CN1213299C - Dry type anti-interference test paper for multiterm of urine test - Google Patents

The present invention relates to a piece of anti-interference dry multi-item urine test paper, which comprises a substrate and a test paper block fixedly arranged on the substrate, wherein a pH value test block is fixed to the head of one end of the substrate, a blank block is adjacent to the pH value test block, test paper blocks for other test items are arranged in front or back of the blank block according to self pH values in an ascending or descending sequence, a specific gravity test paper block is also arranged at the other end of the substrate away from the pH value test block. Under the same condition, Since interference among all test blocks of the anti-interference dry multi-item urine test paper of the present invention due to the flow diffusion of fluid to be measured is less than that of a piece of common test paper, the pH values of the two test paper blocks of the present invention are generally less than 3 or even less than 2 or 1.5 for the existing urine test paper for common test items, and therefore, the anti-interference dry multi-item urine test paper of the present invention has the advantages of accurate measuring result and high interference resisting performance; since the structure is simple without additional technology, original equipment can be used for production, and production cost is low.

A kind of jamproof dry multipurpose urine test paper

(1) technical field:

The present invention relates to a kind of in-vitro diagnosis test paper, particularly a kind of jamproof dry multipurpose urine test paper.

(2) background technology:

Utilize dry multipurpose urine test paper bar to carry out quick test and judge health and fitness information for doctor or patient individual to projects such as pH, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, proportion, vitamin C, ketoboidies, leucocyte in the urine.

The dry type urine test paper of being sold on the existing market is generally by substrate, be packed in the pH that (is spaced apart 2 ~ 3 millimeters) on the substrate, blank block, other entry block with any arrangement, as cholerythrin, urobilinogen, red blood cell, protein, nitrite, vitamin C, glucose, leucocyte, proportion, the indicator paper block of ketoboidies etc. is formed, using method is generally test strips is immersed 1-2 second in the body fluid to be measured, when test strips is taken out from the body fluid that soaks unnecessary test solution is sopped up or wipes off, level holds, and puts into the instrument colorimetric or obtains a result at official hour and color mark plate visual colorimetry according to the test paper operation instructions.That the substrate that uses has is colourless, three kinds of black and whites, survey and estimate dual-purpose test paper for machine, and substrate is white preferably.Yet when operation is when taking out test strips from the body fluid that soaks, in any case careful operation all is difficult to prevent the trickling diffusion mutually between each indicator paper block of unnecessary test solution, thereby interference phenomenon such as produce colour contamination, fade, or be difficult to directly the interference phenomenon of the inhibition chemical reaction differentiated from colour contamination, obvious color change such as fade.Although will unnecessary test solution be sopped up or wipe off when all requiring test strips taken out from the body fluid that soaks on operation instructions, and level holds, yet in the clinical examination process, is difficult to guarantee in time up hill and dale unnecessary test solution is sopped up or wipes off.Currently used anti-interference method has following certain methods: the special hydrophobic coating of coating one deck on substrate, unnecessary test solution should not be accumulated, the shortcoming of this scheme is to need extra coating processing procedure, undue hydrophobization can reduce pressure sensitive adhesive double coated stickup performance again, so effect is unsatisfactory.The 2nd, on the full wafer test strips, cover one deck hydrophobicity nylon wire, each piece indicator paper block to be separated fixing, this mode need also can influence the range estimation judgement to color with special equipment and special material behind surface coverage one deck hydrophobicity nylon wire.For addressing the above problem, the applicant had once applied for to Patent Office of the People's Republic of China, application number is 95216522.8, name is called the utility model patent of " a kind of jamming-proof dry multipurpose test paper bar ", this patent be on the substrate between adjacent indicator paper block embedding paste and to be fixed with barrier blocks, the scheme of embodiment one is too loaded down with trivial details, though and the scheme of embodiment two is feasible, also realize the anti-interference of pH indicator paper block, but fully do not realized each other anti-interference of other indicator paper block except that the pH indicator paper block.

(3) summary of the invention:

The purpose of this invention is to provide and a kind ofly under existing production specifications, can prevent effectively on the test strips that a kind of letter disturbed of trickling mutually of each interblock economizes jamming-proof dry multipurpose urine test paper than the simpler province of existing dry multipurpose test paper bar.

This urine test paper carries out ascending order or descending sort according to the pH value difference of the indicator paper block of each test event itself, because the pH value differs minimum between the two adjacent indicator paper blocks, no matter deposits, and also is to use, and all can make its mutual interference minimum.Because pH value test block very easily is subjected to the interference of other indicator paper blocks, should this generally it be arranged at an end termination of substrate, and also itself and other indicator paper block be kept apart with a blank block.

Because the proportion indicator paper block of test urine specific gravity is when the lighter urine of test proportion, the color of specific weight determine piece is very dark, disturb other indicator paper blocks easily, therefore also it can be arranged on the substrate the other end away from pH value indicator paper block, so both can prevent that the proportion indicator paper block from disturbing other indicator paper blocks, can make it farthest again, reduce to its interference minimum pH value indicator paper block apart from pH value test block.

Below for using the pH value list of indicator paper block always:

PH pH value is near neutral, does not have surge capability substantially

Blank pH value is near neutral, does not have surge capability substantially

Cholerythrin pH value is about 1～2, and surge capability is arranged

Urobilinogen pH value is about 1.5～2.5, and surge capability is arranged

Nitrite pH value is about 2～3, and surge capability is arranged

Protein pH value is about 3～4 surge capability

Glucose pH value is about 4～6, and surge capability is arranged

Red blood cell pH value is about 5～7, and surge capability is arranged

Proportion pH value is about 6～8, and surge capability is arranged

Vitamin C pH value is about 7～9 surge capability

Ketoboidies pH value is about 7～9, and surge capability is arranged

Leucocyte pH value is about 8～10, and surge capability is arranged

Can design putting in order of conventional indicator paper block according to above-mentioned tabulation.

Owing to press its pH between each indicator paper block of dry multipurpose urine test paper of this New Anti-interference, according to ascending order or descending sort on substrate, under same condition, the common test paper of interference ratio that causes owing to liquid trickling diffusion to be measured is little, and to the urine test paper of existing general test item, the pH value difference between two indicator paper blocks of the present invention is generally less than 3, even less than 2 or 1.5, therefore, the measurement result of this New Anti-interference dry multipurpose urine test paper is more accurate, and anti-interference is stronger; Embodiment for the proportion indicator paper block being arranged at away from the substrate other end of pH value indicator paper block has reduced the influence of proportion indicator paper block, and its anti-interference is stronger; And because urine test paper is simple in structure, do not need additional process, can use existing equipment production, low production cost.

(4) description of drawings:

The embodiment structural representation that Fig. 1 carries out ascending order or descending sort by pH value size fully for indicator paper block;

Fig. 2 is arranged at the substrate other end away from pH value indicator paper block, the embodiment structural representation that other indicator paper blocks carry out ascending order or descending sort by pH value size for the proportion indicator paper block.

(5) embodiment:

Because the proportion indicator paper block of test urine specific gravity is when the lighter urine of test proportion, the color of proportion indicator paper block is very dark, disturb other indicator paper blocks easily, therefore also it can be arranged on the substrate the other end away from pH value indicator paper block, so both the proportion indicator paper block can have been disturbed other indicator paper blocks and reduce to minimum, can make it farthest again, reduce to its interference minimum pH value indicator paper block apart from pH value test block.

Following table has provided the pH value and the buffering ability of present each indicator paper block of urine test paper conventional sense project.

PH pH value is near neutral, does not have surge capability substantially

Blank pH value is near neutral, does not have surge capability substantially

Cholerythrin pH value is about 1～2, and surge capability is arranged

Urobilinogen pH value is about 1.5～2.5, and surge capability is arranged

Nitrite pH value is about 2～3, and surge capability is arranged

Protein pH value is about 3～4 surge capability

Glucose pH value is about 4～6, and surge capability is arranged

Red blood cell pH value is about 5～7, and surge capability is arranged

Proportion pH value is about 6～8, and surge capability is arranged

Vitamin C pH value is about 7～9 surge capability

Ketoboidies pH value is about 7～9, and surge capability is arranged

Leucocyte pH value is about 8～10, and surge capability is arranged

According to last table, can make the anti-interference urine test paper of following various arrangements.

First kind of embodiment is 8 urine test papers, and its arrangement mode is:

PH, blank, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, ketoboidies

Therefore, 8 urine test papers also can be arranged as follows:

PH, blank, ketoboidies, red blood cell, glucose, protein, nitrite, urobilinogen, cholerythrin

Or: cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, ketoboidies, blank, pH

Or: ketoboidies, red blood cell, glucose, protein, nitrite, urobilinogen, cholerythrin, blank, pH

Have 4 kinds of arrangement modes.

PH, blank, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, proportion, ketoboidies

Present embodiment also has and 84 kinds of arrangement modes that urine test paper is similar.

PH, blank block, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, ketoboidies, proportion indicator paper block;

Or: pH, blank block, ketoboidies, red blood cell, glucose, protein, nitrite, urobilinogen, cholerythrin, proportion indicator paper block;

Or: proportion indicator paper block, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, ketoboidies, blank block, pH;

Or: proportion indicator paper block, ketoboidies, red blood cell, glucose, protein, nitrite, urobilinogen, cholerythrin, blank block, pH;

Present embodiment also has 4 kinds of arrangement modes, and therefore 9 urine test papers have 8 kinds of arrangement modes.

The third embodiment is 10 urine test papers, and this embodiment is to have increased the leucocyte indicator paper block on the basis of 9 urine test papers, and the position of leucocyte indicator paper block is in close proximity to the ketoboidies indicator paper block, and its arrangement mode is:

PH, blank, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, proportion, ketoboidies, leucocyte

Or: pH, blank block, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, ketoboidies, leucocyte, proportion;

And similar to 9 the urine test paper arrangement modes arrangement mode in totally 8 that develops out by above-mentioned two kinds of arrangement modes.

The 4th kind of embodiment is 11 urine test papers, this embodiment is to have increased the vitamin C indicator paper block on the basis of 10 urine test papers, the position of vitamin C indicator paper block is between proportion indicator paper block and ketoboidies indicator paper block, or between red blood cell indicator paper block and the ketoboidies indicator paper block, its arrangement mode is:

PH, blank, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, proportion, vitamin C, ketoboidies, leucocyte

Or: pH, blank block, cholerythrin, urobilinogen, nitrite, protein, glucose, red blood cell, vitamin C, ketoboidies, leucocyte, proportion

And similar to 9 the urine test paper arrangement modes arrangement mode in totally 8 that develops out by above-mentioned two kinds of arrangement modes.