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The evolutionary fate and consequences of duplicate genes - PubMed

️Sat Jan 01 2000

Comment

The evolutionary fate and consequences of duplicate genes

M Lynch et al. Science. 2000.

Abstract

Gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how frequently they evolve new functions. Observations from the genomic databases for several eukaryotic species suggest that duplicate genes arise at a very high rate, on average 0.01 per gene per million years. Most duplicated genes experience a brief period of relaxed selection early in their history, with a moderate fraction of them evolving in an effectively neutral manner during this period. However, the vast majority of gene duplicates are silenced within a few million years, with the few survivors subsequently experiencing strong purifying selection. Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species.

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Comment in

Evolutionary biology. Twinned genes live life in the fast lane.
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Comment on

Gene duplication and evolution.
Long M, Thornton K. Long M, et al. Science. 2001 Aug 31;293(5535):1551. doi: 10.1126/science.293.5535.1551a. Science. 2001. PMID: 11533445 No abstract available.
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The evolutionary fate and consequences of duplicate genes - PubMed