Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation - PubMed

Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation

C R Pugh et al. Behav Brain Res. 1999 Dec.

Abstract

Isolating rats immediately after conditioning impairs contextual but not auditory-cue fear conditioning. The reported experiments examine the involvement of brain interleukin-1beta (IL-1beta) in the impairment in contextual fear conditioning caused by social isolation. As measured by the conditioned freezing response, 5 h of social isolation after conditioning, impaired contextual but not auditory-cue fear conditioning in adult male Sprague-Dawley rats. Social isolation for 1 or 3 h after conditioning also increased IL-1beta protein in the hippocampus and cerebral cortex. No differences in IL-1beta protein levels were found in the pituitary or the hypothalamus. Intracerebroventricular (ICV) IL-1 receptor antagonist (IL-1ra) given after conditioning prevented the impairment in contextual fear conditioning caused by isolation. ICV IL-1ra had no effect on auditory-cue fear conditioning in these same animals, nor did it affect the level of contextual fear conditioning displayed by home cage controls. Like isolation, ICV IL-1beta (10 or 20 ng) after conditioning also impaired contextual but not auditory-cue fear conditioning. These results suggest that increased levels of brain IL-1beta play a role in producing the impairment in contextual fear conditioning produced by social isolation. These findings also add to the generality of the idea that stressors induce IL-1beta activity in the brain and that IL-1beta may play physiological roles in the uninjured brain.

Similar articles

• Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.

  Pugh CR, Johnson JD, Martin D, Rudy JW, Maier SF, Watkins LR. Pugh CR, et al. Brain Res. 2000 Apr 7;861(1):8-15. doi: 10.1016/s0006-8993(99)02445-2. Brain Res. 2000. PMID: 10751560

• Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.

  Pugh CR, Kumagawa K, Fleshner M, Watkins LR, Maier SF, Rudy JW. Pugh CR, et al. Brain Behav Immun. 1998 Sep;12(3):212-29. doi: 10.1006/brbi.1998.0524. Brain Behav Immun. 1998. PMID: 9769157

• Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.

  Barrientos RM, Higgins EA, Sprunger DB, Watkins LR, Rudy JW, Maier SF. Barrientos RM, et al. Behav Brain Res. 2002 Aug 21;134(1-2):291-8. doi: 10.1016/s0166-4328(02)00043-8. Behav Brain Res. 2002. PMID: 12191816

• Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.

  Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF. Barrientos RM, et al. Neuroscience. 2003;121(4):847-53. doi: 10.1016/s0306-4522(03)00564-5. Neuroscience. 2003. PMID: 14580934

• The neuroanatomical and neurochemical basis of conditioned fear.

  Fendt M, Fanselow MS. Fendt M, et al. Neurosci Biobehav Rev. 1999 May;23(5):743-60. doi: 10.1016/s0149-7634(99)00016-0. Neurosci Biobehav Rev. 1999. PMID: 10392663 Review.

Cited by

• Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System.

  Hrelia P, Sita G, Ziche M, Ristori E, Marino A, Cordaro M, Molteni R, Spero V, Malaguti M, Morroni F, Hrelia S. Hrelia P, et al. Oxid Med Cell Longev. 2020 Aug 1;2020:8363245. doi: 10.1155/2020/8363245. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32832006 Free PMC article. Review.

• The immune system and developmental programming of brain and behavior.

  Bilbo SD, Schwarz JM. Bilbo SD, et al. Front Neuroendocrinol. 2012 Aug;33(3):267-86. doi: 10.1016/j.yfrne.2012.08.006. Epub 2012 Sep 9. Front Neuroendocrinol. 2012. PMID: 22982535 Free PMC article. Review.

• Neuroinflammation in the normal aging hippocampus.

  Barrientos RM, Kitt MM, Watkins LR, Maier SF. Barrientos RM, et al. Neuroscience. 2015 Nov 19;309:84-99. doi: 10.1016/j.neuroscience.2015.03.007. Epub 2015 Mar 12. Neuroscience. 2015. PMID: 25772789 Free PMC article. Review.

• Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition.

  Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. Bilbo SD, et al. J Neurosci. 2005 Aug 31;25(35):8000-9. doi: 10.1523/JNEUROSCI.1748-05.2005. J Neurosci. 2005. PMID: 16135757 Free PMC article.

• Conjunctive representations, the hippocampus, and contextual fear conditioning.

  Rudy JW, O'Reilly RC. Rudy JW, et al. Cogn Affect Behav Neurosci. 2001 Mar;1(1):66-82. doi: 10.3758/cabn.1.1.66. Cogn Affect Behav Neurosci. 2001. PMID: 12467104

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program