CN1872273A - Medication composition for treating cardiovascular diseases and cerebrovascular disease, and preparation method - Google Patents
- ️Wed Dec 06 2006
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- CN1872273A CN1872273A CNA2006100789677A CN200610078967A CN1872273A CN 1872273 A CN1872273 A CN 1872273A CN A2006100789677 A CNA2006100789677 A CN A2006100789677A CN 200610078967 A CN200610078967 A CN 200610078967A CN 1872273 A CN1872273 A CN 1872273A Authority
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Abstract
A medicinal composition for treating cerebrovascular and cardiovascular diseases is prepared from 33 Chinese-medicinal materials including notoginseng, pilose asiabell root, red sage root, ginseng, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof.
Background technology
Cardiovascular and cerebrovascular disease is meant heart, brain and body tissue's ischemic or hemorrhagic all pathological changes that caused by arteriosclerosis, hypertension.As hyperlipidemia, high blood viscosity, arteriosclerosis, hypertension, myocardial ischemia-anoxemia, angina pectoris.Latent coronary heart disease: myocardial infarction, ischemic hypoxia apoplexy, the sclerosis of main drive arteries and veins or the like.Brought serious body and mind to wreck to the patient, made thousands of patient suffer painful torment.Western medical treatment can not thoroughly be cured at present, cures the symptoms, not the disease with Western medicine.Current society, the crowd who suffers from cardiovascular and cerebrovascular disease is a lot, life in spite of illness, one day seems like a year.The inventor is through clinical and experimental study, and theory of Chinese medical science " monarch " is followed in strictness, and medicine chemical examination, pharmaceutical research through hundreds and thousands of times work out a kind of pharmaceutical composition for the treatment of the various pathological changes of cardiovascular and cerebrovascular vessel.This medicine cost is low, cure the disease fast, the cure rate height.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease.
Another purpose of the present invention is to provide a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease.
The present invention is achieved through the following technical solutions:
Cortex Eucommiae 10-30 weight portion Radix Dipsaci 10-30 weight portion Radix Notoginseng 6-18 weight portion
Rhizoma Drynariae 10-30 weight portion Radix Codonopsis 15-45 weight portion Arillus Longan 7-23 weight portion
Radix Salviae Miltiorrhizae 50-150 weight portion Fructus Schisandrae Chinensis 6-18 weight portion Radix Ginseng 5-15 weight portion
Radix Polygoni Multiflori 15-45 weight portion Cortex Acanthopancis 6-18 weight portion Fructus Chaenomelis 6-18 weight portion
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 1-3 weight portion Rhizoma valerianae latifoliae 30-90 weight portion Radix Astragali 15-45 weight portion
Radix Angelicae Sinensis 7-23 weight portion Semen Strychni 0.4-1.4 weight portion Herba Aristolochiae Mollissimae 10-30 weight portion
Caulis Piperis Kadsurae 10-30 weight portion Cortex erythrinae 10-30 weight portion Asterias amurensis Lutken 10-30 weight portion
Fructus Mori 7-23 weight portion Rhizoma Dioscoreae 15-45 weight portion Fructus Lycii 30-90 weight portion
Sargassum 30-90 weight portion Radix Aconiti 4-14 weight portion Radix Aconiti Kusnezoffii 4-14 weight portion
Agkistrodon 1-3 weight portion Flos Sophorae 50-150 weight portion Folium Ginkgo 150-450 weight portion
Radix Paeoniae Alba 30-90 weight portion Rhizoma Chuanxiong 30-90 weight portion Rhizoma Et Radix Notopterygii 30-90 weight portion
The optimum ratio of pharmaceutical composition of the present invention is:
The Cortex Eucommiae 20 weight portion Radix Dipsacis 20 weight portion Radix Notoginseng 12 weight portions
Rhizoma Drynariae 20 weight portion Radix Codonopsis 30 weight portion Arillus Longans 15 weight portions
Radix Salviae Miltiorrhizae 100 weight portion Fructus Schisandrae Chinensis 12 weight portion Radix Ginsengs 10 weight portions
Radix Polygoni Multiflori 30 weight portion Cortex Acanthopanciss 12 weight portion Fructus Chaenomeliss 12 weight portions
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2 weight portion Rhizoma valerianae latifoliaes 60 weight portion Radix Astragali 30 weight portions
Radix Angelicae Sinensis 15 weight portion Semen Strychnis 0.9 weight portion Herba Aristolochiae Mollissimae 20 weight portions
Caulis Piperis Kadsurae 20 weight portion Cortex erythrinaes 20 weight portion Asterias amurensis Lutkenes 20 weight portions
Fructus Mori 15 weight portion Rhizoma Dioscoreae 30 weight portion Fructus Lycii 60 weight portions
Sargassum 60 weight portion Radix Aconitis 9 weight portion Radix Aconiti Kusnezoffii 9 weight portions
Agkistrodon 2 weight portion Flos Sophoraes 100 weight portion Folium Ginkgos 300 weight portions
The Radix Paeoniae Alba 60 weight portion Rhizoma Chuanxiongs 60 weight portion Rhizoma Et Radix Notopterygiis 60 weight portions
The optimum ratio of pharmaceutical composition of the present invention is:
The Cortex Eucommiae 15 weight portion Radix Dipsacis 25 weight portion Radix Notoginseng 8 weight portions
Rhizoma Drynariae 25 weight portion Radix Codonopsis 20 weight portion Arillus Longans 20 weight portions
Radix Salviae Miltiorrhizae 70 weight portion Fructus Schisandrae Chinensis 15 weight portion Radix Ginsengs 7 weight portions
Radix Polygoni Multiflori 40 weight portion Cortex Acanthopanciss 9 weight portion Fructus Chaenomeliss 15 weight portions
The Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 1.5 weight portion Rhizoma valerianae latifoliaes 80 weight portion Radixs Astragali 20 weight portions
Radix Angelicae Sinensis 20 weight portion Semen Strychnis 0.6 weight portion Herba Aristolochiae Mollissimae 25 weight portions
Caulis Piperis Kadsurae 15 weight portion Cortex erythrinaes 25 weight portion Asterias amurensis Lutkenes 15 weight portions
Fructus Mori 20 weight portion Rhizoma Dioscoreaes 20 weight portion Fructus Lycii 80 weight portions
Sargassum 40 weight portion Radix Aconitis 6 weight portion Radix Aconiti Kusnezoffii 12 weight portions
Agkistrodon 1.5 weight portion Flos Sophoraes 130 weight portion Folium Ginkgos 200 weight portions
The Radix Paeoniae Alba 80 weight portion Rhizoma Chuanxiongs 40 weight portion Rhizoma Et Radix Notopterygiis 80 weight portions.
The optimum ratio of pharmaceutical composition of the present invention is:
The Cortex Eucommiae 25 weight portion Radix Dipsacis 15 weight portion Radix Notoginseng 16 weight portions
Rhizoma Drynariae 15 weight portion Radix Codonopsis 40 weight portion Arillus Longans 10 weight portions
Radix Salviae Miltiorrhizae 130 weight portion Fructus Schisandrae Chinensis 9 weight portion Radix Ginsengs 13 weight portions
Radix Polygoni Multiflori 20 weight portion Cortex Acanthopanciss 12 weight portion Fructus Chaenomeliss 9 weight portions
The Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.5 weight portion Rhizoma valerianae latifoliaes 40 weight portion Radixs Astragali 40 weight portions
Radix Angelicae Sinensis 10 weight portion Semen Strychnis 1.2 weight portion Herba Aristolochiae Mollissimaes 15 weight portions
Caulis Piperis Kadsurae 25 weight portion Cortex erythrinaes 15 weight portion Asterias amurensis Lutkenes 25 weight portions
Fructus Mori 10 weight portion Rhizoma Dioscoreaes 40 weight portion Fructus Lycii 40 weight portions
Sargassum 80 weight portion Radix Aconitis 12 weight portion Radix Aconiti Kusnezoffii 6 weight portions
Agkistrodon 2.5 weight portion Flos Sophoraes 70 weight portion Folium Ginkgos 400 weight portions
The Radix Paeoniae Alba 40 weight portion Rhizoma Chuanxiongs 80 weight portion Rhizoma Et Radix Notopterygiis 40 weight portions.
The described Radix Astragali is a Radix Astragali, and Rhizoma Dioscoreae is a Rhizoma Dioscoreae, and Semen Strychni is a Semen Strychni(processed).
Pharmaceutical composition of the present invention adds the dosage form that conventional adjuvant is made clinical acceptance according to practice of pharmacy.Described dosage form is tablet, capsule, pill, a material agent, oral liquid, injection, drop pill or lyophilized injectable powder.
Preparation of drug combination method of the present invention is for to be ground into fine powder with the Cortex Eucommiae, Radix Dipsaci, Radix Notoginseng, Rhizoma Drynariae, Radix Codonopsis, Arillus Longan, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Polygoni Multiflori, Cortex Acanthopancis, Fructus Chaenomelis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Astragali, Radix Angelicae Sinensis, Semen Strychni, Herba Aristolochiae Mollissimae, Caulis Piperis Kadsurae, Cortex erythrinae, Asterias amurensis Lutken, Fructus Mori, Rhizoma Dioscoreae, Fructus Lycii, Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon, the Radix Paeoniae Alba, Rhizoma Chuanxiong with common process; Rhizoma Et Radix Notopterygii, Sargassum, Radix Salviae Miltiorrhizae, Folium Ginkgo, Flos Sophorae, Rhizoma valerianae latifoliae were soaked 2-4 hour with pure water 550-1650 weight portion, fried in shallow oil 20-60 minute with big fire, using little fire instead fried in shallow oil 20-60 minute, filter and remove residue, medicinal residues reuse 300-900 weight portion pure decocting 30-90 minute, filter and remove residue, medicinal liquid and secondary medicinal liquid merge and add above-mentioned medicated powder mixing for the first time, add conventional adjuvant again and make the tablet of clinical acceptance, capsule, pill or a material agent.
The preferred for preparation method of pharmaceutical composition of the present invention is: the Cortex Eucommiae, Radix Dipsaci, Radix Notoginseng, Rhizoma Drynariae, Radix Codonopsis, Arillus Longan, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Polygoni Multiflori, Cortex Acanthopancis, Fructus Chaenomelis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Astragali, Radix Angelicae Sinensis, Semen Strychni, Herba Aristolochiae Mollissimae, Caulis Piperis Kadsurae, Cortex erythrinae, Asterias amurensis Lutken, Fructus Mori, Rhizoma Dioscoreae, Fructus Lycii, Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon, the Radix Paeoniae Alba, Rhizoma Chuanxiong are ground into fine powder with common process; Rhizoma Et Radix Notopterygii, Sargassum, Radix Salviae Miltiorrhizae, Folium Ginkgo, Flos Sophorae, Rhizoma valerianae latifoliae were soaked 3 hours with pure water 1100 weight portions, fried in shallow oil 40 minutes with big fire, using little fire instead fried in shallow oil 40 minutes, filter and remove residue, the pure decocting of medicinal residues reuse 600 weight portions 60 minutes, filter and remove residue, medicinal liquid and secondary medicinal liquid merging for the first time adds above-mentioned medicated powder and dextrin 200 weight portions are made pill.
Pharmaceutical composition of the present invention is remarkable to treatment cardiovascular and cerebrovascular disease effect, and has no side effect.
Following experimental example is used to further specify the present invention:
Pharmaceutical composition of the present invention is from 1989-2006 treatment cardiovascular and cerebrovascular disease people 910 examples, and clinical report is as follows:
1, clinical data: among the 910 routine patients, male 567 examples, women 343 examples, minimum 41 years old of age, maximum 75 years old; The course of disease is the shortest 9 months, and is the longest 5 years.The various pathological changes that all belong to cardiovascular and cerebrovascular disease are as hypertension, hyperlipidemia, high blood viscosity, hyperglycemia, arteriosclerosis, latent coronary heart disease, myocardial infarction, ischemic hypoxia apoplexy, hemorrhagic cerebral apoplexy.
2, diagnostic criteria: Electrocardioscopy, CT examination, routine are carried out blood glucose, examination of sugar in urine, blood pressure inspection etc.
3, Therapeutic Method
3.1 prescription: Cortex Eucommiae 20g, Radix Dipsaci 20g, Radix Notoginseng 12g, Rhizoma Drynariae 20g, Radix Codonopsis 30g. Arillus Longan 15g, Radix Salviae Miltiorrhizae 100g, Fructus Schisandrae Chinensis 12g, Radix Ginseng 10g, Radix Polygoni Multiflori 30g, Cortex Acanthopancis 12g, Fructus Chaenomelis 12g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2g, Rhizoma valerianae latifoliae 60g, Radix Astragali 30g, Radix Angelicae Sinensis 15g, Semen Strychni (system) 0.9g, Herba Aristolochiae Mollissimae 20g, Caulis Piperis Kadsurae 20g, Cortex erythrinae 20g, Asterias amurensis Lutken 20g, Fructus Mori 15g, Rhizoma Dioscoreae 30g, Fructus Lycii 60g, Sargassum 60g, Radix Aconiti 9g, careless bird 9g, Agkistrodon 2g, Flos Sophorae 100g, Folium Ginkgo 300g, Radix Paeoniae Alba 60g, Rhizoma Chuanxiong 60g, Rhizoma Et Radix Notopterygii 60g.
3.2 preparation method is ground into fine powder with the Cortex Eucommiae, Radix Dipsaci, Radix Notoginseng, Rhizoma Drynariae, Radix Codonopsis, Arillus Longan, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Polygoni Multiflori, Cortex Acanthopancis, Fructus Chaenomelis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Astragali, Radix Angelicae Sinensis, Semen Strychni, Herba Aristolochiae Mollissimae, Caulis Piperis Kadsurae, Cortex erythrinae, Asterias amurensis Lutken, Fructus Mori, Rhizoma Dioscoreae, Fructus Lycii, Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon, the Radix Paeoniae Alba, Rhizoma Chuanxiong with common process; Rhizoma Et Radix Notopterygii, Sargassum, Radix Salviae Miltiorrhizae, Folium Ginkgo, Flos Sophorae, Rhizoma valerianae latifoliae were soaked 3 hours with pure water 1100g, fried in shallow oil 40 minutes with big fire, using little fire instead fried in shallow oil 40 minutes, filter and remove residue, the pure decocting of medicinal residues reuse 600g 60 minutes, filter and remove residue, medicinal liquid and secondary medicinal liquid merging for the first time adds above-mentioned medicated powder and dextrin 200g makes pill.
3.3 instructions of taking: three times on the oral one, a 4-6 gram, obey I-2 hour after meal ante cibum, and 50 days is 1 course of treatment.
4, criterion of therapeutical effect:
Cure: clinical symptom disappearance, no limitation of activity, stabilizing blood pressure blood sugar lowering, blood fat reducing, reduction cholesterolemia, triglyceride and low density lipoprotein, LDL, blood viscosity lowering, antiplatelet aggregation and anti thrombotic action increase immunity of organisms.
Produce effects: clinical symptoms is significantly extenuated, and the diseased region activity is clearly better, and movable back sturdy pines is comfortable.No pain, the rhythm of the heart surely closes, the limb activity freedom.
Take a turn for the better: clinical disease has significantly and alleviates.
Invalid: the state of an illness does not have significant change before and after the treatment.
5, therapeutic outcome: among the 910 routine patients, cure 603 examples, produce effects 10 examples, invalid 70 examples, total effective rate 92.3%.The shortest treatment 79 days, Changzhi is treated 1 year 09 months.
6, model case
Case 1: Yuan XX, the woman, 63 years old now, suffered from hypertension before 10 years, cause apoplexy, often headache, insomnia, forgetful, nervously breathe hard, arrhythmia, angina pectoris, limbs fatigue, tinnitus, bradykinesia, visual deterioration etc.Take the pill of the embodiment of the invention 1, three times on the one, a 4-6 gram, obey I-2 hour after meal ante cibum, and 50 days is 1 course of treatment.The state of an illness takes a favorable turn after 2 months, continues again and has taken state of an illness recovery from illness in 6 months.The effect that pharmaceutical composition of the present invention has good QI invigorating to enrich blood simultaneously more can dredging vascellum, and the painstaking effort circulation is quickened, and alleviates the deficiency of heart-blood phenomenon, and medicine can be supplied painstaking effort, makes brain cell improve symptoms such as insomnia under the competent situation of oxygen supply energy supply.
Case 2: open XX, the woman 65 years old, suffers from myocardial infarction, coronary heart disease, heart failure, the heavy numbness of limb adynamia.Take the capsule of the embodiment of the invention 2, recovery from illness after 8 months.Pharmaceutical composition of the present invention can improve the antioxidative activity, bad oxide in the blood vessel there is good scavenging action, take contrast blood test discovery density lipoprotein rising after 1 month, triglyceride descends, cholesterol descends, and low density lipoprotein, LDL descends, and vasodilation is strengthened, blood circulation quickens, and high blood viscosity, hyperlipidemia reduce.
Case 3: pottery XX, the man, 41 years old now, to suffer from that hypertension, limb artery sclerosis, numbness of hands and feet are unable, the limbs pastiness, be slow in action, the cause of disease is that hyperlipidemia, high blood viscosity cause, endogenous cause of ill is that cells in vivo can't obtain due to the required nutrient substance.Painstaking effort are under-supply, cause the abundant oxygen that brings of blood circulation and the nutrition for want of of cells in vivo and muscle and the hungry disease of muscle occurs, make limbs pastiness, numbness of hands and feet unable etc.Take the oral liquid of the embodiment of the invention 3, recovery from illness after 5 months.Pharmaceutical composition of the present invention can be removed blood vessel lipid accumulation, blood viscosity at night, simultaneously fatty impurity and the toxin in higher, the blood of the tensity of blood pressure regulating maincenter.Vessel softening reduces blood viscosity, dredging vascellum and antioxidation effectively.
Case 4: Xu XX, the man, 68 years old, suffer from diabetes for many years, take the pill of the embodiment of the invention 1, three times on the one, a 4-6 gram, obey I-2 hour after meal ante cibum, and 50 days is 1 course of treatment.Be clearly better recovery from illness in 11 months in five months.Pharmaceutical composition of the present invention has the effect of blood fat reducing, blood sugar lowering, regulates human body blood viscosity, blood pressure and blood lipoid effectively, protection painstaking effort vascular system.But the generation of the cardio-cerebrovascular complication that the prophylactic treatment diabetes causes can not cause blood sugar increasing, and the deficiency that helps diabetes human endocrine insulin is with additional.
Case 5: square XX, the man 56 years old now, suffers from diabetes for many years, June 8 1996 first visit date.The medical history summary: finding during this patient's health check-up that blood glucose increases, is (I type) diabetes at that time at the Hefei hospital diagnosis, once is in hospital twice, antidiabetic drugs such as orally-taken blood sugar reducing diabetes pill, and note the food conditioning state of an illness, treatment is for years kept.Calendar year 2001, the state of an illness increased the weight of, and blood glucose 10.7mmol/L glucose in urine (+) continues to take said medicine and fails to respond to any medical treatment, and used insulin always on a small quantity and kept, and in February, 2003 is through tcm diagnosis, quench one's thirst (type of deficiency of both QI and YIN), Western medicine diagnose diabetes (I type).Treatment process: the sugared 10.4mmol/L glucose in urine (+) of having a blood test in June, 2003, after take the capsule of the embodiment of the invention 2, blood glucose 6.0mmol/L glucose in urine (-) after 7 months, after take recovery from illness in 9 months again.
Case 6: Lee X, the woman, 49 years old, check to be diabetes (II type) through the People's Hospital, Fuyang, antidiabetic drugs such as oral always outstanding blood sugar lowering diformin tablet, blood glucose maintains between the 7.6-7.8mmol/L always, because of chronic hepatic injury is arranged, therefore can't increase the consumption of antidiabetic drug, blood glucose is not effectively controlled always.Since the pill of taking the embodiment of the invention 1, three times on the one, a 4-6 gram, obey I-2 hour after meal ante cibum, and 50 days is 1 course of treatment.4 months, check, blood glucose 60mmol/L glucose in urine (-), after continued again to take 7 months, complete more.
Following embodiment is used to further specify the present invention:
The specific embodiment
Embodiment 1:
Cortex Eucommiae 20kg Radix Dipsaci 20kg Radix Notoginseng 12kg
Rhizoma Drynariae 20kg Radix Codonopsis 30kg Arillus Longan 15kg
Radix Salviae Miltiorrhizae 100kg Fructus Schisandrae Chinensis 12kg Radix Ginseng 10kg
Radix Polygoni Multiflori 30kg Cortex Acanthopancis 12kg Fructus Chaenomelis 12kg
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2kg Rhizoma valerianae latifoliae 60kg Radix Astragali 30kg
Radix Angelicae Sinensis 15kg Semen Strychni 0.9kg Herba Aristolochiae Mollissimae 20kg
Caulis Piperis Kadsurae 20kg Cortex erythrinae 20kg Asterias amurensis Lutken 20kg
Fructus Mori 15kg Rhizoma Dioscoreae 30kg Fructus Lycii 60kg
Sargassum 60kg Radix Aconiti 9kg Radix Aconiti Kusnezoffii 9kg
Agkistrodon 2kg Flos Sophorae 100kg Folium Ginkgo 300kg
Radix Paeoniae Alba 60kg Rhizoma Chuanxiong 60kg Rhizoma Et Radix Notopterygii 60kg
The Cortex Eucommiae, Radix Dipsaci, Radix Notoginseng, Rhizoma Drynariae, Radix Codonopsis, Arillus Longan, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Polygoni Multiflori, Cortex Acanthopancis, Fructus Chaenomelis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Astragali, Radix Angelicae Sinensis, Semen Strychni, Herba Aristolochiae Mollissimae, Caulis Piperis Kadsurae, Cortex erythrinae, Asterias amurensis Lutken, Fructus Mori, Rhizoma Dioscoreae, Fructus Lycii, Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon, the Radix Paeoniae Alba, Rhizoma Chuanxiong are ground into fine powder with common process; Rhizoma Et Radix Notopterygii, Sargassum, Radix Salviae Miltiorrhizae, Folium Ginkgo, Flos Sophorae, Rhizoma valerianae latifoliae were soaked 3 hours with pure water 1100kg, fried in shallow oil 40 minutes with big fire, using little fire instead fried in shallow oil 40 minutes, filter and remove residue, the pure decocting of medicinal residues reuse 600kg 60 minutes, filter and remove residue, medicinal liquid and secondary medicinal liquid merging for the first time adds above-mentioned medicated powder and dextrin 200kg makes pill.Three times on the oral one, a 4-6 gram, obey I-2 hour after meal ante cibum, and 50 days is 1 course of treatment.
Embodiment 2:
Cortex Eucommiae 15kg Radix Dipsaci 25kg Radix Notoginseng 8kg
Rhizoma Drynariae 25kg Radix Codonopsis 20kg Arillus Longan 20kg
Radix Salviae Miltiorrhizae 70kg Fructus Schisandrae Chinensis 15kg Radix Ginseng 7kg
Radix Polygoni Multiflori 40kg Cortex Acanthopancis 9kg Fructus Chaenomelis 15kg
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 1.5kg Rhizoma valerianae latifoliae 80kg Radix Astragali 20kg
Radix Angelicae Sinensis 20kg Semen Strychni 0.6kg Herba Aristolochiae Mollissimae 25kg
Caulis Piperis Kadsurae 15kg Cortex erythrinae 25kg Asterias amurensis Lutken 15kg
Fructus Mori 20kg Rhizoma Dioscoreae 20kg Fructus Lycii 80kg
Sargassum 40kg Radix Aconiti 6kg Radix Aconiti Kusnezoffii 12kg
Agkistrodon 1.5kg Flos Sophorae 130kg Folium Ginkgo 200kg
Radix Paeoniae Alba 80kg Rhizoma Chuanxiong 40kg Rhizoma Et Radix Notopterygii 80kg.
Said medicine technology routinely adds conventional adjuvant and makes capsule.
Embodiment 3:
Cortex Eucommiae 25kg Radix Dipsaci 15kg Radix Notoginseng 16kg
Rhizoma Drynariae 15kg Radix Codonopsis 40kg Arillus Longan 10kg
Radix Salviae Miltiorrhizae 130kg Fructus Schisandrae Chinensis 9kg Radix Ginseng 13kg
Radix Polygoni Multiflori 20kg Cortex Acanthopancis 12kg Fructus Chaenomelis 9kg
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.5kg Rhizoma valerianae latifoliae 40kg Radix Astragali 40kg
Radix Angelicae Sinensis 10kg Semen Strychni 1.2kg Herba Aristolochiae Mollissimae 15kg
Caulis Piperis Kadsurae 25kg Cortex erythrinae 15kg Asterias amurensis Lutken 25kg
Fructus Mori 10kg Rhizoma Dioscoreae 40kg Fructus Lycii 40kg
Sargassum 80kg Radix Aconiti 12kg Radix Aconiti Kusnezoffii 6kg
Agkistrodon 2.5kg Flos Sophorae 70kg Folium Ginkgo 400kg
Radix Paeoniae Alba 40kg Rhizoma Chuanxiong 80kg Rhizoma Et Radix Notopterygii 40kg.
Said medicine technology routinely adds conventional adjuvant and makes oral liquid.
Embodiment 4:
Cortex Eucommiae 20kg Radix Dipsaci 20kg Radix Notoginseng 12kg
Rhizoma Drynariae 20kg Radix Codonopsis 30kg Arillus Longan 15kg
Radix Salviae Miltiorrhizae 100kg Fructus Schisandrae Chinensis 12kg Radix Ginseng 10kg
Radix Polygoni Multiflori 30kg Cortex Acanthopancis 12kg Fructus Chaenomelis 12kg
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2kg Rhizoma valerianae latifoliae 60kg Radix Astragali 30kg
Radix Angelicae Sinensis 15kg Semen Strychni 0.9kg Herba Aristolochiae Mollissimae 20kg
Caulis Piperis Kadsurae 20kg Cortex erythrinae 20kg Asterias amurensis Lutken 20kg
Fructus Mori 15kg Rhizoma Dioscoreae 30kg Fructus Lycii 60kg
Sargassum 60kg Radix Aconiti 9kg Radix Aconiti Kusnezoffii 9kg
Agkistrodon 2kg Flos Sophorae 100kg Folium Ginkgo 300kg
Radix Paeoniae Alba 60kg Rhizoma Chuanxiong 60kg Rhizoma Et Radix Notopterygii 60kg
Said medicine technology routinely adds conventional adjuvant and makes injection.
Embodiment 5:
Cortex Eucommiae 15kg Radix Dipsaci 25kg Radix Notoginseng 8kg
Rhizoma Drynariae 25kg Radix Codonopsis 20kg Arillus Longan 20kg
Radix Salviae Miltiorrhizae 70kg Fructus Schisandrae Chinensis 15kg Radix Ginseng 7kg
Radix Polygoni Multiflori 40kg Cortex Acanthopancis 9kg Fructus Chaenomelis 15kg
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 1.5kg Rhizoma valerianae latifoliae 80kg Radix Astragali 20kg
Radix Angelicae Sinensis 20kg Semen Strychni 0.6kg Herba Aristolochiae Mollissimae 25kg
Caulis Piperis Kadsurae 15kg Cortex erythrinae 25kg Asterias amurensis Lutken 15kg
Fructus Mori 20kg Rhizoma Dioscoreae 20kg Fructus Lycii 80kg
Sargassum 40kg Radix Aconiti 6kg Radix Aconiti Kusnezoffii 12kg
Agkistrodon 1.5kg Flos Sophorae 130kg Folium Ginkgo 200kg
Radix Paeoniae Alba 80kg Rhizoma Chuanxiong 40kg Rhizoma Et Radix Notopterygii 80kg.
Said medicine technology routinely adds conventional adjuvant and makes drop pill.
Embodiment 6:
Cortex Eucommiae 25kg Radix Dipsaci 15kg Radix Notoginseng 16kg
Rhizoma Drynariae 15kg Radix Codonopsis 40kg Arillus Longan 10kg
Radix Salviae Miltiorrhizae 130kg Fructus Schisandrae Chinensis 9kg Radix Ginseng 13kg
Radix Polygoni Multiflori 20kg Cortex Acanthopancis 12kg Fructus Chaenomelis 9kg
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.5kg Rhizoma valerianae latifoliae 40kg Radix Astragali 40kg
Radix Angelicae Sinensis 10kg Semen Strychni 1.2kg Herba Aristolochiae Mollissimae 15kg
Caulis Piperis Kadsurae 25kg Cortex erythrinae 15kg Asterias amurensis Lutken 25kg
Fructus Mori 10kg Rhizoma Dioscoreae 40kg Fructus Lycii 40kg
Sargassum 80kg Radix Aconiti 12kg Radix Aconiti Kusnezoffii 6kg
Agkistrodon 2.5kg Flos Sophorae 70kg Folium Ginkgo 400kg
Radix Paeoniae Alba 40kg Rhizoma Chuanxiong 80kg Rhizoma Et Radix Notopterygii 40kg.
Said medicine technology routinely adds conventional adjuvant and makes freeze-dried powder.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease is characterized in that said composition is to be made by following crude drug:
Cortex Eucommiae 10-30 weight portion Radix Dipsaci 10-30 weight portion Radix Notoginseng 6-18 weight portion
Rhizoma Drynariae 10-30 weight portion Radix Codonopsis 15-45 weight portion Arillus Longan 7-23 weight portion
Radix Salviae Miltiorrhizae 50-150 weight portion Fructus Schisandrae Chinensis 6-18 weight portion Radix Ginseng 5-15 weight portion
Radix Polygoni Multiflori 15-45 weight portion Cortex Acanthopancis 6-18 weight portion Fructus Chaenomelis 6-18 weight portion
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 1-3 weight portion Rhizoma valerianae latifoliae 30-90 weight portion Radix Astragali 15-45 weight portion
Radix Angelicae Sinensis 7-23 weight portion Semen Strychni 0.4-1.4 weight portion Herba Aristolochiae Mollissimae 10-30 weight portion
Caulis Piperis Kadsurae 10-30 weight portion Cortex erythrinae 10-30 weight portion Asterias amurensis Lutken 10-30 weight portion
Fructus Mori 7-23 weight portion Rhizoma Dioscoreae 15-45 weight portion Fructus Lycii 30-90 weight portion
Sargassum 30-90 weight portion Radix Aconiti 4-14 weight portion Radix Aconiti Kusnezoffii 4-14 weight portion
Agkistrodon 1-3 weight portion Flos Sophorae 50-150 weight portion Folium Ginkgo 150-450 weight portion
Radix Paeoniae Alba 30-90 weight portion Rhizoma Chuanxiong 30-90 weight portion Rhizoma Et Radix Notopterygii 30-90 weight portion.
2, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
The Cortex Eucommiae 20 weight portion Radix Dipsacis 20 weight portion Radix Notoginseng 12 weight portions
Rhizoma Drynariae 20 weight portion Radix Codonopsis 30 weight portion Arillus Longans 15 weight portions
Radix Salviae Miltiorrhizae 100 weight portion Fructus Schisandrae Chinensis 12 weight portion Radix Ginsengs 10 weight portions
Radix Polygoni Multiflori 30 weight portion Cortex Acanthopanciss 12 weight portion Fructus Chaenomeliss 12 weight portions
Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2 weight portion Rhizoma valerianae latifoliaes 60 weight portion Radix Astragali 30 weight portions
Radix Angelicae Sinensis 15 weight portion Semen Strychnis 0.9 weight portion Herba Aristolochiae Mollissimae 20 weight portions
Caulis Piperis Kadsurae 20 weight portion Cortex erythrinaes 20 weight portion Asterias amurensis Lutkenes 20 weight portions
Fructus Mori 15 weight portion Rhizoma Dioscoreae 30 weight portion Fructus Lycii 60 weight portions
Sargassum 60 weight portion Radix Aconitis 9 weight portion Radix Aconiti Kusnezoffii 9 weight portions
Agkistrodon 2 weight portion Flos Sophoraes 100 weight portion Folium Ginkgos 300 weight portions
The Radix Paeoniae Alba 60 weight portion Rhizoma Chuanxiongs 60 weight portion Rhizoma Et Radix Notopterygiis 60 weight portions.
3, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
The Cortex Eucommiae 15 weight portion Radix Dipsacis 25 weight portion Radix Notoginseng 8 weight portions
Rhizoma Drynariae 25 weight portion Radix Codonopsis 20 weight portion Arillus Longans 20 weight portions
Radix Salviae Miltiorrhizae 70 weight portion Fructus Schisandrae Chinensis 15 weight portion Radix Ginsengs 7 weight portions
Radix Polygoni Multiflori 40 weight portion Cortex Acanthopanciss 9 weight portion Fructus Chaenomeliss 15 weight portions
The Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 1.5 weight portion Rhizoma valerianae latifoliaes 80 weight portion Radixs Astragali 20 weight portions
Radix Angelicae Sinensis 20 weight portion Semen Strychnis 0.6 weight portion Herba Aristolochiae Mollissimae 25 weight portions
Caulis Piperis Kadsurae 15 weight portion Cortex erythrinaes 25 weight portion Asterias amurensis Lutkenes 15 weight portions
Fructus Mori 20 weight portion Rhizoma Dioscoreaes 20 weight portion Fructus Lycii 80 weight portions
Sargassum 40 weight portion Radix Aconitis 6 weight portion Radix Aconiti Kusnezoffii 12 weight portions
Agkistrodon 1.5 weight portion Flos Sophoraes 130 weight portion Folium Ginkgos 200 weight portions
The Radix Paeoniae Alba 80 weight portion Rhizoma Chuanxiongs 40 weight portion Rhizoma Et Radix Notopterygiis 80 weight portions.
4, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
The Cortex Eucommiae 25 weight portion Radix Dipsacis 15 weight portion Radix Notoginseng 16 weight portions
Rhizoma Drynariae 15 weight portion Radix Codonopsis 40 weight portion Arillus Longans 10 weight portions
Radix Salviae Miltiorrhizae 130 weight portion Fructus Schisandrae Chinensis 9 weight portion Radix Ginsengs 13 weight portions
Radix Polygoni Multiflori 20 weight portion Cortex Acanthopanciss 12 weight portion Fructus Chaenomeliss 9 weight portions
The Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.5 weight portion Rhizoma valerianae latifoliaes 40 weight portion Radixs Astragali 40 weight portions
Radix Angelicae Sinensis 10 weight portion Semen Strychnis 1.2 weight portion Herba Aristolochiae Mollissimaes 15 weight portions
Caulis Piperis Kadsurae 25 weight portion Cortex erythrinaes 15 weight portion Asterias amurensis Lutkenes 25 weight portions
Fructus Mori 10 weight portion Rhizoma Dioscoreaes 40 weight portion Fructus Lycii 40 weight portions
Sargassum 80 weight portion Radix Aconitis 12 weight portion Radix Aconiti Kusnezoffii 6 weight portions
Agkistrodon 2.5 weight portion Flos Sophoraes 70 weight portion Folium Ginkgos 400 weight portions
The Radix Paeoniae Alba 40 weight portion Rhizoma Chuanxiongs 80 weight portion Rhizoma Et Radix Notopterygiis 40 weight portions.
5, according to the described pharmaceutical composition of one of claim 1-4, it is characterized in that the described Radix Astragali is a Radix Astragali, Rhizoma Dioscoreae is a Rhizoma Dioscoreae, Semen Strychni is a Semen Strychni(processed).
6, according to claim 1,2,3,4 or 5 described pharmaceutical compositions, it is characterized in that said composition adds the dosage form that conventional adjuvant is made clinical acceptance according to practice of pharmacy, comprise tablet, capsule, pill, a material agent, oral liquid, injection, drop pill or lyophilized injectable powder.
7,, it is characterized in that the preparation method of said composition is: the Cortex Eucommiae, Radix Dipsaci, Radix Notoginseng, Rhizoma Drynariae, Radix Codonopsis, Arillus Longan, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Polygoni Multiflori, Cortex Acanthopancis, Fructus Chaenomelis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Astragali, Radix Angelicae Sinensis, Semen Strychni, Herba Aristolochiae Mollissimae, Caulis Piperis Kadsurae, Cortex erythrinae, Asterias amurensis Lutken, Fructus Mori, Rhizoma Dioscoreae, Fructus Lycii, Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon, the Radix Paeoniae Alba, Rhizoma Chuanxiong are ground into fine powder with common process according to the described pharmaceutical composition of one of claim 1-4; Rhizoma Et Radix Notopterygii, Sargassum, Radix Salviae Miltiorrhizae, Folium Ginkgo, Flos Sophorae, Rhizoma valerianae latifoliae were soaked 2-4 hour with pure water 550-1650 bulking value part, fried in shallow oil 20-60 minute with big fire, using little fire instead fried in shallow oil 20-60 minute, filter and remove residue, medicinal residues reuse 300-900 bulking value part pure decocting 30-90 minute, filter and remove residue, medicinal liquid and secondary medicinal liquid merge and add above-mentioned medicated powder mixing for the first time, add conventional adjuvant again and make the tablet of clinical acceptance, capsule, pill or a material agent.
8, preparation of drug combination method according to claim 7 is characterized in that this preparation method is: the Cortex Eucommiae, Radix Dipsaci, Radix Notoginseng, Rhizoma Drynariae, Radix Codonopsis, Arillus Longan, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Polygoni Multiflori, Cortex Acanthopancis, Fructus Chaenomelis, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Astragali, Radix Angelicae Sinensis, Semen Strychni, Herba Aristolochiae Mollissimae, Caulis Piperis Kadsurae, Cortex erythrinae, Asterias amurensis Lutken, Fructus Mori, Rhizoma Dioscoreae, Fructus Lycii, Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon, the Radix Paeoniae Alba, Rhizoma Chuanxiong are ground into fine powder with common process; Rhizoma Et Radix Notopterygii, Sargassum, Radix Salviae Miltiorrhizae, Folium Ginkgo, Flos Sophorae, Rhizoma valerianae latifoliae were soaked 3 hours with pure water 1100 weight portions, fried in shallow oil 40 minutes with big fire, using little fire instead fried in shallow oil 40 minutes, filter and remove residue, the pure decocting of medicinal residues reuse 600 weight portions 60 minutes, filter and remove residue, medicinal liquid and secondary medicinal liquid merging for the first time adds above-mentioned medicated powder and dextrin 200 weight portions are made pill.
9, according to claim 1,2,3, the application of 4 or 5 described pharmaceutical compositions in the medicine of preparation treatment cardiovascular and cerebrovascular disease.
10, pharmaceutical composition according to claim 9 is characterized in that in the application of preparation treatment cardiovascular and cerebrovascular disease described cardiovascular and cerebrovascular disease is meant hypertension, hyperlipidemia, high blood viscosity, hyperglycemia, arteriosclerosis, latent coronary heart disease, myocardial infarction or apoplexy.
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* Cited by examiner, † Cited by third party| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406795A (en) * | 2011-11-03 | 2012-04-11 | 铜陵市松马食品包装机械制造有限责任公司 | Tea paste for treating anemia and preparation method thereof |
| CN103330879A (en) * | 2013-05-28 | 2013-10-02 | 陈松 | Traditional Chinese medicine for treating apoplexy |
| CN104258075A (en) * | 2014-09-19 | 2015-01-07 | 宋振红 | Traditional Chinese medicine preparation for treating heart-kidney deficiency type coronary heart disease |
| CN107412508A (en) * | 2017-04-13 | 2017-12-01 | 肖志远 | A kind of Chinese medicine composition of dredging vascellum |
Family Cites Families (1)
* Cited by examiner, † Cited by third party| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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2006
- 2006-04-28 CN CNB2006100789677A patent/CN100444870C/en not_active Expired - Fee Related
Cited By (5)
* Cited by examiner, † Cited by third party| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406795A (en) * | 2011-11-03 | 2012-04-11 | 铜陵市松马食品包装机械制造有限责任公司 | Tea paste for treating anemia and preparation method thereof |
| CN103330879A (en) * | 2013-05-28 | 2013-10-02 | 陈松 | Traditional Chinese medicine for treating apoplexy |
| CN103330879B (en) * | 2013-05-28 | 2015-04-15 | 陈松 | Traditional Chinese medicine for treating apoplexy |
| CN104258075A (en) * | 2014-09-19 | 2015-01-07 | 宋振红 | Traditional Chinese medicine preparation for treating heart-kidney deficiency type coronary heart disease |
| CN107412508A (en) * | 2017-04-13 | 2017-12-01 | 肖志远 | A kind of Chinese medicine composition of dredging vascellum |
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| CN100444870C (en) | 2008-12-24 |
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