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DK554688A - PHARMACEUTICAL ACTIVE DERIVATIVES OF (R) -5-PENTYL-AMINO-5-OXOPENTANIC ACID AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF, THEIR PREPARATION AND USE - Google Patents

  • ️Fri Dec 02 1988
PHARMACEUTICAL ACTIVE DERIVATIVES OF (R) -5-PENTYL-AMINO-5-OXOPENTANIC ACID AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF, THEIR PREPARATION AND USE

Info

Publication number
DK554688A
DK554688A DK554688A DK554688A DK554688A DK 554688 A DK554688 A DK 554688A DK 554688 A DK554688 A DK 554688A DK 554688 A DK554688 A DK 554688A DK 554688 A DK554688 A DK 554688A Authority
DK
Denmark
Prior art keywords
acceptable salts
pentyl
pharmaceutical
active derivatives
amino
Prior art date
1987-02-05
Application number
DK554688A
Other languages
Danish (da)
Other versions
DK172007B1 (en
DK554688D0 (en
Inventor
Francesco Makovec
Rolando Christe
Walter Peris
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1987-02-05
Filing date
1988-10-04
Publication date
1988-12-02
1987-02-05 Priority claimed from IT8767076A external-priority patent/IT1217123B/en
1988-10-04 Application filed by Rotta Research Lab filed Critical Rotta Research Lab
1988-10-04 Publication of DK554688D0 publication Critical patent/DK554688D0/en
1988-12-02 Publication of DK554688A publication Critical patent/DK554688A/en
1997-09-15 Application granted granted Critical
1997-09-15 Publication of DK172007B1 publication Critical patent/DK172007B1/en

Links

  • 150000003839 salts Chemical class 0.000 title abstract 2
  • YNCGRFHDJXWYFG-SECBINFHSA-N C(CCCC)C(CC[C@H](C(=O)O)N)=O Chemical class C(CCCC)C(CC[C@H](C(=O)O)N)=O YNCGRFHDJXWYFG-SECBINFHSA-N 0.000 title 1
  • 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
  • 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 abstract 1
  • -1 3,4-dimethylphenyl Chemical group 0.000 abstract 1
  • 102100025841 Cholecystokinin Human genes 0.000 abstract 1
  • 101800001982 Cholecystokinin Proteins 0.000 abstract 1
  • 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
  • 230000003042 antagnostic effect Effects 0.000 abstract 1
  • 125000004432 carbon atom Chemical group C* 0.000 abstract 1
  • 229940107137 cholecystokinin Drugs 0.000 abstract 1
  • 125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
  • IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 1
  • 125000001424 substituent group Chemical group 0.000 abstract 1

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Optically active derivatives of (R)-5-pentylamino-5- oxopentanoic acid, and their pharmaceutically acceptable salts, having an antagonistic activity against cholecystokinin and having the general formula <IMAGE> where R1 is selected from the group which consists of 2- naphthyl, 3,4-dichlorophenyl and 3,4-dimethylphenyl, and R2 denotes a pentyl group or an alkoxy alkyl group having 4 carbon atoms, and where the substituents on the chiral central group (marked with an asterisk in formula (I)) have the R configuration (rectus).

DK554688A 1987-02-05 1988-10-04 Pharmaceutically active derivatives of (R)-5-pentylamino- 5-oxopentanoic acid, and pharmaceutical preparations thereof DK172007B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT6707687 1987-02-05
IT8767076A IT1217123B (en) 1987-02-05 1987-02-05 OPTICALLY ACTIVE DERIVATIVES OF ACID 5 PENTILAMINE 5 OXO PENTANOIC R WITH ANTAGONIST ACTIVITY OF THE CHOLECISTOKININ AND PROCEDURE FOR THEIR PREPARATION
PCT/EP1988/000061 WO1988005774A1 (en) 1987-02-05 1988-01-28 Derivatives of (r) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity
EP8800061 1988-01-28

Publications (3)

Publication Number Publication Date
DK554688D0 DK554688D0 (en) 1988-10-04
DK554688A true DK554688A (en) 1988-12-02
DK172007B1 DK172007B1 (en) 1997-09-15

Family

ID=26069548

Family Applications (1)

Application Number Title Priority Date Filing Date
DK554688A DK172007B1 (en) 1987-02-05 1988-10-04 Pharmaceutically active derivatives of (R)-5-pentylamino- 5-oxopentanoic acid, and pharmaceutical preparations thereof

Country Status (1)

Country Link
DK (1) DK172007B1 (en)

Also Published As

Publication number Publication date
DK172007B1 (en) 1997-09-15
DK554688D0 (en) 1988-10-04

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Legal Events

Date Code Title Description
1997-09-15 B1 Patent granted (law 1993)
2007-10-15 PBP Patent lapsed

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