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ES2070087A1 - Indole derivatives - Google Patents

  • ️Tue May 16 1995

ES2070087A1 - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
ES2070087A1
ES2070087A1 ES09301804A ES9301804A ES2070087A1 ES 2070087 A1 ES2070087 A1 ES 2070087A1 ES 09301804 A ES09301804 A ES 09301804A ES 9301804 A ES9301804 A ES 9301804A ES 2070087 A1 ES2070087 A1 ES 2070087A1 Authority
ES
Spain
Prior art keywords
indole derivatives
compounds
useful
vasodilators
migraine
Prior art date
1993-08-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301804A
Other languages
Spanish (es)
Other versions
ES2070087B1 (en
Inventor
John E Macor
Martin James Wythes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1993-08-13
Filing date
1993-08-13
Publication date
1995-05-16
1993-08-13 Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
1993-08-13 Priority to ES9301804A priority Critical patent/ES2070087B1/en
1995-05-16 Publication of ES2070087A1 publication Critical patent/ES2070087A1/en
1996-02-16 Application granted granted Critical
1996-02-16 Publication of ES2070087B1 publication Critical patent/ES2070087B1/en
2013-08-13 Anticipated expiration legal-status Critical
Status Expired - Lifetime legal-status Critical Current

Links

  • 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
  • 150000002475 indoles Chemical class 0.000 title 1
  • 150000001875 compounds Chemical class 0.000 abstract 2
  • QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
  • 208000019695 Migraine disease Diseases 0.000 abstract 1
  • 239000000556 agonist Substances 0.000 abstract 1
  • 239000002220 antihypertensive agent Substances 0.000 abstract 1
  • 229940030600 antihypertensive agent Drugs 0.000 abstract 1
  • 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
  • 208000035475 disorder Diseases 0.000 abstract 1
  • 206010027599 migraine Diseases 0.000 abstract 1
  • 229940076279 serotonin Drugs 0.000 abstract 1
  • 229940124549 vasodilator Drugs 0.000 abstract 1
  • 239000003071 vasodilator agent Substances 0.000 abstract 1

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula I, where W, n, m, R1 and R11 are defined in detail in the report. These compounds are potential serotonin (5-HT1) agonists and are useful for the treatment of migraine and other disorders, also being useful as centrally acting antihypertensives and vasodilators.

ES9301804A 1993-08-13 1993-08-13 DERIVATIVES OF INDOL Expired - Lifetime ES2070087B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301804A ES2070087B1 (en) 1993-08-13 1993-08-13 DERIVATIVES OF INDOL

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301804A ES2070087B1 (en) 1993-08-13 1993-08-13 DERIVATIVES OF INDOL

Publications (2)

Publication Number Publication Date
ES2070087A1 true ES2070087A1 (en) 1995-05-16
ES2070087B1 ES2070087B1 (en) 1996-02-16

Family

ID=8282858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301804A Expired - Lifetime ES2070087B1 (en) 1993-08-13 1993-08-13 DERIVATIVES OF INDOL

Country Status (1)

Country Link
ES (1) ES2070087B1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0313397A1 (en) * 1987-10-23 1989-04-26 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
EP0438230A2 (en) * 1990-01-17 1991-07-24 MERCK SHARP & DOHME LTD. Indole-substituted five-membered heteroaromatic compounds
WO1991018897A1 (en) * 1990-06-07 1991-12-12 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
WO1992006976A1 (en) * 1990-10-18 1992-04-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivative
WO1992013856A1 (en) * 1991-02-12 1992-08-20 Pfizer Inc. 5-heteroyl indole derivatives
WO1993020073A1 (en) * 1992-04-07 1993-10-14 Pfizer Inc. Indole derivatives as 5-ht1 agonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0313397A1 (en) * 1987-10-23 1989-04-26 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
EP0438230A2 (en) * 1990-01-17 1991-07-24 MERCK SHARP & DOHME LTD. Indole-substituted five-membered heteroaromatic compounds
WO1991018897A1 (en) * 1990-06-07 1991-12-12 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
WO1992006976A1 (en) * 1990-10-18 1992-04-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivative
WO1992013856A1 (en) * 1991-02-12 1992-08-20 Pfizer Inc. 5-heteroyl indole derivatives
WO1993020073A1 (en) * 1992-04-07 1993-10-14 Pfizer Inc. Indole derivatives as 5-ht1 agonists

Also Published As

Publication number Publication date
ES2070087B1 (en) 1996-02-16

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