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GB1036368A - Method for the manufacture of lactose-containing tablets - Google Patents

  • ️Wed Jul 20 1966

GB1036368A - Method for the manufacture of lactose-containing tablets - Google Patents

Method for the manufacture of lactose-containing tablets

Info

Publication number
GB1036368A
GB1036368A GB4247964A GB4247964A GB1036368A GB 1036368 A GB1036368 A GB 1036368A GB 4247964 A GB4247964 A GB 4247964A GB 4247964 A GB4247964 A GB 4247964A GB 1036368 A GB1036368 A GB 1036368A Authority
GB
United Kingdom
Prior art keywords
lactose
syrup
beta
water
tablets
Prior art date
1963-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4247964A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kraft Inc
Original Assignee
Kraft Inc
National Dairy Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-10-31
Filing date
1964-10-19
Publication date
1966-07-20
1964-10-19 Application filed by Kraft Inc, National Dairy Products Corp filed Critical Kraft Inc
1966-07-20 Publication of GB1036368A publication Critical patent/GB1036368A/en
Status Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K5/00—Lactose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Lactose, which contains at least 50% by weight beta-lactose, is prepared by drying or crystallizing a syrup or solution of lactose in water at a temperature above 200 DEG F. The preferred method comprises roll drying a syrup preprepared by dissolving in water lactose that has been recrystallized from whey concentrate, the syrup containing about 35 to 50% by weight of lactose. The syrup is fed into the bite of a double drum dryer, whose rollers are steam heated to 265 DEG to 340 DEG F., and thus dried to give a product containing about 0.3% of water, and about 75% of beta-lactose, the remainder being alpha-lactose.ALSO:Lactose-containing tablets, wherein the lactose comprises a major proportion of beta-lactose, and constitutes at least 25% by weight of the tablet, are prepared by forming a free-flowing mixture of an active ingredient and the lactose, and forming into tablets in the absence of added moisture. Suitable lactose, having a beta-lactose content of at least 50%, may be prepared by crystallising the lactose from aqueous solution, preferably a syrup, at a temperature above 200 DEG F. (e.g. by roll-drying on steam-heated rollers; see Division C2). The lactose may be colored by adding a water-soluble dye to the aqueous solution. An example is given for preparing tablets containing aspirin or soy-flour as the active ingredient, using a 75% by weight beta-lactose-containing roll-dried lactose. The tablets made from such lactose are said to be more resistant to capping and more readily water-soluble than those of the usual, mainly alpha, lactose.

GB4247964A 1963-10-31 1964-10-19 Method for the manufacture of lactose-containing tablets Expired GB1036368A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32050563A 1963-10-31 1963-10-31

Publications (1)

Publication Number Publication Date
GB1036368A true GB1036368A (en) 1966-07-20

Family

ID=23246735

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4247964A Expired GB1036368A (en) 1963-10-31 1964-10-19 Method for the manufacture of lactose-containing tablets

Country Status (3)

Country Link
DE (1) DE1258549B (en)
GB (1) GB1036368A (en)
NL (1) NL145140B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2042386A1 (en) * 1969-04-29 1971-02-12 Sucrest Corp
WO1994012200A1 (en) * 1992-12-02 1994-06-09 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5935602A (en) * 1991-11-22 1999-08-10 The Procter & Gamble Company Dosage forms of risedronate
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6596710B1 (en) 1991-11-22 2003-07-22 The Procter & Gamble Company Dosage forms of risedronate
US6623755B2 (en) 1999-07-01 2003-09-23 Merck & Co., Inc. Pharmaceutical tablets
EP1498498A1 (en) * 2003-07-15 2005-01-19 Kraft Foods R & D, Inc. Whey powders of improved taste

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9100691A (en) * 1991-04-19 1992-11-16 Dmv Campina Bv TABLETING AUXILIARY.

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2042386A1 (en) * 1969-04-29 1971-02-12 Sucrest Corp
US6596710B1 (en) 1991-11-22 2003-07-22 The Procter & Gamble Company Dosage forms of risedronate
US5935602A (en) * 1991-11-22 1999-08-10 The Procter & Gamble Company Dosage forms of risedronate
EP0690719A1 (en) 1992-12-02 1996-01-10 Merck & Co. Inc. Dry mix formulation for bisphosphonic acids
US5681590A (en) * 1992-12-02 1997-10-28 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5882656A (en) * 1992-12-02 1999-03-16 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
US6090410A (en) * 1992-12-02 2000-07-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6194004B1 (en) 1992-12-02 2001-02-27 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6517867B2 (en) 1992-12-02 2003-02-11 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
WO1994012200A1 (en) * 1992-12-02 1994-06-09 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6623755B2 (en) 1999-07-01 2003-09-23 Merck & Co., Inc. Pharmaceutical tablets
EP1498498A1 (en) * 2003-07-15 2005-01-19 Kraft Foods R & D, Inc. Whey powders of improved taste

Also Published As

Publication number Publication date
NL6412650A (en) 1965-05-03
DE1258549B (en) 1968-01-11
NL145140B (en) 1975-03-17

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