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Elastina – Wikipédia, a enciclopédia livre

Origem: Wikipédia, a enciclopédia livre.

Elastina

Identificadores

ELN; SVAS; WBS; WS

IDs externos

OMIM: 130160 MGI: 95317 HomoloGene: 73880 GeneCards: ELN Gene

Ontologia do gene
Função molecular	•extracellular matrix structural constituent •protein binding •extracellular matrix constituent conferring elasticity •extracellular matrix binding
Componente celular	•proteinaceous extracellular matrix •mitochondrion
Processo biológico	•blood vessel remodeling •skeletal muscle tissue development •respiratory gaseous exchange •blood circulation •cell proliferation •organ morphogenesis •extracellular matrix organization •regulation of actin filament polymerization •stress fiber assembly
Sources: Amigo / QuickGO

Ortólogos

Espécies

Humano

Rato

RefSeq (mRNA)

RefSeq (proteína)

Localização (UCSC)

Chr 7:
73.44 – 73.48 Mb

Chr 5:
134.7 – 134.75 Mb

Busca PubMed

[1]

[2]

A elastina é uma proteína de função estrutural que forma fibras elásticas. Costumam ocorrer em lugares como o pavilhão auditivo, o conduto auditivo externo, a trompa de Eustáquio, a epiglote, a cartilagem cuneiforme da laringe e nas artérias elásticas. Normalmente, têm uma coloração amarelada. A elastina se caracteriza por formar fibras mais finas que aquelas formadas pelo colágeno. Essas fibras cedem bastante à tração, mas retornam à forma original quando é cessada a força. Essa propriedade é responsável pela manutenção da pressão sangüínea nos períodos de diástole do ventrículo esquerdo, ou seja, quando o sangue não está saindo do coração. A Elastina confere a estas fibras elasticidade e resistência.

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Bax DV, Rodgers UR, Bilek MM, Weiss AS (2009). «Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3». J. Biol. Chem. 284 (42): 28616–23. PMC 2781405. PMID 19617625. doi:10.1074/jbc.M109.017525
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MeSH Elastin
Imagem de Histologia: 21402loa – Histology Learning System at Boston University
GeneReviews/NIH/NCBI/UW entry on Williams or Williams-Beuren Syndrome
The Elastin Protein
Microfibril