MR measurement of regional relative cerebral blood volume in epilepsy - PubMed

Clinical Trial

MR measurement of regional relative cerebral blood volume in epilepsy

R H Wu et al. J Magn Reson Imaging. 1999 Mar.

Abstract

The purpose of this study was to evaluate the utility of magnetic resonance (MR) relative cerebral blood volume (rCBV) maps for studying regional hemodynamic changes in interictal and ictal epilepsy patients. Ten epilepsy patients were examined on a 1.5 T MR system. Nine patients were investigated interictally and one patient ictally. In the nine interictal patients, the dynamic plane was defined coronally through the hippocampus symmetrically. For the ictal patient, an axial dynamic plane was defined and the patient was scanned during seizure. Positron emission tomography (PET) studies were performed in 8 of the 10 patients. Lower rCBV of the left hippocampus was predicted by rCBV maps in seven of the nine interictal patients. The mean ratios of rCBV were 1.96 for left hippocampus/white matter and 2.49 for right hippocampus/white matter. The difference between these two ratios is statistically significant (P = 0.01, t-test). In two of the nine interictal temporal lobe epilepsy patients, lower rCBV areas were observed in the right hippocampus. In the ictal patient, the regional rCBV map demonstrated increased blood volume in the lesions. In eight of eight patients who underwent PET studies, MR rCBV findings were consistent with PET findings. The results show that regional hemodynamic changes in epilepsy can be evaluated with dynamic contrast-enhanced MR imaging. MR rCBV maps are sensitive to characterize seizure foci both ictally and interictally.

Similar articles

• Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis.

  Nelissen N, Van Paesschen W, Baete K, Van Laere K, Palmini A, Van Billoen H, Dupont P. Nelissen N, et al. Neuroimage. 2006 Aug 15;32(2):684-95. doi: 10.1016/j.neuroimage.2006.04.185. Epub 2006 Jun 9. Neuroimage. 2006. PMID: 16762567

• Application of dynamic susceptibility contrast-enhanced perfusion in temporal lobe epilepsy.

  Xing W, Wang X, Xie F, Liao W. Xing W, et al. Acta Radiol. 2013 Feb 1;54(1):107-12. doi: 10.1258/ar.2012.110658. Epub 2012 Nov 1. Acta Radiol. 2013. PMID: 23117196

• Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT.

  Tae WS, Joo EY, Kim JH, Han SJ, Suh YL, Kim BT, Hong SC, Hong SB. Tae WS, et al. Neuroimage. 2005 Jan 1;24(1):101-10. doi: 10.1016/j.neuroimage.2004.08.005. Neuroimage. 2005. PMID: 15588601

• The relative contributions of MRI, SPECT, and PET imaging in epilepsy.

  Spencer SS. Spencer SS. Epilepsia. 1994;35 Suppl 6:S72-89. doi: 10.1111/j.1528-1157.1994.tb05990.x. Epilepsia. 1994. PMID: 8206016 Review.

• Clinical applications of magnetic resonance spectroscopy.

  Laxer KD. Laxer KD. Epilepsia. 1997;38 Suppl 4:S13-7. doi: 10.1111/j.1528-1157.1997.tb04534.x. Epilepsia. 1997. PMID: 9240236 Review.

Cited by

• Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review.

  Foss KD, Billhymer AC. Foss KD, et al. Front Vet Sci. 2024 Jul 3;11:1427403. doi: 10.3389/fvets.2024.1427403. eCollection 2024. Front Vet Sci. 2024. PMID: 39021411 Free PMC article. Review.

• The Utility of Arterial Transit Time Measurement for Evaluating the Hemodynamic Perfusion State of Patients with Chronic Cerebrovascular Stenosis or Occlusive Disease: Correlative Study between MR Imaging and ¹⁵O-labeled H₂O Positron Emission Tomography.

  Takeuchi K, Isozaki M, Higashino Y, Kosaka N, Kikuta KI, Ishida S, Kanamoto M, Takei N, Okazawa H, Kimura H. Takeuchi K, et al. Magn Reson Med Sci. 2023 Jul 1;22(3):289-300. doi: 10.2463/mrms.mp.2020-0123. Epub 2022 May 10. Magn Reson Med Sci. 2023. PMID: 35545508 Free PMC article.

• Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms.

  Chin J, Scharfman HE. Chin J, et al. Epilepsy Behav. 2013 Mar;26(3):343-51. doi: 10.1016/j.yebeh.2012.11.040. Epub 2013 Jan 13. Epilepsy Behav. 2013. PMID: 23321057 Free PMC article. Review.

• MRI perfusion analysis using freeware, standard imaging software.

  Hartmann A, Scholz VB, Lautenschläger IE. Hartmann A, et al. BMC Vet Res. 2020 May 18;16(1):141. doi: 10.1186/s12917-020-02352-0. BMC Vet Res. 2020. PMID: 32423403 Free PMC article.

• Neurotoxic saboteurs: straws that break the hippo's (hippocampus) back drive cognitive impairment and Alzheimer's Disease.

  Daulatzai MA. Daulatzai MA. Neurotox Res. 2013 Oct;24(3):407-59. doi: 10.1007/s12640-013-9407-2. Epub 2013 Jul 3. Neurotox Res. 2013. PMID: 23820984 Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Wiley

• Medical

  • MedlinePlus Health Information