TNF alpha and the TNF receptor superfamily: structure-function relationship(s) - PubMed

Review

TNF alpha and the TNF receptor superfamily: structure-function relationship(s)

H T Idriss et al. Microsc Res Tech. 2000.

Abstract

Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers. TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK. The defining trait of these receptors is an extra cellular domain comprised of two to six repeats of cysteine rich motifs. Additionally, a number of structurally related "decoy receptors" exist that act to sequester TNF molecules, thereby rescuing cells from apoptosis. The crystal structures of TNF alpha, TNF beta, the extracellular domain of TNFR-1 (denoted sTNFR-1), and the TNF beta sTNFR-1 complex have been defined by crystallography. This article will review the structure/function relationships of the TNF alpha and the TNF receptor superfamily. It will also discuss insights as to how structural features play a role in the pleiotropic effects of TNF alpha.

Similar articles

• BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.

  Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. Gordon NC, et al. Biochemistry. 2003 May 27;42(20):5977-83. doi: 10.1021/bi034017g. Biochemistry. 2003. PMID: 12755599

• Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant.

  Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y. Mukai Y, et al. J Mol Biol. 2009 Jan 30;385(4):1221-9. doi: 10.1016/j.jmb.2008.11.053. Epub 2008 Dec 6. J Mol Biol. 2009. PMID: 19084540

• Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex.

  Cha SS, Song YL, Oh BH. Cha SS, et al. Vitam Horm. 2004;67:1-17. doi: 10.1016/S0083-6729(04)67001-4. Vitam Horm. 2004. PMID: 15110168 Review.

• The TNF ligand superfamily and its relevance for human diseases.

  Gruss HJ, Dower SK. Gruss HJ, et al. Cytokines Mol Ther. 1995 Jun;1(2):75-105. Cytokines Mol Ther. 1995. PMID: 9384666 Review.

• Distinct molecular mechanism for initiating TRAF6 signalling.

  Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H. Ye H, et al. Nature. 2002 Jul 25;418(6896):443-7. doi: 10.1038/nature00888. Nature. 2002. PMID: 12140561

Cited by

• Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives.

  Archontogeorgis K, Nena E, Papanas N, Steiropoulos P. Archontogeorgis K, et al. Pulm Med. 2014;2014:930535. doi: 10.1155/2014/930535. Epub 2014 Nov 27. Pulm Med. 2014. PMID: 25538852 Free PMC article. Review.

• Effect and Mechanism of Cotrimoxazole Against Talaromyces marneffei in vitro.

  Chen J, Chen R, Wei W, Qin F, Chen X, He J, Zhang H, Wang G, Shi M, Qin T, Liao Y, Wu Y, Lu B, Tao X, Ye L, Liang H, Jiang J. Chen J, et al. Mycopathologia. 2022 Dec;187(5-6):579-593. doi: 10.1007/s11046-022-00673-2. Epub 2022 Nov 1. Mycopathologia. 2022. PMID: 36318375

• Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches.

  Medina-Leyte DJ, Zepeda-García O, Domínguez-Pérez M, González-Garrido A, Villarreal-Molina T, Jacobo-Albavera L. Medina-Leyte DJ, et al. Int J Mol Sci. 2021 Apr 8;22(8):3850. doi: 10.3390/ijms22083850. Int J Mol Sci. 2021. PMID: 33917744 Free PMC article. Review.

• Alterations in bone fracture healing associated with TNFRSF signaling pathways.

  Dong Y, Zhou H, Alhaskawi A, Wang Z, Lai J, Abdullah Ezzi SH, Kota VG, Abdulla Hasan Abdulla MH, Sun Z, Lu H. Dong Y, et al. Front Pharmacol. 2022 Oct 17;13:905535. doi: 10.3389/fphar.2022.905535. eCollection 2022. Front Pharmacol. 2022. PMID: 36324677 Free PMC article.

• Intranasal Immunization for Zika in a Pre-Clinical Model.

  Shah S, Patel P, Bagwe P, Kale A, Ferguson A, Adediran E, Arte T, Singh R, Uddin MN, D'Souza MJ. Shah S, et al. Viruses. 2024 May 28;16(6):865. doi: 10.3390/v16060865. Viruses. 2024. PMID: 38932158 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal