pmc.ncbi.nlm.nih.gov

Evaluation of the Ciba Corning Biotrack 512 coagulation monitor for the control of oral anticoagulation

Abstract

The Ciba Corning Biotrack 512 coagulation monitor requires a minimal degree of technical expertise to operate, and is already in use for near-patient testing. This study evaluated the monitor for possible use in decentralised control of oral anticoagulant treatment. The monitor compared well with Manchester Reagent, suggesting that it could be used in areas where this thromboplastin is used for centralised control. The inability of the monitor to allow for locally determined geometric mean normal prothrombin times in the calculation of the International Normalised Ratio (INR), and possibly the high International Sensitivity Index (ISI) of the thromboplastin used with the monitor, resulted in poor comparability with some other thromboplastins, particularly Thrombotest. These problems need to be addressed if the monitor is to be used for decentralised anticoagulant control.

950

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ansell J., Holden A., Knapic N. Patient self-management of oral anticoagulation guided by capillary (fingerstick) whole blood prothrombin times. Arch Intern Med. 1989 Nov;149(11):2509–2511. [PubMed] [Google Scholar]
  2. Bland J. M., Altman D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed] [Google Scholar]
  3. Hailey D. M., Lea A. R. Developments in near-patient testing. Med Lab Sci. 1990 Oct;47(4):319–325. [PubMed] [Google Scholar]
  4. Lucas F. V., Duncan A., Jay R., Coleman R., Craft P., Chan B., Winfrey L., Mungall D. R., Hirsh J. A novel whole blood capillary technic for measuring the prothrombin time. Am J Clin Pathol. 1987 Oct;88(4):442–446. doi: 10.1093/ajcp/88.4.442. [DOI] [PubMed] [Google Scholar]
  5. Poller L. United Kingdom external quality assessment in blood coagulation: the first 21 years. J Clin Pathol. 1989 Jan;42(1):1–3. doi: 10.1136/jcp.42.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Rachel J. M., Plapp F. V. Bedside blood grouping. Med Lab Sci. 1990 Oct;47(4):330–336. [PubMed] [Google Scholar]
  7. Taberner D. A., Poller L., Thomson J. M., Darby K. V. Effect of international sensitivity index (ISI) of thromboplastins on precision of international normalised ratios (INR) J Clin Pathol. 1989 Jan;42(1):92–96. doi: 10.1136/jcp.42.1.92. [DOI] [PMC free article] [PubMed] [Google Scholar]