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DK434985A - METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES - Google Patents

  • ️Thu Mar 27 1986

DK434985A - METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES - Google Patents

METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES Download PDF

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Publication number
DK434985A
DK434985A DK434985A DK434985A DK434985A DK 434985 A DK434985 A DK 434985A DK 434985 A DK434985 A DK 434985A DK 434985 A DK434985 A DK 434985A DK 434985 A DK434985 A DK 434985A Authority
DK
Denmark
Prior art keywords
alkyl
mono
rifamycines
imidazo
hydrogen
Prior art date
1984-09-26
Application number
DK434985A
Other languages
Danish (da)
Other versions
DK161706B (en
DK161706C (en
DK434985D0 (en
Inventor
Vicenzo Cannata
Gian Franco Tamagnone
Manuela Campana
Silvano Piani
Raul Roberto Alpino
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1984-09-26
Filing date
1985-09-25
Publication date
1986-03-27
1985-09-25 Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
1985-09-25 Publication of DK434985D0 publication Critical patent/DK434985D0/en
1986-03-27 Publication of DK434985A publication Critical patent/DK434985A/en
1991-08-05 Publication of DK161706B publication Critical patent/DK161706B/en
1992-01-20 Application granted granted Critical
1992-01-20 Publication of DK161706C publication Critical patent/DK161706C/en

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pyridoimidazorifamycins of the formula <IMAGE> where R is hydrogen or acetyl, R1 and R2 independently denote hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1- 3)-alkylamino-(C1-4)-alkyl, (C1-3)-alkoxy-(C-4)-alkyl, hydroxymethyl, hydroxy-(C2-4)-alkyl, cyano, halogen, nitro, mercapto, (C1-4)-alkylthio, phenylthio, carbamoyl, or mono- or di-(C1-4)-alkylcarbamoyl, or R1 and R2, together with two neighbouring carbon atoms in the pyridine nucleus, form a benzene ring which is optionally substituted by 1 or 2 methyl or ethyl groups, are prepared by one mol equivalent of rifamycin B being reacted with from about 1 to about 9 mol equivalents of a 2-aminopyridine in the presence of a suitable oxidizing agent. Commercially available starting materials are used in the process.

DK434985A 1984-09-26 1985-09-25 METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES DK161706C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT03581/84A IT1199413B (en) 1984-09-26 1984-09-26 PROCESS FOR THE PREPARATION OF PIRIDO-IMIDAZO-RIFAMICINE
IT358184 1984-09-26

Publications (4)

Publication Number Publication Date
DK434985D0 DK434985D0 (en) 1985-09-25
DK434985A true DK434985A (en) 1986-03-27
DK161706B DK161706B (en) 1991-08-05
DK161706C DK161706C (en) 1992-01-20

Family

ID=11110114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK434985A DK161706C (en) 1984-09-26 1985-09-25 METHOD FOR PREPARING PYRIDO-IMIDAZO RIFAMYCINES

Country Status (10)

Country Link
AR (1) AR243892A1 (en)
AT (1) AT387020B (en)
CA (1) CA1218650A (en)
DK (1) DK161706C (en)
ES (1) ES8604735A1 (en)
FI (1) FI83875C (en)
GR (1) GR852312B (en)
IT (1) IT1199413B (en)
NO (1) NO165107C (en)
PT (1) PT81198B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
ITMI20032144A1 (en) 2003-11-07 2005-05-08 Alfa Wassermann Spa REFLEXIMINE POLIMORPHIC FORMS, PROCESSES TO OBTAIN THEM AND
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
PT1698630E (en) 2005-03-03 2014-09-15 Alfa Wassermann Spa New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
ITBO20120368A1 (en) 2012-07-06 2014-01-07 Alfa Wassermann Spa COMPOSITIONS INCLUDING RIFAXIMINA AND AMINO ACIDS, RIFAXIMINE CRYSTALS DERIVING FROM SUCH COMPOSITIONS AND THEIR USE.
ES2621557T3 (en) 2014-03-31 2017-07-04 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
ES2742106T3 (en) 2014-05-12 2020-02-13 Alfasigma Spa New form of solvated rifaximin crystal, production, compositions and uses thereof

Also Published As

Publication number Publication date
DK161706B (en) 1991-08-05
PT81198B (en) 1987-09-30
ATA279785A (en) 1988-04-15
IT1199413B (en) 1988-12-30
GR852312B (en) 1986-01-24
AR243892A1 (en) 1993-09-30
ES8604735A1 (en) 1986-02-16
FI853683A0 (en) 1985-09-25
DK161706C (en) 1992-01-20
NO165107C (en) 1990-12-27
FI83875C (en) 1991-09-10
IT8403581A0 (en) 1984-09-26
PT81198A (en) 1985-10-01
ES547265A0 (en) 1986-02-16
DK434985D0 (en) 1985-09-25
NO853771L (en) 1986-04-01
NO165107B (en) 1990-09-17
FI853683L (en) 1986-03-27
AT387020B (en) 1988-11-25
CA1218650A (en) 1987-03-03
FI83875B (en) 1991-05-31

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Legal Events

Date Code Title Description
1998-05-11 PBP Patent lapsed