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Activity of pleconaril against enteroviruses - PubMed

Activity of pleconaril against enteroviruses

D C Pevear et al. Antimicrob Agents Chemother. 1999 Sep.

Abstract

The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most commonly isolated enterovirus serotypes was examined. The latter viruses were isolated by the Centers for Disease Control and Prevention during the 1970s and 1980s from clinically ill subjects. Pleconaril at a concentration of </=0.03 microM inhibited the replication of 50% of all clinical isolates tested. Ninety percent of the isolates were inhibited at a drug concentration of </=0.18 microM. The most sensitive serotype, echovirus serotype 11, was also the most prevalent enterovirus in the United States from 1970 to 1983. Pleconaril was further tested for oral activity in three animal models of lethal enterovirus infection: coxsackievirus serotype A9 infection in suckling mice, coxsackievirus serotype A21 strain Kenny infection in weanling mice, and coxsackievirus serotype B3 strain M infection in adult mice. Treatment with pleconaril increased the survival rate in all three models for both prophylactic and therapeutic dosing regimens. Moreover, pleconaril dramatically reduced virus levels in target tissues of coxsackievirus serotype B3 strain M-infected animals. Pleconaril represents a promising new drug candidate for potential use in the treatment of human enteroviral infections.

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Figures

FIG. 1
FIG. 1

Structure of pleconaril.

FIG. 2
FIG. 2

Activity of pleconaril in mouse models of enterovirus infection. (A) CVA9 in suckling mice; (B) CVA21 strain Kenny in weanling mice; (C) CVB3 strain M in adult mice.

FIG. 3
FIG. 3

CVB3 strain M titers in pancreases (A) and hearts (B) of placebo- or pleconaril-treated adult mice.

FIG. 4
FIG. 4

Serum pleconaril levels in adult mice after single oral dosing.

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