DepMap: The Cancer Dependency Map Project at Broad Institute

Aviad Tsherniak, Francisca Vazquez, Phillip G. Montgomery, Barbara A. Weir, ... Gregory Kryukov, Glenn S. Cowley, Stanley Gill, William F. Harrington, Sasha Pantel, John M. Krill-Burger, Robin M. Meyers, Levi Ali, Amy Goodale, Yenarae Lee, Guozhi Jiang, Jessica Hsiao, William F. J. Gerath, Sara Howell, Erin Merkel, Mahmoud Ghandi, Levi A. Garraway, David E. Root, Todd R. Golub, Jesse S. Boehm, & William C. Hahn. Defining a Cancer Dependency Map. Cell July 27, 2017. DOI: j.cell.2017.06.010

Andrew J. Aguirre, Robin M. Meyers, Barbara A. Weir, Francisca Vazquez, ... Cheng-Zhong Zhang, Uri Ben-David, April Cook, Gavin Ha, William F. Harrington, Mihir B. Doshi, Maria Kost-Alimova, Stanley Gill, Han Xu, Levi D. Ali, Guozhi Jiang, Sasha Pantel, Yenarae Lee, Amy Goodale, Andrew D. Cherniack, Coyin Oh, Gregory Kryukov, Glenn S. Cowley, Levi A. Garraway, Kimberly Stegmaier, Charles W. Roberts, Todd R. Golub, Matthew Meyerson, David E. Root, Aviad Tsherniak, & William C. Hahn. Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. Cancer Discovery 6, 914-929. June 3, 2016.

Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, ... Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick H. Lizotte, Guozhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hubo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott A. Armstrong, Ken C. Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd R. Golub, David E. Root, & William C. Hahn. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Nature Scientific Data 1, Article number: 140035. September 30, 2014.

Mehmet Gönen, Barbara A. Weir, Glenn S. Cowley, Francisca Vazquez, ... Yuanfang Guan, Alok Jaiswal, Masayuki Karasuyama, Vladislav Uzunangelov, Tao Wang, Aviad Tsherniak, Sara Howell, Daniel Marbach, Bruce Hoff, Thea C. Norman, Antti Airola, Adrian Bivol, Kerstin Bunte, Daniel Carlin,2 Sahil Chopra, Alden Deran, Kyle Ellrott, Peddinti Gopalacharyulu, Kiley Graim, Samuel Kaski, Suleiman A. Khan, Yulia Newton, Sam Ng, Tapio Pahikkala, Evan Paull, Artem Sokolov, Hao Tang,1 Jing Tang, Krister Wennerberg, Yang Xie, Xiaowei Zhan, Fan Zhu, Broad-DREAM Community, Tero Aittokallio, Hiroshi Mamitsuka, Joshua M. Stuart, Jesse S. Boehm, David E. Root, Guanghua Xiao, Gustavo Stolovitzky, William C. Hahn, & Adam A. Margolin. A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines. Cell Syst. 2017 Nov 22;5(5):485-497.e3. doi: 10.1016/j.cels.2017.09.004. Epub 2017 Oct 4.

Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao, ... Joshua D. Campbell, Aruna Ramachandran, Yoichiro Mitsuishi, Gavin Ha, Juliann Shih, Francisca Vazquez, Aviad Tsherniak, Alison M. Taylor, Jin Zhou, Zhong Wu, Ashton C. Berger, Marios Giannakis, William C. Hahn, Andrew D. Cherniack, & Matthew Meyerson. Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discov September 29 2017 DOI: 10.1158/2159-8290.CD-17-0532

Brenton R. Paolella, William J. Gibson, Laura M. Urbanski, John A. Alberta, ... Travis I. Zack, Pratiti Bandopadhayay, Caitlin A. Nichols, Pankaj K. Agarwalla, Meredith S. Brown, Rebecca Lamothe, Yong Yu, Peter S. Choi, Esther A. Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A. Weir, David E. Root, Glenn S. Cowley, Sara J. Buhrlage, Charles D. Stiles, Benjamin L. Ebert, William C. Hahn, Robin Reed, & Rameen Beroukhim. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife 2017 Feb 8;6. pii: e23268. doi: 10.7554/eLife.23268.

Jong Wook Kim, Olga B. Botvinnik, Omar Abudayyeh, Chet Birger, ... Joseph Rosenbluh, Yashaswi Shrestha, Mohamed E. Abazeed, Peter S. Hammerman, Daniel DiCara, David J. Konieczkowski, Cory M. Johannessen, Arthur Liberzon, Amir Reza Alizad-Rahvar, Gabriela Alexe, Andrew Aguirre, Mahmoud Ghandi, Heidi Greulich, Francisca Vazquez, Barbara A. Weir, Eliezer M. Van Allen, Aviad Tsherniak, Diane D. Shao, Travis I. Zack, Michael Noble, Gad Getz, Rameen Beroukhim, Levi A. Garraway, Masoud Ardakani, Chiara Romualdi, Gabriele Sales, David A. Barbie, Jesse S. Boehm, William C. Hahn, Jill P. Mesirov, & Pablo Tamayo. Characterizing genomic alterations in cancer by complementary functional associations. Nature Biotechnology 2016 May;34(5):539-46. doi: 10.1038/nbt.3527. Epub 2016 Apr 18.

Gregory V. Kryukov, Frederick H. Wilson, Jason R. Ruth, Joshiawa Paulk, ... Aviad Tsherniak, Sara E. Marlow, Francisca Vazquez, Barbara A. Weir, Mark E. Fitzgerald, Minoru Tanaka, Craig M. Bielski, Justin M. Scott, Courtney Dennis, Glenn S. Cowley, Jesse S. Boehm, David E. Root, Todd R. Golub, Clary B. Clish, James E. Bradner, William C. Hahn, & Levi A. Garraway. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science 2016 Mar 11;351(6278):1214-8. doi: 10.1126/science.aad5214. Epub 2016 Feb 11.

Kimberly H. Kim, Woojin Kim, Thomas P. Howard, Francisca Vazquez, ... Aviad Tsherniak, Jennifer N. Wu, Weishan Wang, Jeffrey R. Haswell, Loren D. Walensky, William C. Hahn, Stuart H. Orkin, & Charles W. M. Roberts.SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine 2015 Dec;21(12):1491-6. doi: 10.1038/nm.3968. Epub 2015 Nov 9.

Mark M. Pomerantz, Fugen Li, David Y. Takeda, Romina Lenci, ... Apurva Chonkar, Matthew Chabot, Paloma Cejas, Francisca Vazquez, Jennifer Cook, Ramesh A. Shivdasani, Michaela Bowden, Rosina Lis, William C Hahn, Philip W. Kantoff, Myles Brown, Massimo Loda, Henry W. Long, & Matthew L. Freedman. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nature Genetics 2015 Nov;47(11):1346-51. doi: 10.1038/ng.3419. Epub 2015 Oct 12. PMCID: PMC4707683.