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Apoptosis. Mitochondria--the death signal integrators - PubMed

️Sat Jan 01 2000

Comment

Apoptosis. Mitochondria--the death signal integrators

C Brenner et al. Science. 2000.

Abstract

Many of the intricate pathways of apoptosis that instruct a cell to kill itself involve the convergence of key proteins on the membranes of mitochondria. Such proteins induce the permeabilization of mitochondrial membranes and the release of caspase enzymes and nuclease activators that set in motion the final stages of programmed cell death. Now, as Brenner and Kroemer discuss in their Perspective, a proapoptotic transcription factor called TR3 has been found to move from its normal location in the nucleus to the mitochondria and to promote release of cytochrome c, a key event in apoptosis (Li et al.)

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, Zhang X. Li H, et al. Science. 2000 Aug 18;289(5482):1159-64. doi: 10.1126/science.289.5482.1159. Science. 2000. PMID: 10947977

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Apoptosis. Mitochondria--the death signal integrators - PubMed