Y-chromosome and mitochondrial DNA polymorphisms in Indian populations - PubMed

Y-chromosome and mitochondrial DNA polymorphisms in Indian populations

K Thangaraj et al. Electrophoresis. 1999 Jun.

Abstract

Y-chromosome polymorphism using short tandem repeat (STR) markers on 94 normal males belonging to the Brahmin and Kamma caste populations of Andhra Pradesh, India, and Siddis, a migrant population from Africa, inhabiting Hyderabad, India, revealed heterogeneity as indicated by network analysis. We have observed population-specific haplotypes and alleles. Analysis of Y-Alu polymorphism (YAP) in Siddis showed the presence of Alu insertion in 40% of the individuals. However, YAP insertion was not found in Brahmins and Kammas. The dendrogram based on hypervariable region I (HVR I) of the displacement loop (D-loop) sequence of mitochondrial DNA (mtDNA) of Siddis showed genetic relationships to African populations. YAP and mtDNA analysis of Siddis also confirmed their immigration from Africa.

Similar articles

• Y-chromosome SNP haplotypes suggest evidence of gene flow among caste, tribe, and the migrant Siddi populations of Andhra Pradesh, South India.

  Ramana GV, Su B, Jin L, Singh L, Wang N, Underhill P, Chakraborty R. Ramana GV, et al. Eur J Hum Genet. 2001 Sep;9(9):695-700. doi: 10.1038/sj.ejhg.5200708. Eur J Hum Genet. 2001. PMID: 11571559

• mtDNA variation in caste populations of Andhra Pradesh, India.

  Bamshad M, Fraley AE, Crawford MH, Cann RL, Busi BR, Naidu JM, Jorde LB. Bamshad M, et al. Hum Biol. 1996 Feb;68(1):1-28. Hum Biol. 1996. PMID: 8907753

• Phylogeography of mitochondrial DNA and Y-chromosome haplogroups reveal asymmetric gene flow in populations of Eastern India.

  Sahoo S, Kashyap VK. Sahoo S, et al. Am J Phys Anthropol. 2006 Sep;131(1):84-97. doi: 10.1002/ajpa.20399. Am J Phys Anthropol. 2006. PMID: 16485297

• [Haplotypes of two diallelic Y chromosome loci in the indigenous and migrant populations of Siberia].

  Stepanov VA, Puzyrev VP. Stepanov VA, et al. Genetika. 2000 Jan;36(1):87-92. Genetika. 2000. PMID: 10732284 Russian.

• Fathers and sons: the Y chromosome and human evolution.

  Jobling MA, Tyler-Smith C. Jobling MA, et al. Trends Genet. 1995 Nov;11(11):449-56. doi: 10.1016/s0168-9525(00)89144-1. Trends Genet. 1995. PMID: 8578602 Review.

Cited by

• The maternal U1 haplogroup in the Koraga tribe as a correlate of their North Dravidian linguistic affinity.

  Sequeira JJ, Vinuthalakshmi K, Das R, van Driem G, Mustak MS. Sequeira JJ, et al. Front Genet. 2024 Feb 7;14:1303628. doi: 10.3389/fgene.2023.1303628. eCollection 2023. Front Genet. 2024. PMID: 38384360 Free PMC article.

• Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists.

  Sengupta S, Zhivotovsky LA, King R, Mehdi SQ, Edmonds CA, Chow CE, Lin AA, Mitra M, Sil SK, Ramesh A, Usha Rani MV, Thakur CM, Cavalli-Sforza LL, Majumder PP, Underhill PA. Sengupta S, et al. Am J Hum Genet. 2006 Feb;78(2):202-21. doi: 10.1086/499411. Epub 2005 Dec 16. Am J Hum Genet. 2006. PMID: 16400607 Free PMC article.

• Complex genetic origin of Indian populations and its implications.

  Tamang R, Singh L, Thangaraj K. Tamang R, et al. J Biosci. 2012 Nov;37(5):911-9. doi: 10.1007/s12038-012-9256-9. J Biosci. 2012. PMID: 23107926 Review.

• Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis?

  Thangaraj K, Reddy AG, Singh L. Thangaraj K, et al. Int J Legal Med. 2002 Apr;116(2):121-3. doi: 10.1007/s00414-001-0262-y. Int J Legal Med. 2002. PMID: 12056520

• Reconstructing Indian population history.

  Reich D, Thangaraj K, Patterson N, Price AL, Singh L. Reich D, et al. Nature. 2009 Sep 24;461(7263):489-94. doi: 10.1038/nature08365. Nature. 2009. PMID: 19779445 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley