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WO2005035500A3 - Therapeutic agents useful for treating pain - Google Patents

  • ️Thu May 19 2005

WO2005035500A3 - Therapeutic agents useful for treating pain - Google Patents

Therapeutic agents useful for treating pain Download PDF

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Publication number
WO2005035500A3
WO2005035500A3 PCT/US2004/033621 US2004033621W WO2005035500A3 WO 2005035500 A3 WO2005035500 A3 WO 2005035500A3 US 2004033621 W US2004033621 W US 2004033621W WO 2005035500 A3 WO2005035500 A3 WO 2005035500A3 Authority
WO
WIPO (PCT)
Prior art keywords
treating pain
therapeutic agents
agents useful
compound
diaminoalkylene
Prior art date
2003-10-09
Application number
PCT/US2004/033621
Other languages
French (fr)
Other versions
WO2005035500A2 (en
Inventor
Parviz Gharagozloo
Original Assignee
Euro Celtique Sa
Parviz Gharagozloo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2003-10-09
Filing date
2004-10-11
Publication date
2005-05-19
2004-10-11 Application filed by Euro Celtique Sa, Parviz Gharagozloo filed Critical Euro Celtique Sa
2005-04-21 Publication of WO2005035500A2 publication Critical patent/WO2005035500A2/en
2005-05-19 Publication of WO2005035500A3 publication Critical patent/WO2005035500A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632Organic additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention provides a compound of formula (I) (where R1, R1’, R2, R3, X, Y, Z and n are disclosed herein) or a pharmaceutically acceptable salt thereof (s “Diaminoalkylene Compound”); pharmaceutical compositions comprising an effective amount of a Diaminoalkylene Compound; and methods for treating pain, as well as other conditions, comprising administering to an animal in need thereof an effective amount of a Diaminoalkylene Compound.

PCT/US2004/033621 2003-10-09 2004-10-11 Therapeutic agents useful for treating pain WO2005035500A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51081003P 2003-10-09 2003-10-09
US60/510,810 2003-10-09

Publications (2)

Publication Number Publication Date
WO2005035500A2 WO2005035500A2 (en) 2005-04-21
WO2005035500A3 true WO2005035500A3 (en) 2005-05-19

Family

ID=34435130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033621 WO2005035500A2 (en) 2003-10-09 2004-10-11 Therapeutic agents useful for treating pain

Country Status (1)

Country Link
WO (1) WO2005035500A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062985A1 (en) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituted bis (hetero) aromatic N-ethyl-propiolamides and their use for the preparation of medicaments
DE102005062986A1 (en) 2005-12-28 2007-07-05 Grünenthal GmbH Substituted propiolic acid amides and their use for the preparation of medicaments
DE102005062991A1 (en) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituted thiazoles and their use for the preparation of medicaments
DE102005062990A1 (en) 2005-12-28 2007-07-05 Grünenthal GmbH Substituted thiazoles and their use for the preparation of medicaments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093236A1 (en) * 2002-05-02 2003-11-13 Euro-Celtique, S.A. 1-(pyrid-2-yl)-piperazine compounds as metabotropic glutamate receptor inhibitor
WO2004029044A1 (en) * 2002-09-24 2004-04-08 Euro-Celtique, S.A. Pyrimidine compounds as therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093236A1 (en) * 2002-05-02 2003-11-13 Euro-Celtique, S.A. 1-(pyrid-2-yl)-piperazine compounds as metabotropic glutamate receptor inhibitor
WO2004029044A1 (en) * 2002-09-24 2004-04-08 Euro-Celtique, S.A. Pyrimidine compounds as therapeutic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ISHIZUMI ET AL: "Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (tandospirone) and related compounds", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 39, no. 9, 1991, pages 2288 - 2300, XP002103452, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
WO2005035500A2 (en) 2005-04-21

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