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SG11201407669QA - Methods for improving safety of blood-brain barrier transport - Google Patents

  • ️Tue Dec 30 2014

SG11201407669QA - Methods for improving safety of blood-brain barrier transport - Google Patents

Methods for improving safety of blood-brain barrier transport

Info

Publication number
SG11201407669QA
SG11201407669QA SG11201407669QA SG11201407669QA SG11201407669QA SG 11201407669Q A SG11201407669Q A SG 11201407669QA SG 11201407669Q A SG11201407669Q A SG 11201407669QA SG 11201407669Q A SG11201407669Q A SG 11201407669QA SG 11201407669Q A SG11201407669Q A SG 11201407669QA Authority
SG
Singapore
Prior art keywords
lllll
genentech
san francisco
international
south san
Prior art date
2012-05-21
Application number
SG11201407669QA
Inventor
Ryan Jefferson Watts
Zuchero Joy Yu
Jessica Couch
Mark Dennis
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2012-05-21
Filing date
2013-05-20
Publication date
2014-12-30
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48534514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201407669Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
2013-05-20 Application filed by Genentech Inc filed Critical Genentech Inc
2014-12-30 Publication of SG11201407669QA publication Critical patent/SG11201407669QA/en

Links

  • 230000008499 blood brain barrier function Effects 0.000 title abstract 4
  • 210000001218 blood-brain barrier Anatomy 0.000 title abstract 4
  • 230000001404 mediated effect Effects 0.000 abstract 1
  • 239000000203 mixture Substances 0.000 abstract 1
  • 230000008520 organization Effects 0.000 abstract 1
  • 102000005962 receptors Human genes 0.000 abstract 1
  • 108020003175 receptors Proteins 0.000 abstract 1
  • 102220240796 rs553605556 Human genes 0.000 abstract 1

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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/177062 A2 (51) International Patent Classification: C07K16/28 (2006.01) A61K39/395 (2006.01) C07K16/40 (2006.01) A61P 25/00 (2006.01) C07K16/46 (2006.01) A ft IK 47/48 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication (30) Priority Language: Data: 61/649,878 61/698,495 61/763,915 21 May 2012 (21.05.2012) 7 September 2012 (07.09.2012) 12 February 2013 (12.02.2013) PCT/US2013/041860 20 May 2013 (20.05.2013) English English US US us (71) Applicant (for all designated States except AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT ; RO, RS, SE, SI, SK, SM, TR): GENENTECH, INC. [US/US]; DNA Way, 1 South San Francisco, Califor­ nia 94080 (US). (71) Applicant (for AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only): F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, CH-4070 Basel (CH). (72) Inventors: WATTS, Ryan, Jefferson; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). YU ZUCHERO, Joy; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). COUCH, Jessica; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). DENNIS, Mark; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). [Continued on next page] (54) Title: METHODS FOR IMPROVING SAFETY OF BLOOD-BRAIN BARRIER TRANSPORT O O ^ 0 sb \"5 c. 01 o <D ^3 CO jj j C5 60- 40- ZU- Hr Post-close (57) Abstract: The present invention relates to compositions and methods for improving the safety of blood-brain barrier receptor-mediated blood-brain barrier transport. ~™i— 50 50 —r~ 50 Anti~TfR D Anti-TfR / 0 6 AC El Control igG WO 2013/177062 A2 I lllll llllllll II llllll III lllll lllll III III III lllll llll llll lllll lllll lllll lllll lllllll llll llll (74) Agents: ELLIOTT, Jennifer, L. et al.; Genentech, Inc., 1 DNA Way, Mail Stop 49, South San Francisco, Califor­ nia 94080 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a))

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