DK434985A - METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES - Google Patents
- ️Thu Mar 27 1986
DK434985A - METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES - Google Patents
METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES Download PDFInfo
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Publication number
- DK434985A DK434985A DK434985A DK434985A DK434985A DK 434985 A DK434985 A DK 434985A DK 434985 A DK434985 A DK 434985A DK 434985 A DK434985 A DK 434985A DK 434985 A DK434985 A DK 434985A Authority
- DK
- Denmark Prior art keywords
- alkyl
- mono
- rifamycines
- imidazo
- hydrogen Prior art date
- 1984-09-26
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pyridoimidazorifamycins of the formula <IMAGE> where R is hydrogen or acetyl, R1 and R2 independently denote hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1- 3)-alkylamino-(C1-4)-alkyl, (C1-3)-alkoxy-(C-4)-alkyl, hydroxymethyl, hydroxy-(C2-4)-alkyl, cyano, halogen, nitro, mercapto, (C1-4)-alkylthio, phenylthio, carbamoyl, or mono- or di-(C1-4)-alkylcarbamoyl, or R1 and R2, together with two neighbouring carbon atoms in the pyridine nucleus, form a benzene ring which is optionally substituted by 1 or 2 methyl or ethyl groups, are prepared by one mol equivalent of rifamycin B being reacted with from about 1 to about 9 mol equivalents of a 2-aminopyridine in the presence of a suitable oxidizing agent. Commercially available starting materials are used in the process.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT03581/84A IT1199413B (en) | 1984-09-26 | 1984-09-26 | PROCESS FOR THE PREPARATION OF PIRIDO-IMIDAZO-RIFAMICINE |
IT358184 | 1984-09-26 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK434985D0 DK434985D0 (en) | 1985-09-25 |
DK434985A true DK434985A (en) | 1986-03-27 |
DK161706B DK161706B (en) | 1991-08-05 |
DK161706C DK161706C (en) | 1992-01-20 |
Family
ID=11110114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK434985A DK161706C (en) | 1984-09-26 | 1985-09-25 | METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES |
Country Status (10)
Country | Link |
---|---|
AR (1) | AR243892A1 (en) |
AT (1) | AT387020B (en) |
CA (1) | CA1218650A (en) |
DK (1) | DK161706C (en) |
ES (1) | ES8604735A1 (en) |
FI (1) | FI83875C (en) |
GR (1) | GR852312B (en) |
IT (1) | IT1199413B (en) |
NO (1) | NO165107C (en) |
PT (1) | PT81198B (en) |
Families Citing this family (8)
* Cited by examiner, † Cited by third partyPublication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7902206B2 (en) | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
ITMI20032144A1 (en) | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | REFLEXIMINE POLIMORPHIC FORMS, PROCESSES TO OBTAIN THEM AND |
US7906542B2 (en) | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
PT1698630E (en) | 2005-03-03 | 2014-09-15 | Alfa Wassermann Spa | New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
US7709634B2 (en) | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
ITBO20120368A1 (en) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | COMPOSITIONS INCLUDING RIFAXIMINA AND AMINO ACIDS, RIFAXIMINE CRYSTALS DERIVING FROM SUCH COMPOSITIONS AND THEIR USE. |
ES2621557T3 (en) | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Polymorphic mixture of rifaximin and its use for the preparation of solid formulations |
ES2742106T3 (en) | 2014-05-12 | 2020-02-13 | Alfasigma Spa | New form of solvated rifaximin crystal, production, compositions and uses thereof |
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1984
- 1984-09-26 IT IT03581/84A patent/IT1199413B/en active
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1985
- 1985-09-23 GR GR852312A patent/GR852312B/el unknown
- 1985-09-25 NO NO853771A patent/NO165107C/en unknown
- 1985-09-25 CA CA000491511A patent/CA1218650A/en not_active Expired
- 1985-09-25 ES ES547265A patent/ES8604735A1/en not_active Expired
- 1985-09-25 FI FI853683A patent/FI83875C/en not_active IP Right Cessation
- 1985-09-25 DK DK434985A patent/DK161706C/en not_active IP Right Cessation
- 1985-09-25 AT AT279785A patent/AT387020B/en not_active IP Right Cessation
- 1985-09-26 AR AR30174785A patent/AR243892A1/en active
- 1985-09-26 PT PT8119885A patent/PT81198B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK161706B (en) | 1991-08-05 |
PT81198B (en) | 1987-09-30 |
ATA279785A (en) | 1988-04-15 |
IT1199413B (en) | 1988-12-30 |
GR852312B (en) | 1986-01-24 |
AR243892A1 (en) | 1993-09-30 |
ES8604735A1 (en) | 1986-02-16 |
FI853683A0 (en) | 1985-09-25 |
DK161706C (en) | 1992-01-20 |
NO165107C (en) | 1990-12-27 |
FI83875C (en) | 1991-09-10 |
IT8403581A0 (en) | 1984-09-26 |
PT81198A (en) | 1985-10-01 |
ES547265A0 (en) | 1986-02-16 |
DK434985D0 (en) | 1985-09-25 |
NO853771L (en) | 1986-04-01 |
NO165107B (en) | 1990-09-17 |
FI853683L (en) | 1986-03-27 |
AT387020B (en) | 1988-11-25 |
CA1218650A (en) | 1987-03-03 |
FI83875B (en) | 1991-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
1998-05-11 | PBP | Patent lapsed |