Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936 - PubMed

Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936

P E Sum et al. Bioorg Med Chem Lett. 1999.

Abstract

A number of new glycylcyclines were synthesized for structure-activity relationship study. Many of the derivatives exhibit potent, broad spectrum antibacterial activity against both tetracycline susceptible and resistant organisms. GAR-936 (TBG-MINO) shows better activity than the previously reported DMG-MINO and DMG-DMDOT.

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