Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 - PubMed

Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

D Yang et al. Science. 1999.

Abstract

Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.

Comment in

• Defensins and host defense.

  Ganz T. Ganz T. Science. 1999 Oct 15;286(5439):420-1. doi: 10.1126/science.286.5439.420. Science. 1999. PMID: 10577203 No abstract available.

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