Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends - PubMed
. 1999 Dec;42(12):1395-403.
doi: 10.1007/s001250051309.
Affiliations
- PMID: 10651256
- DOI: 10.1007/s001250051309
Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends
P Onkamo et al. Diabetologia. 1999 Dec.
Erratum in
- Diabetologia 2000 May;43(5):685
Abstract
Aims/hypothesis: Several reports on the incidence of Type I (insulin-dependent) diabetes mellitus have suggested that the incidence is increasing. The aim of this study was to find out whether the incidence is increasing globally or restricted to a selected populations only and to estimate the magnitude of the change in incidence.
Methods: During 1960 to 1996 37 studies in 27 countries were carried out. To fulfil the inclusion criteria the study periods ranged from 8-32 years. The temporal trend was fitted by linear regression, with the logarithm of the age-standardized incidence as the dependent variable and the calendar year as the independent variable. Then, the regression coefficient (x 100%) is approximately the average relative increase in incidence per year (as percentage).
Results: Results from the pooled data from all 37 populations showed that the overall increase in incidence was 3.0% per year (95% CI 2.6; 3.3, p = 0.0001). The statistically significant increase was found in 24 of 37 populations including all high incidence (> 14.6 per 100000 a year) populations. The relative increase was, however, steeper in the populations with a lower incidence. The correlation between logarithm of the incidence and the increase in incidence was r = -0.56, p = 0.0004.
Conclusion/interpretation: The incidence of Type I diabetes is increasing worldwide both in low and high incidence populations. By the year 2010 the incidence will be 50 per 100000 a year in Finland and also in many other populations it will exceed 30 per 100000 a year.
Comment in
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Bruno G, Biggeri A, Merletti F, Pagano G. Bruno G, et al. Diabetologia. 2000 Oct;43(10):1334-6. doi: 10.1007/s001250051534. Diabetologia. 2000. PMID: 11079757 No abstract available.
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Descriptive epidemiology of type 1 diabetes--is it still in?
Knip M. Knip M. Diabetologia. 2012 May;55(5):1227-30. doi: 10.1007/s00125-012-2522-4. Epub 2012 Mar 9. Diabetologia. 2012. PMID: 22402989
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