Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview - PubMed

Review

Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview

L Büdinger et al. Allergy. 2000 Feb.

Abstract

Metal ions such as Ni2+, Co2+, Cu2+, or Cr3+ are haptens with a high immunogenic potential, as contact dermatitis caused by ionic metals occurs in about 10-15% of the human population. Since alloys containing Ni2+, Co2+, and Cr3+ are components of implants in replacement surgery, dentures, orthodontic wires, and various other devices, adverse reactions to metal ions create serious problems in practical medicine as incompatibility reactions to metal-containing biomaterials. On the other hand, contact dermatitis to metal ions such as Ni2+ is a well-established model for studying the molecular mechanisms involved in the recognition of haptens by the immune system. Although many investigations have been performed to elucidate the molecular interactions causing contact hypersensitivity in man, many aspects remain to be clarified. This review will focus on the experimental data accumulated so far on the immunologic mechanisms responsible for the recognition of metal ions by T cells and eliciting adverse immune reactions causing contact dermatitis.

Similar articles

• The molecular basis of metal recognition by T cells.

  Sinigaglia F. Sinigaglia F. J Invest Dermatol. 1994 Apr;102(4):398-401. doi: 10.1111/1523-1747.ep12372149. J Invest Dermatol. 1994. PMID: 8151118 Review.

• Interactions of chemicals and metal ions with proteins and role for immune responses.

  Martin SF, Merfort I, Thierse HJ. Martin SF, et al. Mini Rev Med Chem. 2006 Mar;6(3):247-55. doi: 10.2174/138955706776073493. Mini Rev Med Chem. 2006. PMID: 16515463 Review.

• T lymphocyte-mediated immune responses to chemical haptens and metal ions: implications for allergic and autoimmune disease.

  Martin SF. Martin SF. Int Arch Allergy Immunol. 2004 Jul;134(3):186-98. doi: 10.1159/000078765. Epub 2004 Jun 1. Int Arch Allergy Immunol. 2004. PMID: 15178887 Review.

• Lack of antagonism to Ni2+ and Co2+ contact allergy from other essential divalent metal ions.

  van den Broeke LT, Nilsson JL, Scheynius A, Wahlberg JE, Karlberg AT. van den Broeke LT, et al. Contact Dermatitis. 1998 May;38(5):266-73. doi: 10.1111/j.1600-0536.1998.tb05741.x. Contact Dermatitis. 1998. PMID: 9667444

• Multiple sensitivities to transition metals: the nickel palladium reactions.

  Santucci B, Cannistraci C, Cristaudo A, Picardo M. Santucci B, et al. Contact Dermatitis. 1996 Nov;35(5):283-6. doi: 10.1111/j.1600-0536.1996.tb02389.x. Contact Dermatitis. 1996. PMID: 9007373

Cited by

• Effects of phosphate-based glasses on T lymphocytes in vitro.

  Kesisoglou A, Knowles JC, Olsen I. Kesisoglou A, et al. J Mater Sci Mater Med. 2002 Dec;13(12):1189-92. doi: 10.1023/a:1021110609168. J Mater Sci Mater Med. 2002. PMID: 15348664

• Mathematical modelling of contact dermatitis from nickel and chromium.

  Ward JP, Franks SJ, Tindall MJ, King JR, Curtis A, Evans GS. Ward JP, et al. J Math Biol. 2019 Jul;79(2):595-630. doi: 10.1007/s00285-019-01371-2. Epub 2019 Jun 13. J Math Biol. 2019. PMID: 31197444 Free PMC article.

• [Allergy diagnostics in implant intolerance].

  Thomas P, Thomsen M. Thomas P, et al. Orthopade. 2008 Feb;37(2):131-5. doi: 10.1007/s00132-008-1194-8. Orthopade. 2008. PMID: 18227997 German.

• IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis.

  Liu J, Harberts E, Tammaro A, Girardi N, Filler RB, Fishelevich R, Temann A, Licona-Limón P, Girardi M, Flavell RA, Gaspari AA. Liu J, et al. J Invest Dermatol. 2014 Jul;134(7):1903-1911. doi: 10.1038/jid.2014.61. Epub 2014 Jan 31. J Invest Dermatol. 2014. PMID: 24487305 Free PMC article.

• Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients.

  Bordignon V, Palamara F, Cordiali-Fei P, Vento A, Aiello A, Picardo M, Ensoli F, Cristaudo A. Bordignon V, et al. BMC Immunol. 2008 May 15;9:19. doi: 10.1186/1471-2172-9-19. BMC Immunol. 2008. PMID: 18482439 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database