pmc.ncbi.nlm.nih.gov

Occurrence of human pancreatic polypeptide in pancreatic endocrine tumors. Possible implication in the watery diarrhea syndrome

. 1976 Dec;85(3):675–684.

Abstract

Eighteen endocrine pancreatic tumors were examined for the occurrence of cells producing insulin, glucagon, gastrin, human pancreatic polypeptide (HPP), and vasoactive intestinal polypeptide (VIP) and for A1 cells. More than half of the tumors were mixed, i.e., they contained more than one type of hormone-producing cell. The clinical symptoms were attributable only to one of the hormones produced by the mixed tumors. Three of four tumors causing the watery diarrhea syndrome contained both VIP and HPP cells. In one such tumor there was a strong predominance of HPP cells; the serum HPP levels of this patient were a thousandfold elevated, whereas her VIP levels were within the normal range. Several lines of evidence point to HPP as a possible agent causing the watery diarrhea syndrome. In many of our patients, HPP cells hyperplasia was present in the extratumoral pancreas. Such hyperplasia may give rise to the raised serum HPP levels seen in many patients having endocrine pancreatic tumors.

675

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbezat G. O., Grossman M. I. Cholera-like diarrhoea induced by glucagon plus gastrin. Lancet. 1971 May 15;1(7707):1025–1026. doi: 10.1016/s0140-6736(71)91428-0. [DOI] [PubMed] [Google Scholar]
  2. Bloom S. R., Polak J. M., Pearse A. G. Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet. 1973 Jul 7;2(7819):14–16. doi: 10.1016/s0140-6736(73)91947-8. [DOI] [PubMed] [Google Scholar]
  3. Bryant M. G., Polak M. M., Modlin I., Bloom S. R., Albuquerque R. H., Pearse A. G. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet. 1976 May 8;1(7967):991–993. doi: 10.1016/s0140-6736(76)91863-8. [DOI] [PubMed] [Google Scholar]
  4. Creutzfeldt W. Pancreatic endocrine tumors--the riddle or their origin and hormone secretion. Isr J Med Sci. 1975 Jul;11(7):762–776. [PubMed] [Google Scholar]
  5. Dumont A. E., Martelli A. B. Pathogenesis of pancreatic edema following exocrine duct obstruction. Ann Surg. 1968 Aug;168(2):302–309. doi: 10.1097/00000658-196808000-00020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Elias E., Polak J. M., Bloom S. R., Pearse A. G., Welbourn R. B., Booth C. C., Kuzio M., Brown J. C. Pancreatic cholera due to production of gastric inhibitory polypeptide. Lancet. 1972 Oct 14;2(7781):791–793. doi: 10.1016/s0140-6736(72)92148-4. [DOI] [PubMed] [Google Scholar]
  7. Greider M. H., Rosai J., McGuigan J. E. The human pancreatic islet cells and their tumors. II. Ulcerogenic and diarrheogenic tumors. Cancer. 1974 May;33(5):1423–1443. doi: 10.1002/1097-0142(197405)33:5<1423::aid-cncr2820330529>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  8. Kimmel J. R., Hayden L. J., Pollock H. G. Isolation and characterization of a new pancreatic polypeptide hormone. J Biol Chem. 1975 Dec 25;250(24):9369–9376. [PubMed] [Google Scholar]
  9. Kimmel J. R., Pollock H. G., Hazelwood R. L. Isolation and characterization of chicken insulin. Endocrinology. 1968 Dec;83(6):1323–1330. doi: 10.1210/endo-83-6-1323. [DOI] [PubMed] [Google Scholar]
  10. Larsson L. I., Edvinsson L., Fahrenkrug J., Håkanson R., Owman C., Schaffalitzky de Muckadell O., Sundler F. Immunohistochemical localization of a vasodilatory polypeptide (VIP) in cerebrovascular nerves. Brain Res. 1976 Aug 27;113(2):400–404. doi: 10.1016/0006-8993(76)90951-3. [DOI] [PubMed] [Google Scholar]
  11. Larsson L. I., Fahrenkrug J., Schaffalitzky De Muckadell O., Sundler F., Håkanson R., Rehfeld J. R. Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons. Proc Natl Acad Sci U S A. 1976 Sep;73(9):3197–3200. doi: 10.1073/pnas.73.9.3197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Larsson L. I., Grimelius L., Håkanson R., Rehfeld J. F., Stadil F., Holst J., Angervall L., Sundler F. Mixed endocrine pancreatic tumors producing several peptide hormones. Am J Pathol. 1975 May;79(2):271–284. [PMC free article] [PubMed] [Google Scholar]
  13. Larsson L. I., Sundler F., Håkanson R. Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tissue Res. 1975;156(2):167–171. doi: 10.1007/BF00221800. [DOI] [PubMed] [Google Scholar]
  14. Larsson L. I., Sundler F., Håkanson R. Pancreatic polypeptide - a postulated new hormone: identification of its cellular storage site by light and electron microscopic immunocytochemistry. Diabetologia. 1976 Jul;12(3):211–226. doi: 10.1007/BF00422088. [DOI] [PubMed] [Google Scholar]
  15. Larsson L. I., Sundler F., Håkanson R., Pollock H. G., Kimmel J. R. Localization of APP, a postulated new hormone, to a pancreatic endocrine cell type. Histochemistry. 1974;42(4):377–382. doi: 10.1007/BF00492685. [DOI] [PubMed] [Google Scholar]
  16. Pearse A. G., Polak J. M. Bifunctional reagents as vapour- and liquid-phase fixatives for immunohistochemistry. Histochem J. 1975 Mar;7(2):179–186. doi: 10.1007/BF01004561. [DOI] [PubMed] [Google Scholar]
  17. Polak J. M., Bloom S. R., Adrian T. E., Heitz P., Bryant M. G., Pearse A. G. Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas. Lancet. 1976 Feb 14;1(7955):328–330. doi: 10.1016/s0140-6736(76)90084-2. [DOI] [PubMed] [Google Scholar]
  18. Said S. I., Faloona G. R. Elevated plasma and tissue levels of vasoactive intestinal polypeptide in the watery-diarrhea syndrome due to pancreatic, bronchogenic and other tumors. N Engl J Med. 1975 Jul 24;293(4):155–160. doi: 10.1056/NEJM197507242930401. [DOI] [PubMed] [Google Scholar]
  19. Sanzenbacher L. J., Mekhjian H. S., King D. R., Zollinger R. M. Studies on the potential role of secretin in the islet cell tumor diarrheogenic syndrome. Ann Surg. 1972 Sep;176(3):394–402. doi: 10.1097/00000658-197209000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Schwartz T. W., Rehfeld J. F., Stadil F., Larson L. I., Chance R. E., Moon N. Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet. 1976 May 22;1(7969):1102–1105. doi: 10.1016/s0140-6736(76)90065-9. [DOI] [PubMed] [Google Scholar]
  21. Tomita T. Pathology of ulcerogenic and diarrheogenic tumors of the pancreas. Acta Pathol Jpn. 1974 Mar;24(2):189–205. doi: 10.1111/j.1440-1827.1974.tb00817.x. [DOI] [PubMed] [Google Scholar]
  22. Verner J. V., Morrison A. B. Endocrine pancreatic islet disease with diarrhea. Report of a case due to diffuse hyperplasia of nonbeta islet tissue with a review of 54 additional cases. Arch Intern Med. 1974 Mar;133(3):492–499. doi: 10.1001/archinte.133.3.492. [DOI] [PubMed] [Google Scholar]
  23. Zollinger R. M. Islet cell tumors of the pancreas and the alimentary tract. Am J Surg. 1975 Feb;129(2):102–110. doi: 10.1016/0002-9610(75)90284-6. [DOI] [PubMed] [Google Scholar]