Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice - PubMed

Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice

A Asakawa et al. Peptides. 1999 Dec.

Abstract

This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued for 4 h. The intraperitoneal (i.p.) injection of mPP (0.03-30 nmol) dose-dependently decreased food intake. A significant decrease was observed 20 min after i.p. injection and continued for 4 h. In the elevated plus maze test, the i.c.v. injection of mPP (0.003-3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice.

Similar articles

• The effects of pancreatic polypeptide on locomotor activity and food intake in mice.

  Liu YL, Semjonous NM, Murphy KG, Ghatei MA, Bloom SR. Liu YL, et al. Int J Obes (Lond). 2008 Nov;32(11):1712-5. doi: 10.1038/ijo.2008.160. Epub 2008 Sep 9. Int J Obes (Lond). 2008. PMID: 18779824

• Endomorphins have orexigenic and anxiolytic activities in mice.

  Asakawa A, Inui A, Momose K, Ueno N, Fujino MA, Kasuga M. Asakawa A, et al. Neuroreport. 1998 Jul 13;9(10):2265-7. doi: 10.1097/00001756-199807130-00022. Neuroreport. 1998. PMID: 9694212

• Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice.

  Asakawa A, Inui A, Yuzuriha H, Nagata T, Kaga T, Ueno N, Fujino MA, Kasuga M. Asakawa A, et al. Horm Metab Res. 2001 Sep;33(9):554-8. doi: 10.1055/s-2001-17205. Horm Metab Res. 2001. PMID: 11561216

• Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth.

  Dembiński A, Warzecha Z, Ceranowicz P, Pawlik M, Dembiński M, Kabat K, Konturek SJ, Kownacki P, Hładki W, Pawlik WW. Dembiński A, et al. J Physiol Pharmacol. 2004 Mar;55(1 Pt 2):223-37. J Physiol Pharmacol. 2004. PMID: 15082880

• Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats.

  Clark JT, Kalra PS, Kalra SP. Clark JT, et al. Endocrinology. 1985 Dec;117(6):2435-42. doi: 10.1210/endo-117-6-2435. Endocrinology. 1985. PMID: 3840737

Cited by

• Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY.

  Schonhoff S, Baggio L, Ratineau C, Ray SK, Lindner J, Magnuson MA, Drucker DJ, Leiter AB. Schonhoff S, et al. Mol Cell Biol. 2005 May;25(10):4189-99. doi: 10.1128/MCB.25.10.4189-4199.2005. Mol Cell Biol. 2005. PMID: 15870288 Free PMC article.

• Neuropeptide Y receptors: a promising target for cancer imaging and therapy.

  Li J, Tian Y, Wu A. Li J, et al. Regen Biomater. 2015 Sep;2(3):215-9. doi: 10.1093/rb/rbv013. Epub 2015 Aug 7. Regen Biomater. 2015. PMID: 26816643 Free PMC article.

• Neuropeptide Y in Alcohol Addiction and Affective Disorders.

  Thorsell A, Mathé AA. Thorsell A, et al. Front Endocrinol (Lausanne). 2017 Jul 31;8:178. doi: 10.3389/fendo.2017.00178. eCollection 2017. Front Endocrinol (Lausanne). 2017. PMID: 28824541 Free PMC article. Review.

• Obesity treatment: novel peripheral targets.

  Field BC, Chaudhri OB, Bloom SR. Field BC, et al. Br J Clin Pharmacol. 2009 Dec;68(6):830-43. doi: 10.1111/j.1365-2125.2009.03522.x. Br J Clin Pharmacol. 2009. PMID: 20002077 Free PMC article. Review.

• Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y.

  Comeras LB, Herzog H, Tasan RO. Comeras LB, et al. Ann N Y Acad Sci. 2019 Nov;1455(1):59-80. doi: 10.1111/nyas.14179. Epub 2019 Jul 4. Ann N Y Acad Sci. 2019. PMID: 31271235 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information

• Molecular Biology Databases

  • Guide to Pharmacology