (3) to be connected with cam (53), cam (53) support and lean on the bottom surface of separation plate (31), separation plate (31) slope sets up, and the lower extreme rotates and connects on the inner wall of collecting vat (3), motor (51) are connected with sensor (34) electricity, and when sensor (34) sensed urine or excrement and urine and got into collecting vat (3), motor (51) started for cam (53) rotate to vibration separation plate (31), with urine and excrement and urine separation to guide excrement and urine to get into in second pipe (331).
4. The mouse metabolic cage of claim 3, wherein: a buffer pad (54) is arranged on the bottom surface of the separating plate (31), a limiting groove (541) is formed in the buffer pad (54), and the limiting groove (541) is used for inserting the cam (53) so as to limit the cam (53).
5. The mouse metabolic cage of claim 4, wherein: the first valve port (323) is matched with the first valve plate (44), a first rubber pad (324) used for cleaning the top surface of the first valve plate (44) is arranged above the inner side of the first valve port (323), the second valve port (333) is matched with the second valve plate (45), and a second rubber pad (334) used for cleaning the top surface of the second valve plate (45) is arranged above the inner side of the second valve port (333).
6. The mouse metabolic cage of claim 5, wherein: a filter cylinder (6) is further arranged in the second test tube (332), a blocking ring (61) is arranged at the opening of the filter cylinder (6), the blocking ring (61) is placed on the top surface of the second test tube (332) so that the filter cylinder (6) is suspended in the test tube, a gap (62) is formed between the bottom of the filter cylinder (6) and the bottom of the test tube, and the gap (62) is used for accommodating filtered excrement.
7. The mouse metabolic cage of claim 6, wherein: the collecting groove (3) is funnel-shaped.
8. The mouse metabolic cage according to any one of claims 1-7, wherein: the cage body (2) is provided with a water supply tank (22) and a feed tank (23), the water supply tank (22) is connected with a control valve (24), and the control valve (24) is electrically connected with a timer (11).
Priority Applications (1)
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CN202011561992.7A CN112586372A (en) | 2020-12-25 | 2020-12-25 | Mouse metabolism cage |
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CN202011561992.7A CN112586372A (en) | 2020-12-25 | 2020-12-25 | Mouse metabolism cage |
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