Modes of regulation of ubiquitin-mediated protein degradation - PubMed

Review

Modes of regulation of ubiquitin-mediated protein degradation

D Kornitzer et al. J Cell Physiol. 2000 Jan.

Abstract

The ubiquitin-proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin-mediated degradation is involved in physiological regulation of many cellular processes, including cell cycle progression, differentiation, and signal transduction. Here, we review the basic mechanisms of the ubiquitin system and the various ways in which ubiquitin-mediated degradation can be modulated by physiological signals.

Similar articles

• The ubiquitin system.

  Hershko A, Ciechanover A. Hershko A, et al. Annu Rev Biochem. 1998;67:425-79. doi: 10.1146/annurev.biochem.67.1.425. Annu Rev Biochem. 1998. PMID: 9759494 Review.

• The ubiquitin-proteasome pathway: on protein death and cell life.

  Ciechanover A. Ciechanover A. EMBO J. 1998 Dec 15;17(24):7151-60. doi: 10.1093/emboj/17.24.7151. EMBO J. 1998. PMID: 9857172 Free PMC article. Review. No abstract available.

• Ubiquitin-mediated protein modification and degradation.

  Schwartz AL, Ciechanover A. Schwartz AL, et al. Am J Respir Cell Mol Biol. 1992 Nov;7(5):463-8. doi: 10.1165/ajrcmb/7.5.463. Am J Respir Cell Mol Biol. 1992. PMID: 1329865 Review.

• Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.

  Wilkinson KD. Wilkinson KD. Semin Cell Dev Biol. 2000 Jun;11(3):141-8. doi: 10.1006/scdb.2000.0164. Semin Cell Dev Biol. 2000. PMID: 10906270 Review.

• Kip1 degradation via the ubiquitin-proteasome pathway.

  Tam SW, Theodoras AM, Pagano M. Tam SW, et al. Leukemia. 1997 Apr;11 Suppl 3:363-6. Leukemia. 1997. PMID: 9209391

Cited by

• PFKFB3: A Potential Key to Ocular Angiogenesis.

  Zhou ZY, Wang L, Wang YS, Dou GR. Zhou ZY, et al. Front Cell Dev Biol. 2021 Mar 11;9:628317. doi: 10.3389/fcell.2021.628317. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33777937 Free PMC article. Review.

• Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.

  Jung HY, Wang X, Jun S, Park JI. Jung HY, et al. J Biol Chem. 2013 Mar 8;288(10):7252-62. doi: 10.1074/jbc.M112.416792. Epub 2013 Jan 28. J Biol Chem. 2013. PMID: 23362280 Free PMC article.

• Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

  Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM. Zhang Y, et al. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13354-9. doi: 10.1073/pnas.240347797. Proc Natl Acad Sci U S A. 2000. PMID: 11078524 Free PMC article.

• Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2.

  de Hoog CL, Koehler JA, Goldstein MD, Taylor P, Figeys D, Moran MF. de Hoog CL, et al. Mol Cell Biol. 2001 Mar;21(6):2107-17. doi: 10.1128/MCB.21.6.2107-2117.2001. Mol Cell Biol. 2001. PMID: 11238945 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database