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Epogam evening primrose oil treatment in atopic dermatitis and asthma

Abstract

Essential fatty acids are claimed to have positive effects in atopic diseases. In a double blind, placebo controlled, parallel group study 58 out of 60 children, with atopic dermatitis and the need for regular treatment with topical skin steroids, completed a 16 weeks' treatment period with either Epogam evening primrose oil or placebo capsules. Twenty two of these subjects also had asthma. The parents used diaries to record symptom scores and concomitant medication. Peak expiratory flow was measured and disease activity was monitored by the clinician every four weeks. The plasma concentrations of essential fatty acids increased significantly in the group treated with Epogam capsules. The study demonstrated significant improvements of the eczema symptoms but no significant difference was found between the placebo and the Epogam groups. No therapeutic effect was shown on asthma symptoms or fidget.

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Selected References

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  1. Bamford J. T., Gibson R. W., Renier C. M. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids). J Am Acad Dermatol. 1985 Dec;13(6):959–965. doi: 10.1016/s0190-9622(85)70245-9. [DOI] [PubMed] [Google Scholar]
  2. Berth-Jones J., Graham-Brown R. A. Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. Lancet. 1993 Jun 19;341(8860):1557–1560. doi: 10.1016/0140-6736(93)90697-f. [DOI] [PubMed] [Google Scholar]
  3. Biagi P. L., Bordoni A., Masi M., Ricci G., Fanelli C., Patrizi A., Ceccolini E. A long-term study on the use of evening primrose oil (Efamol) in atopic children. Drugs Exp Clin Res. 1988;14(4):285–290. [PubMed] [Google Scholar]
  4. Björkstén B. Fatty acids and inflammatory responses--is there a connection? Acta Paediatr Scand Suppl. 1989;351:76–79. doi: 10.1111/j.1651-2227.1989.tb11214.x. [DOI] [PubMed] [Google Scholar]
  5. Bordoni A., Biagi P. L., Masi M., Ricci G., Fanelli C., Patrizi A., Ceccolini E. Evening primrose oil (Efamol) in the treatment of children with atopic eczema. Drugs Exp Clin Res. 1988;14(4):291–297. [PubMed] [Google Scholar]
  6. Broberg A., Kalimo K., Lindblad B., Swanbeck G. Parental education in the treatment of childhood atopic eczema. Acta Derm Venereol. 1990;70(6):495–499. [PubMed] [Google Scholar]
  7. Dry J., Vincent D. Effect of a fish oil diet on asthma: results of a 1-year double-blind study. Int Arch Allergy Appl Immunol. 1991;95(2-3):156–157. doi: 10.1159/000235421. [DOI] [PubMed] [Google Scholar]
  8. Ebden P., Bevan C., Banks J., Fennerty A., Walters E. H. A study of evening primrose seed oil in atopic asthma. Prostaglandins Leukot Essent Fatty Acids. 1989 Feb;35(2):69–72. doi: 10.1016/0952-3278(89)90167-1. [DOI] [PubMed] [Google Scholar]
  9. Guenther L., Wexler D. Efamol in the treatment of atopic dermatitis. J Am Acad Dermatol. 1987 Nov;17(5 Pt 1):860–860. doi: 10.1016/s0190-9622(87)80298-0. [DOI] [PubMed] [Google Scholar]
  10. Hederos C. A. Vanligt med alternativ behandling av allergiskt sjuka barn. Lakartidningen. 1988 Oct 26;85(43):3580-1, 3583. [PubMed] [Google Scholar]
  11. Horrobin D. F., Stewart C. Evening primrose oil and atopic eczema. Lancet. 1990 Jul 7;336(8706):50–50. doi: 10.1016/0140-6736(90)91560-w. [DOI] [PubMed] [Google Scholar]
  12. Horrobin D. F., Stewart C. Evening primrose oil in atopic eczema. Lancet. 1990 Apr 7;335(8693):864–865. doi: 10.1016/0140-6736(90)90987-g. [DOI] [PubMed] [Google Scholar]
  13. Kirsch C. M., Payan D. G., Wong M. Y., Dohlman J. G., Blake V. A., Petri M. A., Offenberger J., Goetzl E. J., Gold W. M. Effect of eicosapentaenoic acid in asthma. Clin Allergy. 1988 Mar;18(2):177–187. doi: 10.1111/j.1365-2222.1988.tb02857.x. [DOI] [PubMed] [Google Scholar]
  14. Melnik B. C. Atopic dermatitis and essential fatty acid metabolism. Curr Probl Dermatol. 1991;20:215–227. doi: 10.1159/000420026. [DOI] [PubMed] [Google Scholar]
  15. Morse P. F., Horrobin D. F., Manku M. S., Stewart J. C., Allen R., Littlewood S., Wright S., Burton J., Gould D. J., Holt P. J. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. Br J Dermatol. 1989 Jul;121(1):75–90. doi: 10.1111/j.1365-2133.1989.tb01403.x. [DOI] [PubMed] [Google Scholar]
  16. Salob S. P., Atherton D. J. Prevalence of respiratory symptoms in children with atopic dermatitis attending pediatric dermatology clinics. Pediatrics. 1993 Jan;91(1):8–12. [PubMed] [Google Scholar]
  17. Sharpe G. R., Farr P. M. Evening primrose oil and eczema. Lancet. 1990 Mar 17;335(8690):667–668. doi: 10.1016/0140-6736(90)90459-i. [DOI] [PubMed] [Google Scholar]
  18. Sharpe G. R., Farr P. M. Evening primrose oil and eczema. Lancet. 1990 May 26;335(8700):1283–1283. doi: 10.1016/0140-6736(90)91350-j. [DOI] [PubMed] [Google Scholar]
  19. Stenius-Aarniala B., Aro A., Hakulinen A., Ahola I., Seppälä E., Vapaatalo H. Evening primose oil and fish oil are ineffective as supplementary treatment of bronchial asthma. Ann Allergy. 1989 Jun;62(6):534–537. [PubMed] [Google Scholar]
  20. Wright S., Burton J. L. Oral evening-primrose-seed oil improves atopic eczema. Lancet. 1982 Nov 20;2(8308):1120–1122. doi: 10.1016/s0140-6736(82)92784-2. [DOI] [PubMed] [Google Scholar]